Navigation Links
Cola and honey: Exploring food riddles in rhythm disturbances
Date:6/24/2013

Athens, Greece, 25 June 2013. Drinking excessive amounts of cola and eating honey made from the pollen of Rhododendrons can cause unusual syncope (fainting) and symptoms of arrhythmia, report two case studies presented as abstracts at the EHRA EUROPACE 2013 meeting, in Athens 23 to 26 June.

"Both these studies underline the importance of clinicians taking detailed medical histories for patients with unexplained arrhythmias and including questions about their dietary intakes," says Professor Andreas Goette, the EHRA Scientific Programme Committee chairperson.

In the first abstract Dr. Naima Zarqane and Prof. Nadir Saoudi, from the Princess Grace Hospital Centre, Monaco, report how excessive consumption of cola drinks can result in marked potassium loss (hypokalemia), QT prolongation on ECGs and potentially life threatening arrhythmias.

In the abstract the team describe the case of a 31 year old woman admitted to hospital for traumatic syncope. Once other problems had been excluded (including a family history of sudden death, digestive symptoms, and metabolic or hormonal abnormalities), tests revealed the patient had blood potassium levels of 2.4 mmol/L, and a QTc (The QT interval on the ECG corrected for heart rate) of 610 ms. Normal blood potassium levels range between 3.5 to 5.1 mmol/L; while the normal QTc for women is less than or equal to 450 ms.

When they took a medical history the clinicians discovered that since the age of 15 years the patient had exclusively replaced water with cola beverages. When cola consumption ceased on medical advice, the patient's potassium level returned to 4.1 mmol/L at one week, and 4.2 mmol/L at one month, and her QTc duration returned to 430 ms at one week.

A literature search revealed six other case studies where excessive cola consumption could be related to adverse medical conditions including rhabdomyolysis (damaged skeletal muscle tissue), arrhythmias, and even one death related to Torsades de pointes (a form of ventricular tachycardia that can degenerate into ventricular fibrillation).

There are two potential explanations for the connection between cola consumption and low blood potassium level the authors say. Through osmotic principles the high fructose corn syrup content of cola is likely to prevent water from being absorbed by the gut and lead to people suffering from diarrhoea that is associated with heavy fluid losses that 'flush' potassium out of the body. Additionally, caffeine in the cola is also likely to have an effect on the loop of Henle in the kidneys where it reduces the amount of potassium that is reabsorbed. In the heart reduced extracellular potassium can inhibit the potassium current in ion channels and delay ventricular repolarisation that may in turn promote arrhythmias.

"One of the take home messages is that cardiologists need to be aware of the connection between cola consumption and potassium loss and should ask patients found to have QT prolongation about beverage habits," says Dr. Zarqane.

"It's also important that the people are made aware of the potential health dangers of excessive consumption of sugary drinks. There are important political messages for governments to ensure that bottled water is cheaper than sugary drinks, which is not always the case," says Prof. Saoudi.

In a further study it would be helpful to explore whether there are differences in blood levels of potassium between people who had high cola intakes, and people who did not consume the drink, he says. Excessive drinking of cola and other sugary beverages is likely to have additional adverse cardiovascular effects. "Due to the high calorie intake it's likely to result in weight gain which increases the risk of developing metabolic syndrome," said Prof. Saoudi.

'Mad Honey Poisoning'

In the second abstract Dr. Ugur Turk, from Central Hospital, Izmir, Turkey, reports on the cases of a 68 year old father and 27 year old son who were both admitted to the Izmir emergency department at the same time with symptoms of vomiting and dizziness. Surface ECGs revealed both patients to have complete atrioventricular block and atrial flutter with slow ventricular responses.

When a history was taken both father and son reported that their breakfasts over the past three mornings had included high amounts of honey from the Black sea region of Turkey. This information immediately triggered Turk and colleagues to consider that their patients could be suffering from 'mad honey poisoning'.

Mad honey poisoning occurs after people consume honey contaminated with grayanotoxin, a chemical contained in nectar from the Rhododendron species ponticum and luteum. Grayanotoxin is a neurotoxin that binds to the sodium channels in the cell membrane, maintaining them in an open state and prolonging depolarisation.

"It's like the effect of cholingeric agents, and results in stimulation of the unmyelinated afferent cardiac branches of the vagus nerve which leads to a tonic inhibition of central vasomotor centres with a reduced sympathetic output and a reduced peripheral vascular resistance,"says Dr. Turk, "This in turn triggers the cardioinhibitory Berzold-Jarisch reflex which leads to bradycardia, continued hypotension, and peripheral vasodilatation."

Mad honey poisoning generally lasts no more than 24 hours, with symptoms of the mild form including dizziness, weakness, nausea, vomiting, excessive perspiration, hypersalivation and paraesthesia. Symptoms of the more severe form include syncope, seizures, complete atrioventricular block and even fatal tachyarrhythmias (due to oscillatory after potentials).

While no specific antidote exists for grayanotoxin poisoning mild cases can be treated with atropine and selective M2 muscarinic receptor antagonists; while for the more severe form treatment options include temporary pacemaker implantation, and vasopressor agents.

The possibility of honey poisoning, says Dr. Turk, should always be considered in previously healthy patients admitted with unexplained hypotension, bradycardia and other rhythm disturbances. The condition occurs most frequently in people who have consumed honey from the Black sea region of Turkey, a major bee keeping area that is also the native habitat of Rhododendron ponticum and luteum.

"The dissemination of honey around the world means that physicians any where may be faced with honey poisoning," says Dr. Turk. Anyone buying honey from Turkey should first consume a small amount and leave it a few days before eating any more to check that they do not experience strange side effects.

The symptoms of both father and son resolved without the need for any medications and they were discharged from hospital on the fourth day. When their honey was sent away for melissopalynology, (analysis of the pollen contained in honey) the result revealed it did indeed contain pollen from the Rhododendron species.


'/>"/>

Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Impact with Martin Sheen Exploring Molecular Medicine in a New Report
2. Yeast Infection No More: Review Exploring Linda Allen's Holistic Yeast Infection Treatment Released
3. Registration Opens for the 2013 BioTechniques Virtual Symposium—Exploring the Modern Lab
4. revitaRUGS Will Be “Exploring Universal Design” as a Sponsor at the ASID Forum in New York City
5. Impact with Martin Sheen Exploring the Benefits of Electronic Medical Records in New Report
6. Impact with Martin Sheen Exploring Recycling Popularity in New Report
7. Exploring the link between traumatic brain injury and people who are homeless
8. Breakthroughs with Martin Sheen Exploring How Businesses Manage Online Images
9. Exploring exercise benefits for breast cancer patients
10. Cedars-Sinai Medical Center studies galaxy-exploring camera in the operating room
11. High Schoolers Can 'Smile' While Exploring Dental Careers at Summer Camp in Maine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... notified by the Accreditation Council for Graduate Medical Education (ACGME) that it has ... This is the first accreditation of three residency programs that Memorial is currently ...
(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded daily by environmental and ... with these stressors is to adopt a more healthful diet, but too many people ... a certified Holistic Nutritionist and the creator of the Newport Beach Cleanse and 14-Day ...
(Date:4/29/2016)... ... April 29, 2016 , ... The ... nation’s productivity, stability, even security. Most importantly, employees are the single most important ... are American workers so unhappy? , Just under half of American workers are ...
(Date:4/29/2016)... ... April 29, 2016 , ... The ... in repaying their loans, more information about their loan terms and accounts, and ... student loan debt, including federal and private loans, has reached $1.3 trillion, with ...
(Date:4/29/2016)... ... ... Coast Dental Fort Stewart is celebrating its grand opening with an open ... Mall at 112 Vilseck Road in Fort Stewart. There will be refreshments, giveaways, and ... the opportunity to meet general dentists Thomas Richards, DDS, and Josh Faulk, DMD, and ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...   Acsis , a leading provider of supply ... research and advisory firm IDC has named it a ... Pharmaceutical Track and Trace Software 2016 Vendor Assessment (doc ... of the capabilities and business strategies of 10 vendors ... Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/28/2016)... , April 28, 2016 ... development of innovative peptide and gene-based immunotherapeutics and vaccines for ... will be presenting at the 3rd Annual Growth Capital ... 5 th , 2016 at Caesars Palace in Las Vegas, Nevada.  ... am on Wednesday, May 4 th by Dr. ...
(Date:4/27/2016)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... second quarter ended March 26, 2016.  GAAP diluted ... and non-GAAP diluted EPS of $0.47 increased 14.6%.  ... reported basis, and 6.3% on a constant currency ... quarter, highlighted by 14.6% growth in non-GAAP EPS," ...
Breaking Medicine Technology: