Li Li, MD, PhD, associate professor of Family Medicine, Epidemiology & Biostatistics and associate director for Prevention Research, Case Comprehensive Cancer Center, Case Western Reserve University, is the co-investigator. Wei Xin, MD, PhD, assistant professor of Pathology, is the collaborator.
Lynn DeGregorio, president of the DeGregorio Family Foundation, based in New York City, said, "The foundation has always sought to fund research that is innovative and will be a catalyst to collaboration. The application from the Case Western Reserve University School of Medicine will increase the depth and breadth of research into these malignancies, and so we were excited to be able to make this award possible."
Pizarro's funded proposal, entitled, "Role of the novel IL-1 family member, IL-33, in the gastritis-metaplasia-carcinoma sequence," was the only proposal of 24 international applicants selected for funding in the third annual DeGregorio Foundation Award for Cancers.
Stomach cancer, which caused over 10,000 deaths in the United States in 2012 according to the National Cancer Institute, is the second-most common cause of cancer-related mortality, behind only lung cancer. And less than 10 percent of patients diagnosed with esophageal cancer will survive longer than 5 years.
Today, stomach and esophageal cancers are treated as orphan diseases despite their prevalence and deadliness. Together, more than 1.3 million people will be diagnosed with an upper GI malignancy annually, according to NCI.
|Contact: Christine A. Somosi|
Case Western Reserve University