Navigation Links
Colon cancer exhibits a corresponding epigenetic pattern in mice and humans
Date:2/7/2013

ds of genetic and epigenetic changes at this stage, which complicates the analysis.

The matter is different for the corresponding polyps in mice, which the researchers can investigate considerably earlier following their formation. For this reason, scientists of the Max Planck Institute for Molecular Genetics have now pursued the question of which epigenetic changes in intestinal tumours occur first with the help of a mouse model.

"With mice, we can investigate the first changes much more easily than with humans", says Markus Morkel, who led the study. The scientists analysed the epigenetic changes in a strain of mice with a defective copy of the APC gene. This gene serves as an intestinal tumour suppressor in mice as well as in humans. Accordingly, it has lost its functionality in a majority of patients with colon cancer.

The results displayed a clear picture:The researchers recognised a recurring pattern of more than 13,000 epigenetic changes in all of the mouse tumour samples. By contrast, they did not find this pattern in healthy intestine or in intestinal stem cells, which are the cells of origin of the tumour. Since the mice and hence the tumours were less than three months old, the changes must have already spread shortly after the first genetic mutation in the APC gene within the tumour cells. According to the scientists, the first mutation already leads to pathological activation of numerous enzymes controlling the epigenetic mechanisms.

Remarkably, the molecular biologists discovered large parts of the tumour-specific epigenetic pattern not only in the mouse, but also in human colon cancer tissue. "These initial epigenetic changes could therefore serve as markers and significantly simplify the early diagnosis of colon tumours in the future", hopes Markus Morkel. Patients would merely have to provide a blood sample for the diagnosis and could forego an enteroscopic procedure.


'/>"/>

Contact: Markus Morkel
markus.morkel@charite.de
49-304-505-36107
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. Experimental Chemo Combo for Colon Cancer Disappoints
3. Targeted therapeutics for colon cancer to be presented at AACR meeting
4. Obese White Women Shying Away From Colon Cancer Screening
5. Diagnostic yield of colonoscopy for melena after nondiagnostic upper endoscopy is lower than previously reported
6. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
7. Physical activity linked to reduced mortality in breast and colon cancer patients
8. Exercise May Boost Survival in Breast, Colon Cancer Patients
9. Common Blood Pressure Drugs May Not Cut Colon Cancer Risk
10. Researchers Test Laxative-Free Colon Scan
11. Blacks, Hispanics Have Higher Colon Polyp Risk Than Previously Thought
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Colon cancer exhibits a corresponding epigenetic pattern in mice and humans
(Date:7/1/2015)... , ... July 01, 2015 , ... Incentivizing the use ... under control, with discounts as much as 80% or 90% off the prices for ... insurers need to act to mitigate the financial impact of these high-cost generic drugs. ...
(Date:7/1/2015)... ... ... The Recovery Workforce Summit: 2015 PRA Annual Conference , presented by ... as a keynote on June 2nd in Philadelphia, PA. Stossel led a timely keynote ... power and reach to the essential message, while opening doors to wellness and recovery. ...
(Date:7/1/2015)... ... July 01, 2015 , ... The executive ... and marketing of a number of nutritional and beauty products, announced the company ... ECRM Diet, Vitamin & Sports Nutrition conference in Tampa, Florida. This specific ECRM ...
(Date:7/1/2015)... ... July 01, 2015 , ... The Thule Atmos X4 offers protection ... to ensure it lived up to Thule’s rigorous standards. Due to its Bi-ComponentArmor and ... Thule owners have come to expect. , The Thule Atmos X4 has ...
(Date:7/1/2015)... ... 01, 2015 , ... AvePoint, the established leader ... a new operational office in Zurich, Switzerland. The new facility will deliver enterprise-level ... business for organizations throughout the Swiss market. , “AvePoint is committed to ...
Breaking Medicine News(10 mins):Health News:Blues Execs Share Strategies for Managing Generic Drug Inflation in AIS Newsletter 2Health News:Blues Execs Share Strategies for Managing Generic Drug Inflation in AIS Newsletter 3Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 2Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 3Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 4Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 5Health News:NPI Executives Report Great Success at ECRM Conference 2Health News:AvePoint Opens Office in Zurich to Meet Increasing Market Demand for Enterprise Collaboration Solutions in Switzerland 2Health News:AvePoint Opens Office in Zurich to Meet Increasing Market Demand for Enterprise Collaboration Solutions in Switzerland 3
... By Alan Mozes HealthDay Reporter , ... every four U.S. health-care workers use some form of ... healthy, a new report shows. What,s more, doctors, ... were actually more likely than the general ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, ... Steve Jobs, tenure as CEO of Apple Inc. was the ... from the iPod to the iPhone to the iPad -- ... he was stepping down as the head of the hugely ...
... By Jenifer Goodwin HealthDay Reporter , THURSDAY, Aug. ... most dreaded afflictions of old age, but the announcement by ... at age 59 has put a spotlight on the less ... , , About 500,000 people in the United States, or ...
... Steven Reinberg HealthDay Reporter , THURSDAY, Aug. ... face higher odds of dying if they,re admitted over ... study finds equally good results for patients treated at ... the so-called "weekend effect" -- an increased risk of ...
... clinic isn,t enough to keep some trauma patients who have ... department (ED) for follow-up care, even for such minor needs ... Johns Hopkins research. Reporting in the Annals of ... Medicare and those with no insurance were 60 percent more ...
... , THURSDAY, Aug. 25 (HealthDay News) -- In ... a tornado, earthquake or fire, most dialysis patients don,t have ... to a new study. Although these kidney-disease patients rely ... University of North Carolina School of Medicine found that many ...
Cached Medicine News:Health News:Many Health-Care Workers Have Turned to Alternative Medicine 2Health News:Many Health-Care Workers Have Turned to Alternative Medicine 3Health News:Steve Jobs Faces Uphill Battle Against Cancer: Experts 2Health News:Steve Jobs Faces Uphill Battle Against Cancer: Experts 3Health News:Coach Summitt's Diagnosis Puts Spotlight on Early-Onset Alzheimer's 2Health News:Coach Summitt's Diagnosis Puts Spotlight on Early-Onset Alzheimer's 3Health News:Coach Summitt's Diagnosis Puts Spotlight on Early-Onset Alzheimer's 4Health News:Specialized Stroke Centers Deliver on the Weekends 2Health News:Specialized Stroke Centers Deliver on the Weekends 3Health News:Uninsured trauma patients are more likely to use the ED for follow-up care 2Health News:Uninsured trauma patients are more likely to use the ED for follow-up care 3Health News:Dialysis Patients Unprepared for Disasters, Study Contends 2
(Date:7/1/2015)... , June 24, 2015 ... the addition of the "2015 Strategies in ... offering. This new 175-page report provides ... including diabetes (strips and meters), pregnancy, ovulation, and ... growth, regulatory requirements, technologies, and competitive profiles. ...
(Date:7/1/2015)... and FT LAUDERDALE, Florida , ... ("OrbusNeich"), a designer, developer, manufacturer and marketer of innovative medical ... on May 13, 2015, it prevailed in a final opposition ... Patent EP 1 341 482 - STENT HAVING HELICAL ELEMENTS ... review in the EPO and has been upheld as a ...
(Date:7/1/2015)... 2015 Dynatronics Corporation (the "Company") (NASDAQ: ... rehabilitation and physical therapy products, announced today that ... led by affiliates of Prettybrook Partners LLC (collectively, ... the healthcare industry. The financing provides Dynatronics with ... potential strategic acquisitions.  "We enthusiastically ...
Breaking Medicine Technology:2015 Strategies in the Home/Self Testing Market 2OrbusNeich Announces Favorable Ruling from the European Patent Office and Initiation of Litigation Against Terumo Corporation 2Dynatronics Announces Completion Of $4,025,000 Private Placement Led By Prettybrook Partners 2Dynatronics Announces Completion Of $4,025,000 Private Placement Led By Prettybrook Partners 3
... Technologies, Inc. (NYSE Amex: PTN ) today announced ... Palatin,s request to begin a Phase 2A proof-of-concept human trial ... administered formulation of PL-3994, an NPR-A agonist compound, in development ... "We are excited about the prospect of advancing PL-3994 into ...
... 3, 2011 Inovio Pharmaceuticals, Inc. (NYSE Amex: ... preventive vaccines against cancers and infectious diseases, announced today that ... company overview at the ROTH 23rd Annual Growth Stock Conference ... A live and archived webcast will be accessible ...
Cached Medicine Technology:FDA Clears Palatin Technologies' IND Filing to Commence Clinical Studies for Asthma 2Inovio Pharmaceuticals to Present at ROTH 23rd Annual Growth Stock Conference 2Inovio Pharmaceuticals to Present at ROTH 23rd Annual Growth Stock Conference 3
Straight shafts with 1 x 2 teeth. Serrated handle with polished finish. Delicate teeth....
Straight shafts with 0.12 mm teeth and 5 mm tying platform. Serrated handle with polished finish. Manufactured in titanium....
Angled 45 degree shafts with 0.5 teeth and 6 mm tying platform. Polished finish....
Angled 45 degree shafts 8 mm long with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Medicine Products: