Navigation Links
Codeine After Surgery Could Endanger Certain Kids: Study
Date:4/11/2012

By Alan Mozes
HealthDay Reporter

WEDNESDAY, April 11 (HealthDay News) -- Concerns about codeine safety have gained traction in the wake of the postoperative experience of four children who all carried a rare genetic mutation. A new study describes what happened to three of the patients, while a similar case came to light in 2009.

In certain very rare genetic cases, the common painkiller codeine can be lethal. The gene mutation causes the body to metabolize codeine into morphine at levels 50 percent to 70 percent higher than normal. Among such patients, an otherwise standard amount of codeine can unpredictably turn into a toxic overdose.

After undergoing tonsillectomies for sleep apnea, three children with the gene mutation ultimately died, while the fourth patient barely survived.

"Codeine has been around for the better part of a century as a medication, including as a syrup for children," said study lead author Dr. Gideon Koren, a professor of pediatrics, pharmacology, pharmacy and medical genetics at the University of Toronto. "That's the drug that is used by most surgeons in the U.S. to control pain. But codeine is not actually the analgesic. To deal with pain it has to be transformed in the liver into morphine. And that happens with everyone who takes it to some degree," he explained.

"Most people take 10 molecules of codeine and make one molecule of morphine," added Koren, who is also a professor at the University of Western Ontario. "The problem is that our knowledge of genetics has revealed that there are people who are ultra-rapid metabolizers. They take 10 molecules of codeine and make two, three or even five molecules of morphine. In other words, they take the right doses but end up poisoning themselves."

Koren and his colleagues described the cases of the three recent pediatric codeine overmetabolizers in the April 9 online and May print issue of Pediatrics. The earlier case was re
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. Mothers postpartum oxycodone use: No safer for breastfed infants than codeine
2. Breast cancer patients suffer treatment-related side effects long after completing care
3. Experts Offer Advice After Yankee Pitchers Trampoline Injury
4. Young girls more likely to report side effects after HPV vaccine
5. Moderate Drinking Might Help Men Live Longer After Heart Attack
6. Middle school boys who are reluctant readers value reading more after using e-readers
7. 1 in 5 Pharmacies Hinders Teens Access to Morning-After Pill: Study
8. Radiotherapy for DCIS still protects against recurrence after 15 years
9. Corner Stores Stock Healthier Foods After Aid Program Changes
10. ICU May Not Be Needed After Sleep Apnea Surgery
11. Drug Seems to Speed Recovery After Traumatic Brain Injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Codeine After Surgery Could Endanger Certain Kids: Study
(Date:5/24/2013)... Tampa, FL (PRWEB) May 24, 2013 Compromise ... wants to compromise when it comes to sleep and comfort. ... sleep preferences prove highly individual. For some, this can cause ... Bed, a mattress advice blog, tackles eight common issues in ... “ She Wants Soft, He Wants Firm: What to do ...
(Date:5/24/2013)... 2013 Range Kleen Mfg. strives to “TCOTC.” ... Customer, from the President's desk to the Shipping Dock.” We ... integrity, and having passion while creating excellence and quality being ... company to do the right thing and what better way ... affected by devastation. , Throughout the year Range Kleen donates ...
(Date:5/24/2013)... Park City, Utah (PRWEB) May 24, 2013 ... new information on the Indiana Health Insurance ... flexible alternatives to traditional employer sponsored health benefits, ... and health reimbursement arrangements . , ... as part of the Affordable Care Act (ACA), ...
(Date:5/24/2013)... Before you start the grill, before you watch the game, kick ... Hoda Kotb on the Today Show on Memorial Day. Carley ... Lee and Hoda, including the new LawnBott® LB75 robotic mower. ... the military who made the ultimate sacrifice for us. On ... and family and enjoy the day. With a LawnBott® robotic ...
(Date:5/24/2013)... This week is National EMS Week, ... to provide the best emergency care and to improve ... is also to educate the public that all can ... are the first link, and a very important one. ... after a cardiac arrest can triple a victim’s chance ...
Breaking Medicine News(10 mins):Health News:What’s The Best Bed Offers Mattress & Sleep Solutions for Opposite Couples 2Health News:Range Kleen Partners with Berndes in Red Cross Promotion: Taking Care of Oklahoma 2Health News:Zane Benefits Publishes New Information on the Indiana Health Insurance Exchange 2Health News:Zane Benefits Publishes New Information on the Indiana Health Insurance Exchange 3Health News:Zane Benefits Publishes New Information on the Indiana Health Insurance Exchange 4Health News:LawnBott® Visits the Today Show with Kathie Lee and Hoda 2Health News:Acadian Medics Reunite with Miracle Baby 2
... be made quickly, researchers say , , WEDNESDAY, June 11 ... whole-virus bird flu vaccine that appears to be safe, ... use and also able to be manufactured much more ... antibodies against the virus after receiving a second dose ...
... out as source of contaminated tomatoes, they add , , ... said Wednesday they are zeroing in on a source ... , "The question is where specifically did these tomatoes ... at the U.S. Food and Drug Administration said during ...
... of Medicine and Penn State Hershey College of Medicine ... the cornea. Published in the June issue of the ... and Dr. Mark Kester identified a novel ceramide, a ... corneal haze, corneal thickening and inflammation. These nano-sized packages ...
... June 11th 2008: At least 50% of recent onset ... signs and symptoms) within 36 weeks when following a ... tight control, according to results of a study presented ... European League Against Rheumatism in Paris, France. Results of ...
... affect changes, study says , , WEDNESDAY, June 11 (HealthDay News) ... the bowel more susceptible to cancer by making the cells ... new study suggests. , Scientists at the Institute of Food ... the British Journal of Cancer , are now looking ...
... Products Are Not a Potential Salmonella Risk, ... warned about consuming certain raw tomatoes due to ... emphasized today that heat-processed tomato products,-- such as ... a safe choice,for consumers to continue enjoy. In ...
Cached Medicine News:Health News:New Bird Flu Vaccine Shows Promise 2Health News:New Bird Flu Vaccine Shows Promise 3Health News:New Bird Flu Vaccine Shows Promise 4Health News:U.S. Health Officials Closer to Origin of Salmonella Outbreak 2Health News:U.S. Health Officials Closer to Origin of Salmonella Outbreak 3Health News:U.S. Health Officials Closer to Origin of Salmonella Outbreak 4Health News:50 percent of recent onset RA patients become free of signs and symptoms within 36 weeks 2Health News:DNA Coding May Make Bowel Prone to Cancer 2Health News:Clarity Needed Amidst Tomato Contamination Confusion 2
(Date:5/24/2013)... CHAPEL HILL, N.C. , May 24, 2013 ... Affairs to the forefront of many organizations, priority ... biopharmaceutical and medical device sectors understand a strong ... meeting current challenges in clinical development, market ... operate effectively to create a vital bridge between ...
(Date:5/24/2013)... 2013  BD (Becton, Dickinson and Company) (NYSE: ... that it will present at the Deutsche Bank 38 th ... at 10:40 a.m. (ET). A live webcast ... website at www.bd.com/investors and will be available for ... BD BD is a leading global medical technology ...
(Date:5/24/2013)... May 24, 2013 /PRNewswire-iReach/ -- Phoenix Houses of ... abuse services organization, is hosting its tenth annual "Triumph ... on June 6, 2013.  More than 300 people are ... the adolescent residential treatment centers, family therapy, and prevention ... whose accomplishments have positive influences on the health and welfare ...
Breaking Medicine Technology:Building Medical Affairs Capabilities to Ensure Organizational Success across Key Operational Areas 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 3
... At Heart Rhythm 2011, the Heart Rhythm Society,s 32nd annual ... (NYSE: PHG, AEX: PHI) and the Heart Rhythm Society (HRS) ... that shape the diagnosis and minimally invasive treatment of heart ... by disturbed electrical signals that regulate the heart and can ...
... Tulsa Shock guard Andrea Riley and Basketball Hall of Famer ... for Adolescent Health and Medicine (SAHM) today to bring ... for Teens is a national awareness campaign designed to ... against serious and potentially life-threatening diseases. To ...
Cached Medicine Technology:Philips and the Heart Rhythm Society Collaborate to Showcase the Electrophysiology (EP) Lab of Today and the Future 2Philips and the Heart Rhythm Society Collaborate to Showcase the Electrophysiology (EP) Lab of Today and the Future 3Tulsa Shock Guard Andrea Riley and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 2Tulsa Shock Guard Andrea Riley and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 3Tulsa Shock Guard Andrea Riley and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 4Tulsa Shock Guard Andrea Riley and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 5
... safely, the Hoefer GD 2000 uses a dry-heat ... the gel through a heavy aluminum platen. , ... 33 x 44 cm in as little as ... heat distribution and even vacuum distribution under the ...
This double-up gel dryer system, 200-240 V, includes 2 Model 583 gel dryers, HydroTech™ vacuum pump, and double-up rack....
... The GelAir™ drying system utilizes a hot air ... are dried on a clear cellophane support for ... provide a smooth, flat assembly surface for the ... drying frames at once. This 115 V, 60 ...
The GelAir™ dryer is a component of the GelAir drying system. Supplied as a 115 V, 60 Hz gel drying oven....
Medicine Products: