Navigation Links
Cognitive Score Changes Over Time May Hint at Dementia

Study authors stress new method is a complement to current testing,,,,

TUESDAY, Aug. 19 (HealthDay News) -- Yearly changes in a person's performance on cognitive testing may be associated with dementia, new research suggests.

Using a newly developed model to assess the effect of variations in a person's score from year to year, researchers found that just a one point change in variability on cognitive test scores could indicate as much as a fourfold increase in the risk of developing dementia.

"Above and beyond the prediction made by performance on neuropsychological tests, if you take into account the degree to which the individual varies in their cognitive abilities, there's an independent risk of dementia," said study author Roee Holtzer, an assistant professor of psychology and neurology at the Albert Einstein College of Medicine at Yeshiva University in New York City.

Results of the study are published in the Aug. 20 issue of the Journal of the American Medical Association.

Holtzer was quick to point out that the newly developed variability model was a complement to currently used tests, and is not meant to replace them. Additionally, he said, the findings need to be replicated.

Currently, doctors use cognitive function and memory tests to diagnose dementia or mild cognitive impairment. But, these tests compare one person to the "norm" for their age and education level.

Holtzer and his colleagues theorized that changes within an individual's score over time might be an additional tool for diagnosing dementia.

To that end, they developed a model to assess "within-person" variability on commonly used neuropsychological tests that compensated for sex, education, medical illness, and performance on each individual test. The model was then used to evaluate 897 people older than 70 between October 1993 and December 2007. Baseline testing was done, and then the participants had follow-up exams every 12 to 18 months.

During the follow-up, 61 cases of dementia were identified. Twenty-six of these people had scores in the highest quartile of the within-person variability index.

The researchers found that when they controlled for sex, education and medical illness, each one-point difference in the variability scores increased the risk of dementia by nearly four times. If they also factored in adjustments for scores on individual tests, the risk was still more than doubled for each one point difference in the variability model.

"The investigators found that relatively brief measures of memory and executive function reassessed annually would allow physicians to predict of dementia before the patient scores in the clearly impaired range," said Dr. Gary Kennedy, director of the division of geriatric psychiatry at Montefiore Medical Center in New York City.

"This study brings us one step closer to a simple, safe and reliable test of dementia risk," added Kennedy. And, that's important, he said, because once medications are developed to treat dementia, you have to be able to correctly identify who needs the treatment.

More information

To read more about diagnosing dementia, visit the Family Caregiver Alliance.

SOURCES: Roee Holtzer, Ph.D., assistant professor, psychology and neurology, Albert Einstein College of Medicine, Yeshiva University, New York City; Gary Kennedy, M.D., director, geriatric psychiatry, Montefiore Medical Center, New York City; Aug. 20, 2008, Journal of the American Medical Association

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Lack of sleep among new school-goers leads to behavioral, cognitive problems
2. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
3. Cognitive Activities Protect Against Alzheimers -- Social and Physical Activities Not Enough
4. Potential new approach to treat cognitive impairments in schizophrenia
5. Cognitive deficits lead to loss of self among cancer patients
6. Research links diet to cognitive decline and dementia
7. First Cognitive Training to Demonstrate Immediate Generalizability Through Standardized Assessments of Memory
8. New research on aging and cognitive training presented at GSAs Annual Meeting
9. Hypertension Linked to Risk of Mild Cognitive Impairment
10. Rhode Island Hospital to study driving ability of cognitively impaired elders
11. Older surgical patients at greater risk for developing cognitive problems
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... According to Los Angeles bariatric surgeon ... are not necessarily caused by real hunger, but instead by a hormone called ... notes that, while many patients are aware that weight loss surgery can help patients ...
(Date:11/30/2015)... ... November 30, 2015 , ... RoamRight, a leading provider of ... Public Television’s Travel With Kids to promote family vacations around the world. ... they explore international destinations and educate families about the people and places of the ...
(Date:11/30/2015)... ... 2015 , ... At Grand Dental PC, their priority is to deliver quality ... dental problems, you need to turn to a dentist who listens and responds; an ... a friendly dentist who counsels you on the best ways to maintain and improve ...
(Date:11/30/2015)... ... 30, 2015 , ... Newly reviewed and approved “NJ Top ... He has both advanced training and considerable experience in reconstructive dentistry with ... in cosmetic dentistry. He is an active Spear Education member providing full ...
(Date:11/30/2015)... ... November 30, 2015 , ... ”Dying Words: The AIDS Reporting of Jeff Schmalz ... 2015, to coincide with World AIDS Day. The multi-media project will be in audio ... epidemic as he was dying of the disease. , A collaborative effort led by ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... November 30, 2015 global cell culture market ... bn to US$11.3 bn by 2022 at a CAGR of 7.1% ... to grow from its 2013 value of US$6.1 bn to US$11.3 ... Transparency Market Research has announced the release of a new ... the report, titled ,Cell Culture Market - Global Industry Analysis, Size, ...
(Date:11/30/2015)...   Royal Philips (NYSE: PHG ... MRI guided user interface and automatic scan parameter selection ... Conditional implants, such as knee and hip replacements, spine ... of North America Annual Meeting (RSNA) . The new ... of this growing patient population. ScanWise Implant adds to ...
(Date:11/30/2015)... RATON, Fla. , Nov. 30, 2015   ... (the Institute) announced today that it has finalized ... device start-up company with technology developed at Florida State ... publicly-funded research, and bridges early funding gaps for companies ... and research institutions. --> ...
Breaking Medicine Technology: