Navigation Links
Codeine After Surgery Could Endanger Certain Kids: Study
Date:4/11/2012

By Alan Mozes
HealthDay Reporter

WEDNESDAY, April 11 (HealthDay News) -- Concerns about codeine safety have gained traction in the wake of the postoperative experience of four children who all carried a rare genetic mutation. A new study describes what happened to three of the patients, while a similar case came to light in 2009.

In certain very rare genetic cases, the common painkiller codeine can be lethal. The gene mutation causes the body to metabolize codeine into morphine at levels 50 percent to 70 percent higher than normal. Among such patients, an otherwise standard amount of codeine can unpredictably turn into a toxic overdose.

After undergoing tonsillectomies for sleep apnea, three children with the gene mutation ultimately died, while the fourth patient barely survived.

"Codeine has been around for the better part of a century as a medication, including as a syrup for children," said study lead author Dr. Gideon Koren, a professor of pediatrics, pharmacology, pharmacy and medical genetics at the University of Toronto. "That's the drug that is used by most surgeons in the U.S. to control pain. But codeine is not actually the analgesic. To deal with pain it has to be transformed in the liver into morphine. And that happens with everyone who takes it to some degree," he explained.

"Most people take 10 molecules of codeine and make one molecule of morphine," added Koren, who is also a professor at the University of Western Ontario. "The problem is that our knowledge of genetics has revealed that there are people who are ultra-rapid metabolizers. They take 10 molecules of codeine and make two, three or even five molecules of morphine. In other words, they take the right doses but end up poisoning themselves."

Koren and his colleagues described the cases of the three recent pediatric codeine overmetabolizers in the April 9 online and May print issue of Pediatrics. The earlier case was re
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Mothers postpartum oxycodone use: No safer for breastfed infants than codeine
2. Breast cancer patients suffer treatment-related side effects long after completing care
3. Experts Offer Advice After Yankee Pitchers Trampoline Injury
4. Young girls more likely to report side effects after HPV vaccine
5. Moderate Drinking Might Help Men Live Longer After Heart Attack
6. Middle school boys who are reluctant readers value reading more after using e-readers
7. 1 in 5 Pharmacies Hinders Teens Access to Morning-After Pill: Study
8. Radiotherapy for DCIS still protects against recurrence after 15 years
9. Corner Stores Stock Healthier Foods After Aid Program Changes
10. ICU May Not Be Needed After Sleep Apnea Surgery
11. Drug Seems to Speed Recovery After Traumatic Brain Injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Codeine After Surgery Could Endanger Certain Kids: Study
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... anti-HIV therapies, doctors still have not been able to eradicate ... largely because of the persistence of HIV in hideouts known ... HIV causes much of its damage due to the large ... known as CD4+ T cells, are largely contained in lymph ...
... Ad For Containing,Inappropriate, Content While Original PP:GG Content ... "It is outrageous that,YouTube would black-out our video ... while it continues to carry the original Planned,Parenthood ... Life League., The "inappropriate nature" cited by ...
... DaVita Inc.,(NYSE: DVA ) today announced results for ... for the three months ended December 31, 2007 was ... million, or $0.70 per,share, for the same period of ... for the year ended December 31, 2007 excluding after-tax,gains ...
... Holdings, Inc. (Nasdaq: NHWK ), the leading provider of ... results for its fourth quarter and full year ended December ... grew 65% to $151.7 million from $92.2 million for ... million, or 23% year-over-year, while acquisitions ...
... 13 DaVita Inc.,(NYSE: DVA ), today announced ... Chief Financial Officer effective March, 1, 2008. Rich will ... expected to go on for 1 to,2 years., ... Officer, commented, "We are glad to have,Rich once again ...
... increase in depression, anxiety , , WEDNESDAY, Feb. 13 (HealthDay ... search of symptom relief are more likely to suffer ... , A slowing down in the ability to process ... is a rise in the rate of depression and ...
Cached Medicine News:Health News:HIV persists in the gut despite long-term HIV therapy 2Health News:ICYMI: YouTube Censors American Life League 2Health News:DaVita 4th Quarter 2007 Results 2Health News:DaVita 4th Quarter 2007 Results 3Health News:DaVita 4th Quarter 2007 Results 4Health News:DaVita 4th Quarter 2007 Results 5Health News:DaVita 4th Quarter 2007 Results 6Health News:DaVita 4th Quarter 2007 Results 7Health News:DaVita 4th Quarter 2007 Results 8Health News:DaVita 4th Quarter 2007 Results 9Health News:DaVita 4th Quarter 2007 Results 10Health News:DaVita 4th Quarter 2007 Results 11Health News:DaVita 4th Quarter 2007 Results 12Health News:DaVita 4th Quarter 2007 Results 13Health News:DaVita 4th Quarter 2007 Results 14Health News:DaVita 4th Quarter 2007 Results 15Health News:DaVita 4th Quarter 2007 Results 16Health News:DaVita 4th Quarter 2007 Results 17Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 2Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 3Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 4Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 5Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 6Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 7Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 8Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 9Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 10Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 11Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 12Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 13Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 14Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 15Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 16Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 17Health News:NightHawk Radiology Holdings, Inc. Announces Fourth Quarter and Full-Year 2007 Results; Updates 2008 Guidance 18
(Date:12/15/2014)... , Dec. 15, 2014   DaVita ... one of the nation,s largest and most innovative ... its business units, DaVita Clinical Research  (DCR) and  ... to further expand its extensive clinical research and ... kidney disease (CKD) and end-stage renal disease (ESRD), ...
(Date:12/14/2014)... 2014  ChartSpan, a consumer platform for patients managing ... iPad medical app in the United States ... ChartSpan is an iPhone and iPad ... and send electronic healthcare records. The product was built ... of waiting for the healthcare system to deliver on ...
(Date:12/13/2014)... 12, 2014  Radiologists can transmit their reports, ... their referring physicians, electronic health records (EHR) systems ... technology.  That was the message ... (ADS) at the recent Radiology Society of North ... radiology reports in this manner also helps referring ...
Breaking Medicine Technology:DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3
... Abaxis, Inc. (Nasdaq: ABAX ), a medical products ... Severson, chairman and chief executive officer, will present at the ... 2, 2009 at 2:00 p.m. ET. The conference will be ... City. , About Abaxis , Abaxis develops, ...
... , CHAPEL HILL, N.C., Nov. 25 ... chief executive officer, will present at the Piper Jaffray 21st ... 2009, at The New York Palace Hotel in New York ... company,s two leading antibiotic clinical programs for the treatment of ...
Cached Medicine Technology:
... Pulse Oximeters are high performance, easy-to-use ... proven signal processing to track even ... with Oxismart Advanced Signal Processing and ... identify electronic and optical noise, as ...
The Model 5340 is intended for continuous pulse oximetry and has visual and audible alarms to aid with patient monitoring....
The Model 340DT is a new desk top pulse oximeter that was designed for continuous pulse oximetry and has visual and audible alarms to aid with patient monitoring....
... The Model 130 has expanded memory capabilities ... has memory to retain oxygen saturation and pulse ... modes to best suit your needs:, ,1. ... minutes of information for a single patient, making ...
Medicine Products: