Navigation Links
Cold sore linked to mutation in gene, study suggests
Date:9/16/2013

Why some people are troubled by cold sores while others are not has finally been explained by scientists.

Cold sores affect around one in five people but, until now, no one has been sure why some are more prone to the virus that causes them.

Researchers at the University of Edinburgh have found that people affected by cold sores have a mutation in a gene, which means their immune system is not able to prevent them from developing.

Cold sores are caused by a strain of the herpes simplex virus herpes simplex virus type 1 (HSV-1). Between 80 and 90 per cent of people are infected with the virus, but only about a quarter of them get frequent cold sores.

Scientists analysed thousands of genes to identify which ones expressed the proteins needed by the body's immune system to prevent the virus from becoming active and as a result cold sores from developing.

They then looked at blood samples from people with cold sores and found that one of the genes previously identified IL28b was mutated.

This genetic mutation means that the body is not able to mount an adequate immune response to the virus, which results in cold sores.

The gene identified is also linked to treatment responses for hepatitis C patients. If this gene is mutated, patients are less likely to respond as well to treatment. The link is further evidence that a single genetic mutation can be linked to different viruses.

The study, published in the journal Plos Pathogens, was funded by the Medical Research Council, the Biotechnology and Biological Sciences Research Council, the Wellcome Trust and the European Union.

Professor Juergen Haas, of the University of Edinburgh's Division of Pathway Medicine, said: "Most people carry the cold sore strain of the herpes simplex virus, but until now we never knew why only some of them develop cold sores.

"Knowing that susceptibility to the virus involved relates to people's genes reinforces the need to research, not only the evolution of viruses themselves, but also the susceptibility of hosts to infection."


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Antibiotics Linked to Retinal Detachment Risk
2. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
3. Pharmacy Robots Linked to Bacterial Contamination of Drugs
4. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
5. Dental X-Rays May Be Linked to Benign Brain Tumors
6. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
7. Huntingtons Disease Linked to Reduced Cancer Risk in Study
8. Study finds significant skull differences between closely linked groups
9. Researchers Map Brain Regions Linked to Intelligence
10. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
11. Anxiety Linked to Smarts in Brain Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... 05, 2016 , ... In order to increase comfort, convenience ... a Seattle-based steam bath and sauna manufacturer recently launched amerecConnect™ , a ... the app, developed for both smartphones and personal computers perfectly emulates that of ...
(Date:5/5/2016)... ... May 05, 2016 , ... In honor of National Nurses Week 2016, ... over the United States to thank a nurse who's made a difference in their ... to the American Red Cross of San Diego/Imperial Counties (up to $10,000) every time ...
(Date:5/5/2016)... CA (PRWEB) , ... May 05, 2016 , ... ... may not seem like an intuitive activity to alleviate the pain that’s a ... effective in improving pain and function in people with arthritis. , “Physical ...
(Date:5/5/2016)... , ... May 05, 2016 , ... Chronic stress can ... constant presence, it can weaken the immune system and increase inflammation, both of which ... director of the adult congenital heart disease program at Harvard-affiliated Massachusetts General Hospital. Chronic ...
(Date:5/5/2016)... Rochester, NY (PRWEB) , ... May 05, 2016 ... ... app is now available for iOS and Android devices. VisualDx is the ... expanded to include diagnostic support across general medicine. The system speeds diagnosis, ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 ... addition of the  "Global Acute Myeloid Leukemia ...  report to their offering.       ... Acute Myeloid Leukemia Market and Competitive Landscape ... Myeloid Leukemia pipeline products, Acute Myeloid Leukemia ...
(Date:5/3/2016)... , May 4, 2016 Research ... "Global Cancer Stem Cell Therapy Market Outlook 2020" ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,Recombinant technology has improved significantly ... expected to be developed in coming years. Many cancer ... Cancer stem cell therapies are also expected to be ...
(Date:5/3/2016)...  While you may be familiar with watching a film or TV show in high definition, ... 8MP in the Medical Industry.  Ampronix  is a renowned authorized reseller of the medical industry,s ... - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: