Navigation Links
Colon cancer exhibits a corresponding epigenetic pattern in mice and humans
Date:2/7/2013

ds of genetic and epigenetic changes at this stage, which complicates the analysis.

The matter is different for the corresponding polyps in mice, which the researchers can investigate considerably earlier following their formation. For this reason, scientists of the Max Planck Institute for Molecular Genetics have now pursued the question of which epigenetic changes in intestinal tumours occur first with the help of a mouse model.

"With mice, we can investigate the first changes much more easily than with humans", says Markus Morkel, who led the study. The scientists analysed the epigenetic changes in a strain of mice with a defective copy of the APC gene. This gene serves as an intestinal tumour suppressor in mice as well as in humans. Accordingly, it has lost its functionality in a majority of patients with colon cancer.

The results displayed a clear picture:The researchers recognised a recurring pattern of more than 13,000 epigenetic changes in all of the mouse tumour samples. By contrast, they did not find this pattern in healthy intestine or in intestinal stem cells, which are the cells of origin of the tumour. Since the mice and hence the tumours were less than three months old, the changes must have already spread shortly after the first genetic mutation in the APC gene within the tumour cells. According to the scientists, the first mutation already leads to pathological activation of numerous enzymes controlling the epigenetic mechanisms.

Remarkably, the molecular biologists discovered large parts of the tumour-specific epigenetic pattern not only in the mouse, but also in human colon cancer tissue. "These initial epigenetic changes could therefore serve as markers and significantly simplify the early diagnosis of colon tumours in the future", hopes Markus Morkel. Patients would merely have to provide a blood sample for the diagnosis and could forego an enteroscopic procedure.


'/>"/>

Contact: Markus Morkel
markus.morkel@charite.de
49-304-505-36107
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. Experimental Chemo Combo for Colon Cancer Disappoints
3. Targeted therapeutics for colon cancer to be presented at AACR meeting
4. Obese White Women Shying Away From Colon Cancer Screening
5. Diagnostic yield of colonoscopy for melena after nondiagnostic upper endoscopy is lower than previously reported
6. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
7. Physical activity linked to reduced mortality in breast and colon cancer patients
8. Exercise May Boost Survival in Breast, Colon Cancer Patients
9. Common Blood Pressure Drugs May Not Cut Colon Cancer Risk
10. Researchers Test Laxative-Free Colon Scan
11. Blacks, Hispanics Have Higher Colon Polyp Risk Than Previously Thought
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Colon cancer exhibits a corresponding epigenetic pattern in mice and humans
(Date:7/12/2014)... July 12, 2014 In ... report, ‘cognitive assessment and training’ is defined ... assess, train, or enhance cognitive functions. These ... as in dementia screening, clinical trials, driver’s ... learning, self assessment, brain training, and employers’ ...
(Date:7/12/2014)... 12, 2014 Tylenol lawsuits ( ... move forward in the federal multidistrict litigation underway ... Bernstein Liebhard LLP reports. According to a filing ... F. Stengel has ordered the deposition of a ... found that the witness’s testimony concerning the marketing ...
(Date:7/12/2014)... 2014 "The second toes cross over the ... to wear shoes," said an inventor from East Hartford, Conn. ... this from happening. , He then created a prototype of ... the second and big toes from overlapping. This avoids discomfort ... Ergonomic and easy to use, it's ideal for people with ...
(Date:7/12/2014)... York (PRWEB) July 12, 2014 As ... move forward in U.S. courts, Bernstein Liebhard LLP notes ... metal ion levels to the failure of metal-on-metal hip ... issue of The Journal of Bone & Joint Surgery, ... unilateral Articular Surface Replacement prostheses at least twelve months ...
(Date:7/12/2014)... “Critical Care Therapeutics in Major ... Four-Factor PCCs and Recombinant Products to Drive Market,” ... market in the US, UK, France, Germany, Italy, ... estimation of market size for 2013, along with ... indications that are being treated using the five ...
Breaking Medicine News(10 mins):Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 2Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 5Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6
... arrested for mailing thousands of anthrax hoax ... mailed to US President George W Bush. ... allegedly threatened to use a weapon of ... that the letters were mailed to government ...
... Pennsylvania school of medicine have found that patients who had ... arteries in head are in the risk of developing a ... Professor Scott Kasner and researchers is to be published in ... may help in early detection of second stroke and it ...
... Indian State of Kerala fell ill and were admitted to ... // District Collector N. Ayappan said the condition of the ... and Government School at Manacuad, are stable. The district administration ... free meal scheme, and the chances of sabotage have not ...
... caused in human beings due to an excessive use ... which are useful to human beings. // This causes ... who have been undergoing treatment with antibiotics. ... life-threatening complications. But scientists say it has also begun ...
... Engineering Center (IEEC) of the Binghamton University has ... the New York State Office of Science, Technology ... of the Microelectronics Research in the roll-to-roll format. ... funding such initiatives, recognized by the New York ...
... meeting with Boston Scientific to talk about the repairs in ... held in 2001 with Schering-Plough // about problems with its ... to make any amendments. This provoked the FDA to withhold ... solve this problem Raul E. Cesan, the company's president and ...
Cached Medicine News:Health News:$ 1.7 Million NYSTAR Award for Binghamton University to Flex Electronics Research Muscle. 2
(Date:7/10/2014)... 11. Juli 2014  Dilon Technologies, ... die molekulare Bildgebung, einschließlich molekularer Bildgebung ... CE-Zulassung für sein Navigator ® -Gamma-Sondensystem ... das Produkt jetzt europaweit vertreiben. Dilon ... der europäischen Länder ausgedehnt und bereits ...
(Date:7/10/2014)... SAN DIEGO , July 10, 2014  RESMED INC. ... report its fourth quarter and fiscal year ended June 30, ... York Stock Exchange market close. A press release with ResMed,s ... and the company will host a webcast to discuss operating ... scheduled to begin at 1:30 p.m. US Pacific Time and ...
(Date:7/10/2014)... , July 10, 2014   Ventana Medical Systems, ... announced it has entered into an agreement with Merck ... as EMD Serono in the United States ... collaborate with Merck KGaA,s biopharmaceutical division on the development ... undisclosed target using Ventana,s proprietary diagnostic assays. In alignment ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... Pro Osteon Bone Graft Substitutes a natural ... from cadaver bone, but such grafts may ... disease transmission. Interpore Cross has developed the ... to address these needs, offering surgeons a ...
... Healos is an osteoconductive matrix constructed ... fully coated with hydroxyapatite through a ... with autogenous bone marrow aspirate, Healos ... cell attachment, proliferation and differentiation. The ...
Weitlaner-Locktite retractors, blunt, 11 cm total length....
Sharp Weitlaner Retractor....
Medicine Products: