Navigation Links
Cold Spring Harbor science teams identify 13 new tumor-suppressor genes in liver cancer
Date:11/18/2008

Over the years, hunting for cancer-related genes and understanding how they work has been an important, although time-consuming, exercise. At Cold Spring Harbor Laboratory (CSHL), five different research groups have now combined their expertise to speed up the rate of discovering cancer-related genes and validating their function in living animals.

The result of the collaborative effort is a large-scale, rapid, cost-effective genetic screen that in a preliminary test succeeded in uncovering 13 new tumor suppressors genes that inhibit the activity of cancer genes. Tumor suppressors are important in cancer development generally, and specifically in liver cancer, where they frequently have been found to be missing in people who develop the illness.

These discoveries, published online ahead of print on Nov.17 and scheduled to appear in the November 26 issue of Cell, "are a huge step forward in understanding the genetics of cancer and open up a host of new strategies to improve its diagnosis and treatment," according to CSHL Professor Scott W. Lowe, Ph.D., the corresponding author of the study. Other authors include Scott Powers, Ph.D., Director of the Human Cancer Genome Center at CSHL, and CSHL Professors Gregory J. Hannon, Ph.D., W. Richard McCombie, Ph.D., and Michael Wigler, Ph.D.

Pinpointing Tumor Suppressor Genes

Tumor suppressors are a crucial component of intracellular signaling networks that protect against uncontrolled cell proliferation. The benefits of such genes can be lost when DNA undergoes alterations, including mutations or deletions of entire stretches of chromosomes. A highly efficient genome-sequencing technique developed several years ago in the Wigler laboratory has made it possible to scan the genome of cancerous cells for, among other things, deleted portions of chromosomes where tumor suppressors are likely to reside.

Dr. Powers performed a genomic analysis of human liver can
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Canola Oil Consumed During Pregnancy Lowers Breast Cancer Risk for Offspring
2. Susan G. Komen for the Cure(R) Hosts Inaugural Illinois State Summit in Springfield
3. This Thanksgiving Season, Lifespring Health is Helping You Donate While You Shop
4. Springer launches Cognitive Computation
5. WellSpring Pharmaceutical Corp. Names Wendy Shusko as New Chief Operating Officer
6. Springer adds Journal of Neurodevelopmental Disorders to biomedical journal portfolio
7. WellSpring Pharmaceutical Corp. Acquires Consumer Product Brands from McNeil Consumer Healthcare -- Deal Enhances US and Canadian Pharmaceutical Business
8. The Health Insurance Advocate Radio Show Expands to Springfield, Missouri, and Reaches a New All-Time Ratings High for Female Listenership
9. Insomnia in parents can result in sleep problems, suicidal behavior among their offspring
10. HMS Holdings Corp. to Present at Stephens 2008 Spring Investment Conference
11. The Ensign Group to Present at the FBR Capital Markets 12th Annual Spring Investor Conference on May 29th
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... 2015 , ... Rhode Island Medical Imaging (RIMI) is pleased to announce the ... Wake Robin Road in Lincoln, RI. This satellite office will provide x-ray and ... out-patient x-ray hours in the state, which includes evenings and weekends. , “This ...
(Date:8/4/2015)... California (PRWEB) , ... August 04, 2015 , ... ... slides to Los Angeles commercial customers. Finding reliable hardware can be difficult ... liabilities. When putting an office together or designing a new facility, it ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... States, Richard Carmona, M.D., M.P.H., FACS, to its Board of Directors effective August ... save lives," Dr. Carmona said. "I strongly believe in the mission of the ...
(Date:8/4/2015)... ... 04, 2015 , ... Recent studies in the ... in binge drinking among certain populations and specific locations. Researchers, who ... examine trends and evidence to help facilitate health care treatment to meet current ...
(Date:8/4/2015)... ... August 04, 2015 , ... 24/7 Care At ... Angeles, Riverside, and San Bernardino, today announced that the U.S. Department of Veteran’s Affairs ... 24/7 Care At Home’s agency is well on the path to meeting the aspirational ...
Breaking Medicine News(10 mins):Health News:Rhode Island Medical Imaging Opens Satellite Imaging Center on Wake Robin Road in Lincoln 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 3Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 4Health News:Dr. Richard Carmona, 17th Surgeon General of the United States, Joins PerceptiMed, Inc.’s Board of Directors 2Health News:Dr. Richard Carmona, 17th Surgeon General of the United States, Joins PerceptiMed, Inc.’s Board of Directors 3Health News:DARA Responds To International Trends in Binge Drinking 2Health News:DARA Responds To International Trends in Binge Drinking 3Health News:24/7 Care At Home Receives Two Stars from the VA 2Health News:24/7 Care At Home Receives Two Stars from the VA 3
... Practice DirectorWESTFIELD, Ind., Feb. 10 maxIT Healthcare ... new division to provide technical and functional professional ... Healthcare, a leading professional services company for healthcare ... a presence in the health insurance market to ...
... de foie gras is discussed by Michael Greger of The ... forthcoming issue of the International Journal of Food Safety, ... as amyloid fibrils associated with damage to brain cells in ... can be present in the meat of poultry and mammals. ...
... launch a new national research centre to further understanding ... Centre, which will be opened by Sir William Stewart, ... 12 in the country to be funded by the ... the Government,s health research strategy. The joint venture has ...
... CHARLOTTE, N.C., Feb. 10 USHIFU, a worldwide ... invasive high intensity focused,ultrasound technologies, is pleased to ... consulting position of Chief Medical Officer. Dr.,Schoenberg is ... Urologic,Oncology who has authored more than 100 peer-reviewed ...
... 10 Erdman, A Cogdell Spencer,Company is pleased ... has earned the U.S. Environmental Protection Agency,s (EPA,s),prestigious ... efficiency,and environmental protection. America,s commercial buildings and industrial,plants ... similar facilities for energy,efficiency may qualify for the ...
... NUVA ), a medical device company focused ... the spine, announced today that Kevin O,Boyle, Executive Vice ... at the ROTH 21st Annual OC Growth Stock Conference ... Tuesday, February 17, 2009, at 11:30 a.m. PT.A live ...
Cached Medicine News:Health News:maxIT Healthcare Launches Healthcare Payer Professional Services Unit 2Health News:Give the foie gras a miss 2Health News:Biomedical research center opens in Liverpool 2Health News:USHIFU Appoints Mark Schoenberg, M.D. Chief Medical Officer 2Health News:Erdman, A Cogdell Spencer Company Earns the ENERGY STAR(R) for Superior Energy 2Health News:Erdman, A Cogdell Spencer Company Earns the ENERGY STAR(R) for Superior Energy 3Health News:Erdman, A Cogdell Spencer Company Earns the ENERGY STAR(R) for Superior Energy 4Health News:NuVasive to Present at ROTH 21st Annual OC Growth Stock Conference 2Health News:NuVasive to Present at ROTH 21st Annual OC Growth Stock Conference 3
(Date:8/4/2015)... Aug. 4, 2015 Young Innovations ("Young"), ... equipment, today announced the acquisition of the professional ... Inc. ("MPL PDCMD"). MPL PDCMD manufactures fluoride varnish, ... and restorative dental procedures. "This ... business in attractive, high-growth segments," said Dave ...
(Date:8/4/2015)... 2015  Sangamo BioSciences, Inc. (NASDAQ: SGMO ) ... Sangamo,s executive vice president, research and development, will provide ... ® development programs and an overview of the ... 11, 2015, at the 2015 Wedbush Pacgrow Healthcare Conference. ... York, NY . The presentation will ...
(Date:8/4/2015)... -- HeartWare International, Inc . (NASDAQ: HTWR ... support technologies that are revolutionizing the treatment of advanced ... Executive Officer, Doug Godshall , is scheduled to ... at 8:30 a.m. EDT on Thursday, August 13, 2015.  ... the InterContinental Boston. A live webcast of ...
Breaking Medicine Technology:Young Innovations Announces Acquisition of Medical Products Laboratories' Professional Dental Contract Manufacturing Division 2Sangamo BioSciences Announces Presentation At The 2015 Wedbush Pacgrow Healthcare Conference 2HeartWare Presentation At The Canaccord Genuity 35th Annual Growth Conference To Be Webcast 2
... Alarmist Messages Reflect Group,s Anti-Meat Bias, Stand,in Sharp ... Sense, WASHINGTON, Oct. 31 The American ... Fund,s (WCRF),recommendations to limit red and processed meat ... bias and should be met with,skepticism because they ...
... Oct. 30 Although Spanish-speaking cancer,patients are rapidly ... Internet, there are very few Spanish-language Web sites,available ... presented,October 28, 2007, at the American Society for ... Angeles. Spanish-speaking cancer patients were also shown ...
Cached Medicine Technology:American Meat Institute Calls WCRF Panel Recommendations on Meat Consumption Extreme and Unfounded 2American Meat Institute Calls WCRF Panel Recommendations on Meat Consumption Extreme and Unfounded 3American Meat Institute Calls WCRF Panel Recommendations on Meat Consumption Extreme and Unfounded 4Demand for Spanish-Language Cancer Web Materials Quadruples; Internet Resources and Access Remain Scarce 2
A simple solution to hand assisted laparoscopic surgery....
... The HandPort Systems non-adhesive ... during Hand-Assisted Laparoscopic Surgrery (HALS) ... touch, grasp, and palpate throughout. ... small as 6 cm, patients ...
... 200 series offers a range of ... The design delivers therapy to meet ... promote results in commercial and clinical ... differentiator in the SleepStyle 200 series ...
The SleepStyle 600 series with ThermoSmart delivers humidification with anti-rainout benefits. ThermoSmart technology offers a heated breathing tube that allows the constant delivery of optimal level...
Medicine Products: