Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to... (tic raw material is not DNA but rather R...)

Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce

Date:5/23/2008

tic raw material is not DNA but rather RNA, and before they can begin to replicate, they must first convert their RNA into DNA, using a special enzyme that they encode, called reverse transcriptase.

Once its RNA has been reverse-transcribed into DNA, the virion, having invaded a cell whose genetic material consists of DNA, can shed its protein coat and immediately proceed to integrate its newly converted DNA -- containing 9 genes -- into the host cells DNA. In this way the virion effectively hijacks the cell and reproduces itself whenever the cell reproduces.

Dr. Skowronski has devoted years to the study of various molecular factors -- think of them as assistants -- that immune-deficiency viruses employ to perform a range of essential tasks. The idea behind his approach is to understand with great precision all of the details of the processes by which the virus lives and propagates, as a means of identifying points of vulnerability, where drugs might be inserted to foul up the works.

In the research just completed, results of which appeared in PLoS Pathogens on May 9, Skowronski and his team focused on a so-called accessory protein called Vpx (Viral protein x). Prior studies had shown that Vpx was produced by simian, as well as a subset of human, immunodeficiency viruses, and was somehow active at the heart of their reproductive processes in a subset of immune cells called macrophages. The question was how, and to what effect.

How Vpx Enables the Virus to Replicate

Macrophages are central players in the mammalian immune system. Immune-deficiency viruses are devastating because they specifically seek out, invade, and commandeer the machinery of these particular cells -- macrophages, dendritic cells, helper T-cells -- which protect the mammalian system from foreign invaders.

Skowronski and colleagues knew from prior work that Vpx was a key enabler: it somehow facilitated an early event in the viral
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

0

GOOD

Page: 1 2 3 4
Related medicine news :

1. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
2. Adult offspring of parents with PTSD have lower cortisol levels
3. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
4. Parents PTSD May Boost Stress in Offspring
5. Partnership for a Drug-Free America and Colorado Springs Police Department Introduce Methamphetamine Prevention Program to Colorado Law Enforcement
6. International Consulting Firm Health Fitness Dynamics Hired to Oversee Springbrook Inns Planned New Spa
7. COLORBLENDS to Donate Portion of Sales of Spring Forward Daffodil Blend to the Christopher and Dana Reeve Foundation
8. Springer adds Advances in Therapy to journals portfolio
9. Lifespring Health Promotes Health and Fitness by Sponsoring Silicon Valley Marathon on November 3rd and 4th
10. Announcing Always Best Care Senior Services Expansion into Colorado Springs, Colorado
11. Cold Spring Harbor scientists devise novel, low-cost method of sifting genomes high-value regions

Post Your Comments:

(Date:12/16/2009)... to disease , , WEDNESDAY, Dec. 16 (HealthDay News) ... leprosy have been identified by scientists in Singapore ... than 10,000 DNA samples from leprosy patients and ... the important role that the innate immune response ... leprosy is not common, the discoveries have significant ...

(Date:12/16/2009)... could help ease health and environmental concerns about the ... for changing the behavior of nanoparticles in municipal sewage ... Their study was published in ACS, journal Environmental ... UK Centre for Ecology and Hydrology and colleagues note ... nanoparticles particles less than 1/1000th the width of ...

(Date:12/16/2009)... Planet-Friendly Organics, Solar-Powered Manufacturing and Sustainable Packaging at an Affordable ... ... Angeles, CA (PRWEB) December 16, 2009 -- Actively healthy families ... all natural skin care for their children as Episencial ... featuring the beloved artwork of The Very Hungry Caterpillar from ...

(Date:12/16/2009)... caution, though, that no direct link has been found, ... bacteria in food -- commonly linked to food poisoning ... might also be the cause of some urinary tract ... the bacteria in chicken from stores and restaurants and ... evidence that the germs were transmitted directly to the ...

(Date:12/16/2009)... and MassBio promote Massachusetts companies through annual marketing campaign ... ... 2009 -- BioSpace unveiled the 2010 Genetown™ Hotbed Campaign ... , , , ,Genetown is sponsored by MassBio ... device industries. The campaign places each entity’s brand on an ...

Breaking Medicine News(10 mins):Health News:Leprosy Genes Identified 2 Health News:Behavior modification could ease concerns about nanoparticles 2 Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 2 Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 3 Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 4 Health News:New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" 5 Health News:Foodborne E. Coli Suspected in Urinary Tract Infections 2 Health News:Foodborne E. Coli Suspected in Urinary Tract Infections 3 Health News:Thriving Bioscience Region Leaves Its Mark 2

[0] Leprosy Genes Identified [0] Behavior modification could ease concerns about nanoparticles [1] New from Episencial: All Natural, Actively Healthy Skin Care for Babies, Kids and Planet Features Eric Carle's "The Very Hungry Caterpillar" [0] Foodborne E. Coli Suspected in Urinary Tract Infections [0] Thriving Bioscience Region Leaves Its Mark

... CHAPEL HILL, N.C., Sept. 13 "Profit, customers and,people ... the conference,Human Capital Management: Facing the Challenges of the ... taking care of your people, your people,will take care ... of your,business." At the recent HR-focused conference of ...

... now under development could enhance the design of sports ... sporting potential. , The models, more sophisticated and more ... produce unprecedentedly realistic simulations of how potential ball designs, ... , This data can then be harnessed by sports ...

... N.J., Sept. 12 The following is,a statement issued by ... CASSIDY, ON BEHALF OF ROSA ACUNA, RE: ... V. TURKISH, Today,s opinion is a stunning and surprising, ... Jersey. The opinion represents a,significant departure, in our judgment, from ...

