Navigation Links
Collagenase for Dupuytren's contracture: Added benefit not proven
Date:7/12/2012

Collagenase extracted from Clostridium histolyticum (trade name: Xiapex) was approved in the beginning of 2011 for the treatment of people with Dupuytren's contracture. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether collagenase offers an added benefit in comparison with conventional regimens. However, such an added benefit cannot be inferred from the dossier, as the drug manufacturer presented either no data or unsuitable data.

Collagenase is to break down thickened connective tissue fibres

Dupuytren's contracture is a disorder of the hand in which connective tissue fibres in the palmar side of the hand (fasciae) thicken and harden. As a result, one or several fingers become permanently bent and can no longer be straightened. Collagenase is injected into the lesions to break down the thickened connective tissue fibres. One day later, the rupture of these fibres through passive digital extension is attempted in order to restore the stretching ability of the affected finger.

G-BA specifies different comparator therapies depending on disease stage

When specifying the appropriate comparator therapy, the Federal Joint Committee (G-BA) assumed that the choice of (conventional) treatment depends on how severely the function of the fingers and hand is impaired.

Hence, the G-BA stipulates four treatment alternatives and assigns them to different disease stages. The appropriate comparator therapies are specified as follows:

  • no treatment" in stage N, where no contracture yet exists;
  • percutaneous needle fasciotomy" (PNF), a minimally invasive technique, in stages N/I, I and II;
  • partial fasciectomy" (PF), open surgery of the hand, in stages III and IV.

If PF is not suitable for advanced-stage patients, a PNF can be p
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
49-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Abiraterone: Indication of considerable added benefit in certain patients
2. Nurse Alert Provides Added Level of Senior Alert Care With New Nurse Triage Feature
3. Tafamidis: Approval denotes proven added benefit
4. No Added Cancer Risk From Hip Replacement Materials: Study
5. Platelet drug shows clinical benefits for severe, unresponsive aplastic anemia
6. Green Tea Weight Loss Results and Health Benefits Revealed
7. Early Surgery May Benefit Some With Heart Infection
8. How much would our health benefit from leaving the car at home?
9. MTSS-mba Membership Benefits Administration Software for Private and Taft-Hartley Employee Benefit Funds Releases New Pension Modules
10. Some Diabetics May Not Benefit From Daily Aspirin
11. Tai Chi increases brain size, benefits cognition in randomized controlled trial of Chinese elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... According to WFLA on ... of heroin use and eventual overdoses. Thricefold deaths have held steady over the last ... on the Sarasota heroin epidemic, which was spurred by the crackdown of prescription painkillers. ...
(Date:7/31/2015)... ... ... Physical therapy for knee osteoarthritis is an important part of knee pain ... from doing what they want or need to do. The patient may have trouble getting ... patient's exercise regime may be limited by the pain in their knee. When a patient ...
(Date:7/31/2015)... ... July 31, 2015 , ... A family-run business ... oils from ingredients sourced all over the world, then manufactured into specific formulations ... have developed the highest-quality oils in the industry, which we are bringing to ...
(Date:7/31/2015)... ... ... “ Crack’em ” was featured on NewsWatch as part of its monthly ... Forstrom, a technology expert and special reporter for NewsWatch, conducted the review and shared ... can be a very messy experience, especially when cracking eggs. Cracking an egg is ...
(Date:7/31/2015)... ... July 31, 2015 , ... Nutritional ... variety of nutritional and wellness products, announced the addition of Vincent Aquilino to ... therapy, active isolated stretching and the prevention and rehabilitation of injuries, has spent ...
Breaking Medicine News(10 mins):Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 2Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 3Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 2Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 3Health News:Living Pure Essential Oils takes Therepeutic Essential Oil Market by Storm 2Health News:Make Less Mess while Cooking with Crack’em 2Health News:NPI Welcomes Vincent Aquilino to Board of Directors 2
... that pet animals also require regular exercise like human beings. ... 30 to 45 minutes, according to him.// He went on ... suffered from obesity. ,'Obese dogs have an ... Corriveau adding 'both dogs and cats are at increased risk ...
... was not accepted to donate his sperm. The health policy does ... policy makers feel that Gay man are most prone to homosexuality ... of the virus.// ,The Gay man is not happy ... and does not accept the fact that Gay man indulge in ...
... be improved through the consumption of fizzy soft drinks, according ... Glasgow Caledonian University have revealed that drinking the equivalent //of ... a fifth and combat dementia in older people. ... said people studying for exams could benefit from increasing the ...
... twist to the tale of bird(flu) the country in question, ... to// cover up the issues. ,They say that ... fight against a virus that has killed four Turkish children. ... “It is unofficially known that this illness exists in our ...
... Researchers at the University of North Carolina (UNC) at Chapel ... the lungs of patients affected by cystic fibrosis (CF). Hypertonic ... of the salt. ,The researchers arrived at this ... two weeks., They found that inhaling the salt solution improved ...
... experts have warned that the new wristwatch invented by South ... can turnout to be a health hazard. They have warned ... HIV/AIDS.// There are some who have also expressed doubts if ... ,'In my mind it's a potential public health ...
Cached Medicine News:
(Date:7/30/2015)... special edition of #MedicareMonday on Medicare,s 50 th anniversary. As Medicare celebrates 50 ... highlighting the success of the prescription drug benefit, commonly referred to as Part D. ... and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... VANCOUVER , July 30, 2015  OncoGenex ... it will report its second quarter 2015 financial results ... a conference call and live webcast at 4:30 p.m. ... clinical development programs and a general corporate update. ... the Investor Relations page of the OncoGenex website at ...
(Date:7/30/2015)... N.J., July 30, 2015 PTC Therapeutics, Inc. ... and reported financial results for the second quarter ending ... on many fronts across the organization.  We are excited ... muscular dystrophy clinical trial ever conducted with topline results ... Ph.D., Chief Executive Officer, PTC Therapeutics, Inc. "Translarna is ...
Breaking Medicine Technology:Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10
... MILPITAS, Calif., May 5, 2011 AmbiCom ... wireless products for medical equipment suppliers, today announced that ... investor relations consulting firm, to develop and implement a ... strengthen its relationships with the investment community. ...
... SAN MATEO, Calif., May 5, 2011 NeurogesX, Inc. (NASDAQ: ... and commercializing novel pain management therapies, announced today that Anthony ... at the 10th Annual JMP Securities Research Conference, to be ... , 10th Annual JMP Securities Research Conference Date : ...
Cached Medicine Technology:AmbiCom Retains Hayden IR to Develop Strategic Investor Relations Program 2AmbiCom Retains Hayden IR to Develop Strategic Investor Relations Program 3NeurogesX to Present at 10th Annual JMP Securities Research Conference 2NeurogesX to Present at 10th Annual JMP Securities Research Conference 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: