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Collaborative Drug Discovery, Inc. and St. Jude Children's Research Hospital Make Malaria Research Data Available to Speed Drug Development
Date:10/11/2007

SAN FRANCISCO, Oct. 11 /PRNewswire/ -- Collaborative Drug Discovery, Inc. (CDD, Inc.) and St. Jude Children's Research Hospital have joined together for a project aimed at speeding the development of new drugs to overcome resistant strains of malaria.

The collaboration combines the malaria drug data and informatics technology of CDD with the drug discovery expertise of the St. Jude Department of Chemical Biology and Therapeutics. Informatics is the use of computer hardware and software to extract and manage knowledge from large databases.

"CDD's databases will probably help us reduce the number of potential molecules we'll need to analyze from tens of millions down to hundreds of thousands," said Kip Guy, Ph.D., chair of the St. Jude Department of Chemical Biology and Therapeutics. "Our own screening capability will significantly reduce that to a much smaller number of promising compounds. This will be a widely used database. We are already making the data freely available through CDD so that other researchers can use different analytical strategies to identify potential new anti-malarial drugs."

The collaboration is designed to help scientists quickly screen millions of chemicals, based on their structure and their chemical and biological properties, to find those that are most likely to make effective anti-malaria drugs. The key to this quest to find the drug "needle in the haystack" is the enormous two-volume collection of data from studies on malarial drugs published by the U.S. Army in 1946.

This 61-year-old publication, "A Survey of Malaria Drugs," was originally edited by Frederick Y. Wiselogle and had contributions from a number of leading researchers of the time. The two-volume set was designed to help researchers develop effective anti-malarial drugs; and to serve as a model for how scientists could develop drugs for other infections, according to the authors of that publication. The collection presents the structures of many
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SOURCE Collaborative Drug Discovery, Inc.; St. Jude Children'sResearch
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