... /PRNewswire-FirstCall/ - Transition Therapeutics Inc.,("Transition" or the ... developing therapeutics for disease indications,with large markets, ... year,ended June 30, 2007. Selected Highlights ... up to the date of this press ...

... EPI-Q, a leading healthcare,management consulting firm, announces today ... key appointment. EPI-Q, Inc. specializes in assisting life,sciences ... outcomes,and cost-effectiveness of patient care. Andrew Baker ... NY. Mr. Baker will have responsibility for global ...

... BEDFORD, Mass., Sept. 12 Hologic, ... of state-of-the-art diagnostic and,digital imaging systems directed ... statement, including a joint proxy,statement/prospectus, for a ... ), has become effective. The Company will ...

Broker a Suite of Research & Advisory Services to Enhance Human Resources Computer models help raise the bar for sporting achievement Historic Abortion Case; Acuna V. Turkish Transition Therapeutics Announces Fiscal 2007 Year End Financial Results EPI-Q Opens East Coast Office and Appoints Vice President-Business Development Hologic Sets Special Meeting of Stockholders to Vote on Proposed Merger with Cytyc Corporation

(Date:12/16/2009)... NASHVILLE, Tenn. , Dec. 16 ... medical cost management services, today commended two new ... from CT scans and other diagnostic imaging tests. ... essential to proper diagnosis and treatment," said Gregg ... these new studies offer more compelling evidence that ...

(Date:12/16/2009)... -- Wound Management Technologies, Inc. (OTC Bulletin ... specialty medical products, announced today that its ... productization of its patented orthopedic bone void ... to be introduced in Q3 2010, to ... multi-billion dollar international market. ,, "Resorbable Orthopedics ...

(Date:12/16/2009)... A new application developed ... clinical review of specialty pharmaceuticals has increased health ... reviewed while reducing costs. ,, AIM, a leading ... health plan clients representing over 35 million consumers ... WLP ), adapted the successful clinical ...

Breaking Medicine Technology:MedSolutions Applauds Renewed Focus on the Dangers of Radiation Exposure 2 MedSolutions Applauds Renewed Focus on the Dangers of Radiation Exposure 3 Wound Management Technologies, Inc. Targets Multi-Billion Dollar Biomaterials Market; Releases Update on Resorbable Orthopedics 2 Wound Management Technologies, Inc. Targets Multi-Billion Dollar Biomaterials Market; Releases Update on Resorbable Orthopedics 3 American Imaging Management's New Specialty Drug Program Delivers Immediate Results 2 American Imaging Management's New Specialty Drug Program Delivers Immediate Results 3 American Imaging Management's New Specialty Drug Program Delivers Immediate Results 4 NCR Embeds DigitalPersona U are U 28R 29 4500HD Fingerprint Sensor in New NCR RealPOS 28TM 29 70XRT Point of Sale Workstations 10017 1 NCR Embeds DigitalPersona U are U 28R 29 4500HD Fingerprint Sensor in New NCR RealPOS 28TM 29 70XRT Point of Sale Workstations 10017 2 45 000 excess deaths annually linked to lack of health insurance 3A Harvard study 57890 1 45 000 excess deaths annually linked to lack of health insurance 3A Harvard study 57890 2 Boston Scientific PROMUS 28R 29 and First Generation TAXUS 28R 29 Express 28R 29 Stents Continue Excellent Performance in SPIRIT III Trial 57889 1 Boston Scientific PROMUS 28R 29 and First Generation TAXUS 28R 29 Express 28R 29 Stents Continue Excellent Performance in SPIRIT III Trial 57889 2 Boston Scientific PROMUS 28R 29 and First Generation TAXUS 28R 29 Express 28R 29 Stents Continue Excellent Performance in SPIRIT III Trial 57889 3 Boston Scientific PROMUS 28R 29 and First Generation TAXUS 28R 29 Express 28R 29 Stents Continue Excellent Performance in SPIRIT III Trial 57889 4

[0] MedSolutions Applauds Renewed Focus on the Dangers of Radiation Exposure [0] Wound Management Technologies, Inc. Targets Multi-Billion Dollar Biomaterials Market; Releases Update on Resorbable Orthopedics [0] American Imaging Management's New Specialty Drug Program Delivers Immediate Results

... Diabetes Therapy Also Improved Glucose ... Day, SAN FRANCISCO, June 9 Amylin Pharmaceuticals,Inc. ... LLY ), and Alkermes, Inc.,(Nasdaq: ALKS ) ... showed the durable efficacy of exenatide once weekly, a,long-acting ...

... long-term, large-scale and,independent studies evaluating cardiovascular (CV) outcomes ... 9,300 patients taking AVANDIA(R),(rosiglitazone maleate) and provide more ... The Veterans Affairs Diabetes Trial,(VADT), through two separate ... is no evidence to suggest that use of ...

After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008 Two Large, Independent Outcomes Trials Offer New Important Safety Information on Cardiovascular Effects of AVANDIA(R)

The TBR-360-1-GD is a large capacity upright style operating temperature +4C. It is specially designed refrigerators for the storage of blood in standard 500ml bags, complying with Australian Standar...

... precise requirements of blood banking and ... Equipment meets American Association of Blood ... (ANRC) and U.S. Food & Drug ... and platelet incubators feature alarm systems ...

Refrigerator specially designed for the storage of blood in standard 500ml bags, complying with Australian Standard AS3864 1997....

TBR-120-1-GD is large capacity upright style refrigerator with an operating temperature of +4C. It is a specially designed refrigerator for the storage of blood in standard 500ml bags, complying with...

Medicine Products:

Blood Storage Refrigerator TBR-360-1-GD Blood Bank Refrigerator 3626 Blood Storage Refrigerator TBR-160-1-GD Blood Storage Refrigerator TBR-120-1-GD

Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to...(tic raw material is not DNA but rather R...),Health