Navigation Links
Codeine Risky for Kids After Certain Surgeries, FDA Says

THURSDAY, Feb. 21 (HealthDay News) -- Children who are given codeine for pain relief after surgery to remove tonsils or adenoids are at risk for overdose and death, U.S. health officials said Thursday.

The U.S. Food and Drug Administration said a new boxed warning -- the agency's strongest caution -- will be added to the labels of codeine-containing products to warn about this danger.

The FDA strongly recommends against the use of codeine to manage pain in children after surgery to remove tonsils or adenoids, and suggests that doctors use an alternate pain reliever. The agency also said parents and caregivers need to be aware of the risks and ask for a different pain medicine if their children are prescribed codeine after having their tonsils or adenoids removed.

Codeine is an opioid (narcotic) medication used to treat mild to moderate pain and is often prescribed to children after tonsil or adenoid removal. However, some children have died after being given codeine within the recommended dose range.

In August 2012, the FDA warned about the danger in children who are "ultra-rapid metabolizers" of codeine, which means their liver converts codeine to morphine in higher-than-normal amounts. High levels of morphine can result in potentially fatal breathing problems.

Since then, a safety review by the FDA identified 10 deaths and three overdoses associated with codeine that occurred among children in the United States between 1969 and May 2012. Many of these children were recovering from surgery to remove tonsils or adenoids.

All of the children, aged 21 months to 9 years old, received doses of codeine within the normal dose range. Signs of morphine overdose developed within one to two days after the children began taking codeine, the FDA said in an agency news release.

Codeine is available by prescription either alone or in combination with acetaminophen and aspirin, and in some cough and cold medications.

When prescribed to treat pain, codeine should not be given on a fixed schedule, but only when a child needs relief from pain. They should never receive more than six doses in a day, the FDA said.

Children receiving codeine for pain should be closely monitored for signs of morphine overdose. These include: unusual sleepiness, such as being difficult to wake up; confusion or disorientation; breathing problems; and blueness on the lips or around the mouth.

Parents and caregivers who notice such signs should stop giving codeine and immediately take the child to an emergency department or call 911, said Dr. Bob Rappaport, director of the division of anesthesia, analgesia and addiction products in FDA's Center for Drug Evaluation and Research.

More information

The U.S. National Library of Medicine has more about codeine.

-- Robert Preidt

SOURCE: U.S. Food and Drug Administration, news release, Feb. 21, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Codeine After Surgery Could Endanger Certain Kids: Study
2. Three Kids Dead From Codeine After Surgery: FDA
3. Are women with a history of violent experiences more likely to have risky sex?
4. Women Exposed to Violence Might Have More Risky Sex
5. Indoor Tanners Rationalize Risky Behavior, Study Finds
6. Identifying risky behaviors: The key to HIV prevention
7. Study links alcohol/energy drink mixes with casual, risky sex
8. Year of Taking Risky Blood Thinners May Be Unnecessary After Stent Surgery
9. Common Antidepressants Too Risky During Pregnancy, Researchers Say
10. 2-Year Period After Parents Suicide Try Most Risky for Children: Study
11. Fraudulent Data May Have Led to Use of Risky Treatment in ICUs
Post Your Comments:
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
Breaking Medicine Technology: