Navigation Links
Colon cancer risk in US traced to common ancester
Date:1/1/2008

Salt Lake City A married couple who sailed from England to America around 1630 may be the ancestors of hundreds of people alive today who are at risk for a hereditary form of colon cancer.

Researchers from Huntsman Cancer Institute (HCI) at The University of Utah have discovered a founder mutationa mutation that has been traced from many individuals in the present-day population back to a common ancestorwhich may contribute to a significant percentage of colon cancer cases in the United States.

An article reporting the finding was published today in Clinical Gastroenterology and Hepatology.

The researchers studied two large families, one in Utah and one in New York, that both carry a specific genetic mutation responsible for increased risk of colorectal cancer. They discovered that the two families share common ancestorsa couple who came to America from England in the 1630s, about the time of the Pilgrims.

The fact that this mutation can be traced so far back in time suggests that it could be carried by many more families in the United States than is currently known, says Deborah Neklason, Ph.D., a University of Utah research assistant professor and leader of the study. In fact, this founder mutation might be related to many colon cancer cases in the United States.

The mutation causes a condition called attenuated familial adenomatous polyposis (AFAP). Without proper clinical care, people with the AFAP mutation have a greater than 2 in 3 risk of colon cancer by age 80, compared to about 1 in 24 for the general population. Yet the cancer can be prevented with proper screening and care.

Knowing one has the condition can be life-saving, Neklason says. Not only are affected individuals at greater risk then the general population as they grow older, but precancerous polyps are often found in mutation carriers in their late teens and colon cancer has been diagnosed in individuals in their 20s.

However, she explains, clinical recognition of AFAP can be difficult because colon cancer develops on average in a persons 50s and the majority of sporadic, or non-hereditary, colon cancers occur after the age of 50. About a third of people with AFAP also have just a few polypsagain similar to that for sporadic colon cancerand they may have a limited family history.

People need to talk with their family, learn their family cancer history, and share this information with their doctors. Doctors need to be aware of AFAP, recognize people at risk, and know the screening and treatment protocols that can prevent colon cancer from developing, Neklason says.

The Utah family in this study has more than 7,000 descendants spanning nine generations recorded in the Utah Population Database (UPDB), a shared resource for genetics research housed at HCI. Researchers use UPDB to identify and study families that have higher than normal incidence of cancer or other disease, to analyze patterns of genetic inheritance, and to identify specific genetic mutations.

Known individuals in this one family account for 0.15 percent of all colorectal cancers reported in Utah from 1966 to 1995. Based on that percentage, researchers expected to see eight cases of colon cancer from this family among the over 5,000 reported between 1996 and 2003.

But after previous research identified this family as affected by AFAP, aggressive education and clinical intervention resulted in only one mutation carrier in the family being diagnosed with colon cancer during those years.

Preventing seven cancers may not sound like much, says Neklason. But thats seven colon cancers that didnt devastate this family. And consider that $50,000 is a conservative estimate for the cost of colorectal cancer treatment. That amounts to at least $350,000, and that means a lot for any family.


'/>"/>

Contact: Christopher Nelson
801-581-5148
University of Utah Health Sciences
Source:Eurekalert

Related medicine news :

1. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
2. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
3. Gastroenterology sets standards for CT colonography
4. Experts Compare Colon Cancer Treatment Outcomes
5. Doctors Office Outreach Boosts Colon Cancer Screening
6. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
7. Molecular profiling can accurately predict survival in colon cancer patients
8. Study Links Coronary Disease, Colon Cancer
9. Fecal Blood Tests Effective at Spotting Colon Cancer
10. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
11. Study makes progress in zoning in on biomarkers for better colon cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... Kenall Manufacturing, a leader in sealed healthcare ... The MPCNGX is a multi-function, sealed, LED luminaire that meets the needs of everyone ... when it’s needed. , A 2’ x 4’ model features four modes: ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... a women growing up with a schizophrenic mother in a unique, personal perspective ... who specializes in treating trauma and addictive disorders at her private psychotherapy practice. ...
(Date:12/7/2016)... Valley, CA (PRWEB) , ... December 07, 2016 , ... ... be used in several ways to restore a more youthful appearance to the face. ... now offer Sculptra, along with a variety of other treatments, to rejuvenate and renew ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... When it came time to blow out ... Just 40 minutes later, the Pediatric Heart Transplant team at Joe DiMaggio Children’s ... the Weston teen the hospital’s 30th heart transplant recipient. , “He was playing at ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... planning services to families and business owners in the greater Dallas metropolitan area, ... the Dallas Fallen Officer Foundation. , Established in 2009 by active police professionals ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Dec. 7, 2016 Global Pulmonary ... drugs studies the current as well as future ... this report include companies and intermediaries engaged in ... and/or drug-device combinations as well as new entrants ... an elaborate executive summary along with a market ...
(Date:12/7/2016)... Diplomat Pharmacy, Inc. (NYSE: DPLO) has launched Diplomat Specialty ... IV Infusion Professional, BioRx, MedPro Rx, and XAS Infusion Suites. ... diplomat.is/specialty-infusion .  ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ... "As we continue to build on the work we have ...
(Date:12/7/2016)... ALTO, Calif. , Dec. 7, 2016  Varian ... an update to its previously announced plans to separate ... be executed via a tax-free distribution to Varian stockholders ... stand-alone public company that will hold the Imaging Components ... expected to be executed by the end of January ...
Breaking Medicine Technology: