Navigation Links
Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce
Date:5/23/2008

A team of scientists at Cold Spring Harbor Laboratory (CSHL) has discovered new details about how a simian strain of the AIDS virus replicates. The findings are significant because they suggest new strategies to prevent replication, and because they are applicable to human strains of the virus, which, despite the persistent efforts of scientists over two decades, can only be slowed by drug treatments but neither cured nor prevented.

Jacek Skowronski, Ph.D., CHSL associate professor, led a team that studied a virulent strain of simian immune-deficiency (SIV) virus called SIVsm/mac, named for two species of monkeys in which it occurs, sooty mangabeys and macaques. The team included members of Dr. Skowronskis CSHL lab and researchers at Stowers Institute for Medical Research in Kansas City, Missouri, and the Skirball Institute of Biomolecular Medicine in New York City.

Like versions of the virus that occur in humans, SIV viral particles, or virions, are composed of a few fundamental parts. At their heart are two identical but separate strands of RNA surrounded by a protective envelope of roughly 2,000 proteins called a capsid.

This tiny, conical capsule, in turn, is surrounded by multiple defensive rings, somewhat like the walls of a medieval city. Immediately surrounding it is a protective protein shell, or matrix, and beyond it a formidable double-walled viral envelope. Poking through the outer envelope are the viral equivalent of grappling hooks, protein molecules designed to lock onto receptors on the surface of the unfortunate cell that the virus will attach to and then invade.

Viruses Hijack Living Cells to Reproduce

Viruses, unlike cells, are not living things. They must penetrate a living cell and commandeer its internal machineries in order to reproduce. HIV and its simian cousin SIV are members of a viral subspecies called retroviruses that invert the usual reproductive procedure. Their gene
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
2. Adult offspring of parents with PTSD have lower cortisol levels
3. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
4. Parents PTSD May Boost Stress in Offspring
5. Partnership for a Drug-Free America and Colorado Springs Police Department Introduce Methamphetamine Prevention Program to Colorado Law Enforcement
6. International Consulting Firm Health Fitness Dynamics Hired to Oversee Springbrook Inns Planned New Spa
7. COLORBLENDS to Donate Portion of Sales of Spring Forward Daffodil Blend to the Christopher and Dana Reeve Foundation
8. Springer adds Advances in Therapy to journals portfolio
9. Lifespring Health Promotes Health and Fitness by Sponsoring Silicon Valley Marathon on November 3rd and 4th
10. Announcing Always Best Care Senior Services Expansion into Colorado Springs, Colorado
11. Cold Spring Harbor scientists devise novel, low-cost method of sifting genomes high-value regions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... is available in French . ... surgical practice and regenerative medicine. A team led by ... (CNRS/ESPCI Paris Tech) and Didier Letourneur from the Laboratoire ... has just demonstrated that the principle of adhesion by ... to repair soft-tissue organs and tissues. This easy-to-use gluing ...
(Date:4/17/2014)... first genetic variant specifically associated with the risk ... 10-15 per cent of all breast cancer cases. ... cancer sub-type, called invasive lobular carcinoma, gives researchers ... particular kind of breast cancer, which can be ... (Thursday) in the journal PloS Genetics , ...
(Date:4/17/2014)... issue of Experimental Biology and Medicine ... Gaskins and Paul Kenis in the Institute of ... University of Illinois Urbana-Champaign describe their recent work ... a variety of cell functions including energy metabolism, ... roles in regulating normal cellular behavior, redox status ...
(Date:4/17/2014)... Jon McCullers, MD, was recently invited to submit ... Nature Reviews Microbiology , one of the world,s ... infectious disease specialist, and chair of the Department ... Science Center, analyzed the epidemiology and microbiology of ... as well as more recent 2009 novel H1N1 ...
(Date:4/17/2014)... estimated that as many as 10 million older Americans ... loneliness and isolation. , However, new research a ... older Americans for six years found that Internet ... depression by more than 30 percent. , "That,s a ... University professor of telecommunication, information studies and media who ...
Breaking Medicine News(10 mins):Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Internet use can help ward off depression among elderly 2
... By Kathleen Doheny HealthDay Reporter , ... soundtracks from a recording system worn by young children ... those children who may have autism or language delays, ... it possible to monitor development in a completely objective ...
... By Randy Dotinga HealthDay Reporter , MONDAY, July 19 ... levels of the chemicals known as PCBs in their bodies were ... found, but it,s not clear if the PCBs actually caused their ... indicate a serious health threat to those exposed to PCBs, which ...
... HealthDay Reporter , MONDAY, July 19 (HealthDay News) ... in every 50 heterosexual adults are now infected with HIV ... general population, U.S. health officials report. The finding ... the virus that causes AIDS, according to a team from ...
... (BC-CfE) published an important study today in the globally ... view that the benefits of highly active antiretroviral therapy ... preventing the transmission and spread of HIV. ... uses a combination of drugs to stop HIV from ...
... world what you are thinking or feeling. But it also ... according to research published in the July issue of ... Science. The new study reported on 40 people who ... this powerful nerve poison were used to deactivate muscles in ...
... the Centre for the AIDS Programme of Research in South ... positive findings from the CAPRISA 004 microbicide study, which marks ... HIV prevention as a whole. For years, antiretroviral medicines ... successful conduct of the CAPRISA 004 study, we now have ...
Cached Medicine News:Health News:Voice Recorders Seem to Help Detect Autism 2Health News:Could PCBs Help Boost Blood Pressure? 2Health News:Could PCBs Help Boost Blood Pressure? 3Health News:Poverty Driving HIV's Spread Among Urban Heterosexuals: Report 2Health News:Poverty Driving HIV's Spread Among Urban Heterosexuals: Report 3Health News:HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study 2Health News:HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study 3Health News:Can blocking a frown keep bad feelings at bay? 2Health News:Can blocking a frown keep bad feelings at bay? 3Health News:Anthony S. Fauci, M.D., on results from the CAPRISA 004 microbicide study 2
(Date:1/15/2014)... Most osteoporosis patients want a choice in the medication ... by Mission Pharmacal Company. The survey, conducted by ... community, revealed that 74 percent of osteoporosis patients surveyed ... other than a pill or a tablet. ...
(Date:1/15/2014)... GRAND RAPIDS, Mich. , Jan. 15, 2014 As ... of the flu virus, select Meijer pharmacies in ... and strep throat to eligible patients, enabling Meijer pharmacists to ... under strict protocol set by a physician participating in the ...
(Date:1/15/2014)...  Novation, the leading health care supply chain expertise, analytics ... (VAR) national contracts that expand its portfolio to provide ... costs. These include manufacturer product and service agreements, as ... ongoing IT consulting support. New Novation ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... Calif., April 13, 2011 Two new studies published ... and Related Diseases, a peer-reviewed journal, add to ... the LAP-BAND® Adjustable Gastric Banding System, made by Allergan, ... and effective weight-loss procedure. One study concluded that laparoscopic ...
... 13, 2011 / PRNewswire / -- ... today announced the Ion OneTouch System, an automated sample preparation system ... complexity, reduces hands-on time to five minutes and offers walk-away ... introductory price of under $5,000; the first shipments will be ...
Cached Medicine Technology:New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 2New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 3New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 4New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 5New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 6New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 7New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 8New Clinical Studies Reinforce the LAP-BAND® System is a Safe and Effective Weight-Loss Treatment for Obese Adults with Obesity-Related Comorbid Conditions 9Life Technologies Announces an Automated Sample Preparation System for its Ion PGM™ Sequencer 2Life Technologies Announces an Automated Sample Preparation System for its Ion PGM™ Sequencer 3Life Technologies Announces an Automated Sample Preparation System for its Ion PGM™ Sequencer 4
Peapod Rongeur, 5.5 length 140 mm....
It is designed for rigid skeletal fixation. These pins are constructed of stainless steel and can be removed for sterilization and reuse....
Mayfield Disposable Adult (plastic) Skull Pins are designed for rigid skeletal fixation....
... Karl Storz borescopes are rigid endoscopes for general ... lens system. The diameters of borescopes, i.e. rigid ... with viewing directions from 0 up to a ... zoom lens and wide angle view. Endoscopes with ...
Medicine Products: