Navigation Links
Collaborative Drug Discovery, Inc. and St. Jude Children's Research Hospital Make Malaria Research Data Available to Speed Drug Development
Date:10/11/2007

compounds and the results of studies on their biochemical activity in animals, data on how they work in the body, how long they last, and other pharmacological data, in addition to their level of toxicity. The results of the animal studies represent one of the largest sets of published data on the structure-activity relationship (SAR) of molecules against a single disease, Guy said. SAR refers to the link between a molecule's specific structure and the biological effect it has because of that structure.

CDD scanned the information from the original publication into a computer database and organized it into a format that can be read, searched and shared. This more convenient format will enable St. Jude scientists to use the information to develop models of new anti-malaria drugs and predict their efficacy, toxicity, and how the body will respond to them.

Based on such models, St. Jude researchers are conducting a comprehensive analysis of "relevant chemical space" of these molecules, something that has never before been done for malarial drug research, Guy said. Relevant chemical space refers to the study of individual families of molecules whose members all share a similar structure that holds promise for a specific therapeutic use. Concentrating on only certain families of molecules likely to have the desired effect saves time and speeds the discovery of the few molecules most likely to have all the characteristics needed for an effective anti-malaria drug, he said.

The anti-malarial drug study is the first of several planned by CDD to help the research community discover drugs for orphan infectious diseases-disorders for which there is little commercial interest in developing drugs. Future CDD communities are planned in other more commercial areas, such as cancer research and selected gene families.

To access this historical set of Malaria Animal SAR data for the first time, either visit

SOURCE Collaborative Drug Discovery, Inc.; St. Jude Children'sResearch
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. WHO And China Set Up Collaborative Center For Fighting Bird Flu
2. Collaborative use of Imaging Techniques proved effective in Cardiovascular Diagnosis – ESC Recommend
3. Medarex Announces Collaborative Research Agreement With Mitsubishi Pharma
4. Tuberculosis – 125 Years Since Discovery, Yet a Challenge to Dat
5. RSV Hits Winnipeg Childrens Hospital
6. Coverage for Childrens Mental Illness Reduces Out-of-Pocket Spending
7. Childrens Health Program Covering More Adults Than Children
8. Nutritious Diet Help Improve Childrens Academic Performance
9. Kidney Stones - Interesting New Research implicates bacteria as its cause
10. Stem cell research- now Nobel Laureates join the debate
11. Researchers urge caution in using ear tube surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 22, 2014 Getting breast implants is ... completely optional or due to medical necessity. Either way, women ... to prepare for it, says Robert Kraft, MD, Plastic Surgeon ... implant removal surgeries are performed each year in the United ... 70 percent of those procedures stem from three main problems: ...
(Date:7/22/2014)... Southlake, TX (PRWEB) July 22, 2014 ... proving to address skin laxity with results that are ... opposed to topically treating the skin with radio frequency, ... probes which are inserted under the skin to “inject” ... studies have shown that this single treatment solution for ...
(Date:7/21/2014)... (PRWEB) July 22, 2014 On Monday, September ... Charity Golf Outing honoring Mike McGuriman-Motorola Solutions at The Knoll ... outing begins with registration and lunch at 11 a.m. ... and prizes. Price increases to $250 after September 7th. ... for $100 per person. The dinner will include a ...
(Date:7/21/2014)... (PRWEB) July 21, 2014 PowerObjects, ... service, support, education, and add-ons for Microsoft Dynamics ... Inner Circle, an elite group of the most ... with sales achievements that rank them in the ... of partners. Members of the Microsoft Dynamics Inner ...
(Date:7/21/2014)... human nature to hate losing. , Unfortunately, it,s ... abandoning a solid strategy and thus increasing your chances ... conclusion of a Brigham Young University study published this ... finding is based on an analysis of two decades ... focused on whether coaches adjusted their personnel following games ...
Breaking Medicine News(10 mins):Health News:Is Breast Implant Removal Right for You? Plastic Surgeon Dr. Robert Kraft With Advanced Dermatology, PC Explains Breast Implant Removal and Offers Tips On Procedure 2Health News:Is Breast Implant Removal Right for You? Plastic Surgeon Dr. Robert Kraft With Advanced Dermatology, PC Explains Breast Implant Removal and Offers Tips On Procedure 3Health News:New Minimally Invasive Procedure, ThermiTight, “Injects” Radio Frequency to Treat Skin Laxity 2Health News:7th Annual Push to Walk Golf Outing to Be Held September 22nd 2Health News:PowerObjects Joins the 2014 Microsoft Dynamics Inner Circle 2Health News:'Moral victories' might spare you from losing again 2
... HealthDay Reporter , TUESDAY, May 17 (HealthDay News) ... birth defects in women taking these drugs during the first ... the drugs are relatively new, further studies are needed to ... In a large study of children born in Denmark, ...
... City, the prevalence of asthma among children entering school ... children growing up within walking distance of each other ... asthma. In the first comprehensive effort to understand ... Mailman School of Public Health compared the household presence ...
... . , Pediatric and young adult leukemia and ... the Cole Foundation,s announcement that it would provide more than ... four McGill University young scientists. "The Cole Foundation is dedicated ... the age of 25, and the research projects we finance ...
... from Boston University School of Medicine (BUSM) have discovered ... syndromes. The team connected pharmacological properties of the Novartis ... for the first time after investigating adverse reactions suffered ... treatment of osteoporosis. These findings appear online in the ...
... -- A gene variation that causes faulty cholesterol regulation also ... may be a reason why some women can,t get pregnant, ... more than 200 infertile women who were undergoing in vitro ... the scavenger receptor class B type 1 (SCARB1) gene. ...
... the intermittent interruption of breathing that occurs in patients with ... cells and increased tumor growth in mice, according to researchers ... mouse models tended to contain more dead cells, indicating a ... the study will be presented at the ATS 2011 International ...
Cached Medicine News:Health News:Newer Epilepsy Meds Less Likely to Cause Birth Defects: Study 2Health News:Newer Epilepsy Meds Less Likely to Cause Birth Defects: Study 3Health News:Cockroach allergens in homes associated with prevalence of childhood asthma in some neighborhoods 2Health News:Cole Foundation injects $700,000 into childhood cancer research 2Health News:Gene Variation May Explain Some Female Infertility Cases 2Health News:Obstructive sleep apnea linked to cancer growth in mice 2Health News:Obstructive sleep apnea linked to cancer growth in mice 3
(Date:7/21/2014)... ANGELES , July 21, 2014 /PRNewswire/ ... Agency (LOPA) is utilizing the CompuMed, Inc. ... Solution to improve donor organ recovery. CompuMed ... to provide real-time access to its Board-Certified ... care consulting.      (Logo: http://photos.prnewswire.com/prnh/20140721/697628) ...
(Date:7/21/2014)... AVIV, Israel , July 21, 2014 ... a clinical-stage biopharmaceutical company focused on the development and ... of liver diseases and cholesterol gallstones, announced today that ... Friday, July 25, 2014 to discuss results for the ... update on current developments with respect to its clinical ...
(Date:7/21/2014)... 21, 2014 Integrity Applications, Inc. (OTCQB: ... GlucoTrack ® model DF-F noninvasive blood glucose ... through its wholly-owned subsidiary, Integrity Applications Ltd., into ... arm of Acer Inc.  Pursuant to the agreement, ... a non-exclusive basis) the GlucoTrack Model DF-F and ...
Breaking Medicine Technology:Louisiana Organ Procurement Agency Leveraging CompuMed to Secure More Donor Hearts 2Louisiana Organ Procurement Agency Leveraging CompuMed to Secure More Donor Hearts 3Galmed Pharmaceuticals Second Quarter 2014 Conference Call and Webcast Scheduled for Friday, July 25, 2014 2Integrity Applications, Inc. Enters into Manufacturing Agreement with Wistron Corp. 2Integrity Applications, Inc. Enters into Manufacturing Agreement with Wistron Corp. 3
... N.J., Sept. 13 Soligenix, Inc. (Soligenix or the ... late-stage biopharmaceutical company, announced today that its President and ... a company overview highlighting recent developments at the Rodman ... City.  The presentation will take place on Wednesday, September ...
... Sutter Health today announced a donation of $100,000 to the ... in relief efforts following a destructive fire in San Bruno ... is made on behalf of the Northern California network,s employees, ... donated by Sutter-affiliated California Pacific Medical Center (CPMC). ...
Cached Medicine Technology:Soligenix to Present at the Rodman & Renshaw Healthcare Conference on September 15, 2010 at 10AM EDT 2Soligenix to Present at the Rodman & Renshaw Healthcare Conference on September 15, 2010 at 10AM EDT 3Sutter Health Network Donates $150,000 to Aid Victims of San Bruno Fire 2
... Helmer PC1200 Platelet Incubators ... your laboratory counter top. These ... institution to have the security ... environment without taking up a ...
The PC4200i is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
... rotators and agitators for continual ... set at 22C (71F) or ... (59F to 104F). Uniformity is ... bottom. Recorder is standard on ...
An enzyme-linked immuno-sorbent assay for the detection and quantitation of anti-tissue Transglutaminase in serum of patients with Celiac Disease and Dermatitis Herpetiformis....
Medicine Products: