Navigation Links
Cogent trial shows lack of adverse interaction between clopidogrel and stomach medicine
Date:9/24/2009

SAN FRANCISCO, CA SEPTEMER 24, 2009 Results from a late breaking clinical trial called COGENT demonstrate that the combination of giving patients clopidogrel, a blood thinner commonly prescribed to patients with cardiovascular disease, and stomach medicines such as omeprazole, known as proton pump inhibitors (PPIs), did not lead to adverse events, as some prior studies had suggested. The results were presented at the 21st annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF).

COGENT is the first randomized assessment of administering clopidogrel and PPIs, which reduce the production of gastric acid, on clinical events. The trial involved 3,627 patients at 393 sites. Follow up was limited due to early termination of the trial.

Internal bleeding is a common adverse effect of antiplatelet or blood thinner therapies, such as clopidogrel. The gastrointestinal tract is the most common location for this type of bleeding, which often occurs in the form of peptic ulcer disease. The purpose of the trial was to determine whether the administration of clopidogrel and omeprazole is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer disease in the setting of concomitant aspirin therapy.

The primary endpoint of the trial was a composite of upper gastrointestinal clinical events, including gastroduodenal bleeding, symptomatic gastroduodenal ulcer, and persistent pain with multiple gastric erosions, obstruction or perforation.

There was a significant reduction in gastrointestinal events with PPI use. This had not been previously demonstrated in patients receiving aspirin and clopidogrel.

"Further research is needed to define the optimal strategy to reduce GI events in patients on antithrombotic therapy, though prophylactic PPI use seems promising," said lead investigator, Deepak L. Bhatt, MD, MPH, Chief of
'/>"/>

Contact: Judy Romero
jromero@crf.org
347-407-2774
Cardiovascular Research Foundation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cogentus Pharmaceuticals Completes $62.5 Million Private Financing
2. Cogentus Pharmaceuticals Names Scientific Steering Committee for Global Phase 3 Clinical Program
3. Varian Medical Systems Teams With Cogent Health Solutions to Offer Case Management Software for Cancer Survivorship
4. New Heart Pump Shows Promise in Trial
5. Trial to Test Gene Therapy for Angina in Women
6. AKELA Pharma Inc. announces positive results for the extension part of its Phase IIb Fentanyl TAIFUN(R) trial
7. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
8. Provectus Pharmaceuticals, Inc. Begins Phase 2 Clinical Trial for Metastatic Melanoma
9. MDS Pharma Services Wins Award for Management of Global Malaria Trial
10. New Ovarian Cancer Drug Trial Under Way
11. Study Questions Dead-End Cancer Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Dawn Echols’ professional background spans success in multiple ... has honed her people skills and led her ... ( http://dawningphoenix.com ) work includes private practice, EAP, ... violence. , As owner and executive director ... and groups for a variety of disorders. Dawn ...
(Date:7/28/2014)... Ticket Down is reliable source ... Dallas, TX at the Cotton Bowl. The 2014 Guinness ... and it is an eight team tourney. The tournament ... teams from La Liga, Serie A, English Premier League, and ... out on the pitch include: Manchester United, Manchester City, ...
(Date:7/28/2014)... Braintree, Massachusetts (PRWEB) July 28, 2014 ... the Summit Provider Exchange technology solution ... office integration efforts and support collaboration with their ... 242 bed acute-care medical center located in New ... 800,000 seasonal visitors with a variety of inpatient ...
(Date:7/28/2014)... July 28, 2014 (HealthDay News) -- British researchers report ... far fewer germs around. In their experiments, the ... more germs from one person to the other than ... the more casual exchange might suffice as a cultural ... findings are published in the August issue of the ...
(Date:7/28/2014)... Washington, DC (PRWEB) July 28, 2014 ... recipe app for iOS, App is available on iTunes for ... first of its kind, Audio Chef allows you to listen ... gourmet cuisine the easy way: simply get out the ingredients ... no need to measure or prepare ingredients ahead of time, ...
Breaking Medicine News(10 mins):Health News:Dawn M. Echols, M.S., LPC of Dawning Phoenix Speaks at Newly Formed Task Force 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 3Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 2Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 3Health News:'Fist Bump' May Beat Handshake for Cleanliness 2Health News:'Fist Bump' May Beat Handshake for Cleanliness 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 4
... , , DENVER, Aug. 25 ... the life of a beloved pet--yours or someone else,s. Morris Animal Foundation,s (MAF) ... animal lovers an opportunity to improve the future of animal health. ... names of the pet owner and the pet and include a built-in frame ...
... for a non-invasive diagnostic test , TUESDAY, Aug. 25 (HealthDay ... oral cancer, researchers have found that saliva contains at least ... U.S. researchers measured microRNA levels in the saliva of 50 ... They identified at least 50 microRNAs that may be associated ...
... , WASHINGTON, Aug. 25 Covenant ... States $4.5 million to resolve allegations that it violated the False ... , This settlement resolves allegations that Covenant submitted false ... violated the Stark Law. The Stark Law prohibits a hospital ...
... , IRVINE, Calif., Aug. 25 Masimo ... and Measure-Through Motion and Low-Perfusion pulse oximetry, announced today that ... Report as one of ,America,s Best Children,s Hospitals, has completed ... , , Masimo SET has been clinically ...
... , Clearinghouse Served Hundreds of Community-Based Health Organizations ... A casualty of California Governor Arnold Schwarzenegger,s draconian cuts in ... The L.A. Gay & Lesbian Center, which operated the program ... of AIDS that all funding for it had been eliminated. , ...
... 2009) The Henry M. Jackson Foundation for the ... Uniformed Services University of the Health Sciences doctoral students ... program, established in 1988, is comprised of two Henry ... Each fellow receives a stipend and travel support. ...
Cached Medicine News:Health News:Honor Spirit and Memory of a Special Pet During National Pet Memorial Month 2Health News:Saliva May Help Spot Oral Cancer Early 2Health News:Update: Covenant Medical Center to Pay U.S. $4.5 Million to Resolve False Claims Act Allegations 2Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 2Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 3Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 4Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 5Health News:Schwarzenegger's Budget Cuts Force Closure of California AIDS Clearinghouse 2Health News:Henry M. Jackson Foundation names fellowship award winners 2
(Date:7/28/2014)... , July 28, 2014 Reportbuyer.com has ... Global Bone Densitometers Market 2014-2018 ... bone densitometry scan is a special type of X-ray ... bone. It is used primarily to detect osteopenia or ... and the risk of fractures is high. The purpose ...
(Date:7/28/2014)... July 28, 2014 /PRNewswire-iReach/ -- June 28 th , 2014 ... has developed the AMAS cancer test, is making its AACC ... date, the test, which is a serum-based in vitro immunoassay, ... as a significant tool in the fight against cancer recurrence. ... With an estimated 17 million cancer survivors in the US ...
(Date:7/28/2014)...  Surgical Theater, LLC announced today the addition ... Board. New members include Ori J. Braun ... and New Technologies for Given Imaging Ltd., and ... President and General Manager of Philips Healthcare,s Computer ... technology to brain surgery and has developed software-based ...
Breaking Medicine Technology:Global Bone Densitometers Market 2014-2018 2Global Bone Densitometers Market 2014-2018 3Global Bone Densitometers Market 2014-2018 4Global Bone Densitometers Market 2014-2018 5Oncolab, Inc. Exhibits Pioneering AMAS Cancer Test at AACC 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5
... Companies to Lead Public and Investor Relations Efforts -- BEIJING, Sept. 8 /PRNewswire-Asia-FirstCall/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by ...
... FALLS, Idaho, Sept. 8 International Isotopes Inc. (OTC ... an agreement with URENCO USA to provide assistance to ... State of New Mexico permitting processes. INIS ... Commission (NRC) in December 2009 for the construction of ...
Cached Medicine Technology:Lotus Pharmaceuticals Announces Engagement of RedChip Companies to Lead Public and Investor Relations Efforts 2Lotus Pharmaceuticals Announces Engagement of RedChip Companies to Lead Public and Investor Relations Efforts 3Lotus Pharmaceuticals Announces Engagement of RedChip Companies to Lead Public and Investor Relations Efforts 4Lotus Pharmaceuticals Announces Engagement of RedChip Companies to Lead Public and Investor Relations Efforts 5Lotus Pharmaceuticals Announces Engagement of RedChip Companies to Lead Public and Investor Relations Efforts 6Lotus Pharmaceuticals Announces Engagement of RedChip Companies to Lead Public and Investor Relations Efforts 7Lotus Pharmaceuticals Announces Engagement of RedChip Companies to Lead Public and Investor Relations Efforts 8International Isotopes Inc. Announces Completion of a Licensing and Permitting Assistance Agreement with URENCO USA 2International Isotopes Inc. Announces Completion of a Licensing and Permitting Assistance Agreement with URENCO USA 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: