Navigation Links
Colon cancer shuts down receptor that could shut it down
Date:4/13/2009

AUGUSTA, Ga. Though a high-fiber diet has long been considered good for you and beneficial in staving off colon cancer, Medical College of Georgia researchers have discovered a reason why: roughage activates a receptor with cancer-killing potential.

Researchers report in the April issue of Cancer Research that the GPR109A receptor is activated by butyrate, a metabolite produced by fiber-eating bacteria in the colon. The receptor puts a double-whammy on cancer by sending signals that trigger cell death, or apoptosis, and shutting down a protein that causes inflammation, a precursor to cancer.

"We know the receptor is silenced in cancer but it's not like the gene goes away," says Dr. Vadivel Ganapathy, corresponding author and chair of the Department of Biochemistry and Molecular Biology in the MCG School of Medicine.

Cancer shuts down the receptor by chemically modifying its gene through a process called DNA methylation. It's a typical MO for cancer to turn genes off to suit its purpose which is why DNA methylation inhibitors already are under study for a variety of cancers.

But cancer patients likely also need something to ensure the receptor gets activated by butyrate, such as eating more roughage or, more likely, getting mega doses of butyrate or a compound with similar properties, Dr. Ganapathy says.

One of those activators, niacin, a B-complex vitamin, led to his discovery of the relationship between butyrate and GPR109A. Research teams at GlaxoSmithKline and the University of Heidelberg, Germany in 2003 showed cloned GPR109A mediated the protective cardiovascular effect of niacin, but was activated only if niacin levels in the blood were 1,000 times normal levels. That got the German research team to search for alternative activators of the receptor, resulting in identification of beta-hydroxybutyrate as a natural receptor activator. The same study showed butyrate also could activate the receptor but
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
2. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
3. Gastroenterology sets standards for CT colonography
4. Experts Compare Colon Cancer Treatment Outcomes
5. Doctors Office Outreach Boosts Colon Cancer Screening
6. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
7. Molecular profiling can accurately predict survival in colon cancer patients
8. Study Links Coronary Disease, Colon Cancer
9. Fecal Blood Tests Effective at Spotting Colon Cancer
10. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
11. Study makes progress in zoning in on biomarkers for better colon cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Colon cancer shuts down receptor that could shut it down
(Date:4/28/2015)... April 28, 2015 Board certified ... have developed a new, online acne treatment system ... sufferers using their specialized acne mapping technology. This ... the state of California with internet access to ... travel to a physical office. The online acne ...
(Date:4/28/2015)... (PRWEB) April 28, 2015 PFC Fitness ... at Omni La Costa Resort and Spa partners with ... continued weight loss and overall health at home. Utilizing ... health coaches, PFC RevUp ensures the healthy habits and ... pressures of life kick in and  clients are left to their own ...
(Date:4/28/2015)... Texas (PRWEB) April 28, 2015 ... Centrifuges Industry is a professional and in-depth research ... definition, classification, application, industry overview, industry chain structure, ... This report covers the global (US, Europe, Japan, ... analysis covering macroeconomic environment & economic situation analysis. ...
(Date:4/28/2015)... Pittsburgh, PA (PRWEB) April 28, 2015 ... The decision-making process when a loved one dies can ... affiliation, the funeral arrangements and final tribute ... serving families in need, Beinhauer Family Funeral Homes ... of services offered to families by doubling its number ...
(Date:4/28/2015)... 28, 2015 Two leaders in patient ... to Becker's Hospital Review’s list of 50 Experts ... Pronovost, M.D., Ph.D. , director of the Armstrong ... vice president for patient safety and quality at Johns ... vice president of medical affairs and chief patient safety ...
Breaking Medicine News(10 mins):Health News:New Online Acne Treatment Service for California 2Health News:PFC Fitness Camp Launches Bullet-Proof Accountability Platform for Sustained Weight Loss At Home 2Health News:PFC Fitness Camp Launches Bullet-Proof Accountability Platform for Sustained Weight Loss At Home 3Health News:Centrifuges Market 2015 Global Research Report 2Health News:Centrifuges Market 2015 Global Research Report 3Health News:Beinhauer's Increasing Number of Celebrants to Meet Growing Demand for Personalized Funeral Ceremonies 2Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 2Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 3Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 4
... 21 Innerscope Research(TM), a revolutionary,biometric media research ... appointment of three executives who will strengthen the,company,s ... The three ... experience,include Geoffrey Gill as Chief Financial Officer and ...
... 2008) How can moss help us to treat ... us about evolution? Can genetic studies of snapdragon populations ... quail teach us about human aging, reproduction, and hereditary diseases? ... , To answer these and other questions in biology, scientists ...
... WASHINGTON, Nov. 21 New inventions in computerized ... cognitive disabilities lead fuller,lives, said Jeff Zimman, Chairman ... annual Technology Innovators Conference in Washington,DC, a meeting ... to,promote innovation to assist people with disabilities. , ...
... , , FRIDAY, Nov. 21 (HealthDay News) -- The season of ... new research suggests. , Babies born in autumn -- about four ... a 30 percent increased risk of asthma compared to babies born ... first December issue of the American Journal of Respiratory and ...
... patients with cardiovascular disease are not given adequate drug therapy. ... current edition of Deutsches rzteblatt International ( Dtsch ... present the German results of this prospective, one-year survey. , ... enrolled 5594 patients in all, of whom 89.2% suffered from ...
... Texas, Nov. 21 Huntsman,Corporation (NYSE: HUN ) ... one of four Americans chosen by the American Cancer Society ... Given annually, the,award is reserved for those who have made ... Noting that Mr. Huntsman and his wife ...
Cached Medicine News:Health News:Innerscope Research Strengthens Management Team With Three Executive Appointments 2Health News:A new world of research possibilities with 'Emerging Model Organisms' 2Health News:New Applications for Cognitive Training 2Health News:Autumn Babies More Prone to Asthma 2Health News:Autumn Babies More Prone to Asthma 3Health News:Jon M. Huntsman Receives American Cancer Society Medal of Honor 2
(Date:4/28/2015)... Fla. , April 28, 2015 /PRNewswire/ ... is pleased to announce a partnership with ... radio frequency identification (RFID) storage and transport ... and Terso to enhance capabilities and provide ... iTraycer is a comprehensive inventory management system ...
(Date:4/28/2015)... 28, 2015  Clinicians from the Veterans Affairs Medical ... demonstrate that Leaf Healthcare,s new, wireless patient monitoring system ... prevention turn protocols. Their presentation will take place at ... San Antonio, Texas , April 29-May 3. ... "Optimizing patient turning resources by using a novel wearable ...
(Date:4/28/2015)... April 28, 2015 Exagen Diagnostics, Inc., ... significant unmet need for the accurate diagnosis and ... announced today that its Avise SLE+ Connective Tissue ... orders since launch, and that adoption continues to ... identifying Connective Tissue Disease (CTD), including, but not ...
Breaking Medicine Technology:Medical Tracking Solutions, Inc., Partners with Terso Solutions, Inc. 2VA Presentation at Wound Symposium to Show New Wireless Patient Monitoring System Improves Pressure Ulcer Turn Compliance 2VA Presentation at Wound Symposium to Show New Wireless Patient Monitoring System Improves Pressure Ulcer Turn Compliance 3VA Presentation at Wound Symposium to Show New Wireless Patient Monitoring System Improves Pressure Ulcer Turn Compliance 4Exagen Sees Growing Adoption of Avise Diagnostic for Connective Tissue Disease with New Milestone 2
... Aug. 2 Cytokine PharmaSciences,Inc. (CPSI) today ... inhibitors showed oral efficacy in animal models. ... it is advancing one of these compounds,into ... or MIF, is linked to many,conditions, including ...
... ARBOR, Mich., Aug. 3 Far more of today,s,heart attack ... clogged heart arteries than even a,decade ago, a new study ... from this urgent treatment,-- which is known to save lives ... it at all, the study shows. And the chance ...
Cached Medicine Technology:Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors 2Many Heart Attack Patients Don't Get Best Emergency Treatment 2Many Heart Attack Patients Don't Get Best Emergency Treatment 3Many Heart Attack Patients Don't Get Best Emergency Treatment 4
Straight shafts with 1 x 2 teeth. Wide serrated handle with polished finish....
Ergotec Vetriretinal Instrument System. Extra fine angled tips (3 mm). 20 ga. shaft tapering to 23 ga., 10 mm from tip. Overall length from rear rotation knob to tip....
Ergotec Vetriretinal Instrument System. Ultra-fine 3.35 mm tips. Angled 55 degrees. 20 gauge shaft. 30 mm in length. Overall length from rear rotation knob to tip....
For use with the Landers Vitrectomy Lens set (MVS 1079A). Shafts angled 45 degrees with curved grooved blades for holding the Landers vitrectomy lenses. Polished finish....
Medicine Products: