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Cognition Pharmaceuticals Announces Positive Memory Results for Phase II Trial of C105 in Multiple Sclerosis
Date:12/17/2008

ities Test and the Subject's Global Assessment), the significant memory findings coupled with an encouraging safety profile clearly define the drug's effects and differentiate it from d-amphetamine in clinically meaningful ways, Cognition Pharmaceuticals said. Continued analyses of study data in several domains is in process.

"We are extremely encouraged by very strong findings in the areas of verbal and visual memory and learning from our trial. These memory results are consistent with and fit well with our understanding of the mechanism of action of C105 as documented in a range of preclinical and clinical studies," according to Cognition Pharmaceuticals President and Chief Scientific Officer David Erlanger, Ph.D.

The potential for C105 to help human memory was first identified by a team of researchers led by Mark Bear, Ph.D., currently Director of the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology. "In animals, we discovered that C105 can modulate memory consolidation -- a biochemical process by which temporary or labile changes in synaptic function are made enduring. We believe that C105 augments the function of modulatory systems in the brain that normally control memory strength. It is very exciting to see that this insight may be of therapeutic significance in humans with memory disorders."

Analyses of the full dataset from the trial are ongoing, with Drs. Ralph Benedict and Frederick Munschauer of the Jacobs Neurological Institute in Buffalo, New York serving as Co-Principal Investigators. A series of discussions with leading medical experts and publication of more detailed results over the coming months are under way.

About the Study

The Phase 2 trial was conducted by Cognition Pharmaceuticals, which described it as a randomized, double-blind, placebo-controlled, dose-titration study. A total of 151 su
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SOURCE Cognition Pharmaceuticals LLC
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