Navigation Links
Cocoa may enhance skeletal muscle function
Date:3/2/2012

A small clinical trial led by researchers at UC San Diego School of Medicine and VA San Diego Healthcare System (VASDHS) found that patients with advanced heart failure and type 2 diabetes showed improved mitochondrial structure after three months of treatment with epicatechin-enriched cocoa. Epicatechin is a flavonoid found in dark chocolate.

The results of this initial study has led to the implementation of larger, placebo-controlled clinical trial at UC San Diego School of Medicine and VASDHS to assess if patients with heart failure and diabetes show improvement in their exercise capacity when treated with epicatechin-rich cocoa.

The study published this week by the journal Clinical and Translational Science looked at five profoundly ill patients with major damage to skeletal muscle mitochondria. Mitochondria are structures responsible for most of the energy produced in cells. These "fuel cells" are dysfunctional as a result of both type 2 diabetes and heart failure, leading to abnormalities in skeletal muscle. In patients with heart failure and diabetes abnormalities in both the heart and skeletal muscle result in impaired functional capacity. These patients often complain of shortness of breath, lack of energy and have difficulty walking even short distances.

The trial participants consumed dark chocolate bars and a beverage with a total epicatechin content of approximately 100 mg per day for three months. Biopsies of skeletal muscle were conducted before and after treatment. After the three-month treatment, the researchers looked at changes in mitochondria volume and the abundance of cristae, which are internal compartments of mitochondria that are necessary for efficient function of the mitochondria, and measurable by electron microscopy.

"The cristae had been severely damaged and decreased in quantity in these patients," said one of the senior investigators, Francisco J. Villarreal, MD, PhD of UC San Diego's Department of Medicine's Division of Cardiology. "After three months, we saw recovery cristae numbers back toward normal levels, and increases in several molecular indicators involved in new mitochondria production."

The results, which mimicked earlier studies showing improvement in skeletal and heart muscle function in animal models after treatment with epicatechin, were promising enough to prompt the larger study.

The principal investigator of this trial was Pam R. Taub, MD, assistant professor of medicine at UC San Diego and the VA San Diego Healthcare System. Taub will be leading the new clinical trial at UC San Diego that will enroll normal sedentary subjects as well as patients with heart failure/diabetes who will be treated with placebo, or epicatechin-rich chocolate.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Cocoa could prevent intestinal pathologies such as colon cancer
2. Dietary Cocoa Flavanols Improve Vascular And Blood Pressure Measures For Coronary Artery Disease Patients
3. Summertime Decadence: Rodelle Cocoa Launches in Western Canada
4. World Cocoa Foundation Launches Cocoa Livelihoods Program in Nigeria
5. Chocolate Industry Leaders Sign Agreement, Align on Path Towards Increasing Consumer Availability & Consistency of Beneficial Cocoa Flavanols
6. Combination therapy may enhance gemcitabine activity
7. Nanoparticles may enhance cancer therapy
8. New tool enhances view of muscles
9. New research could lead to enhanced MRI scans
10. Does caffeine enhance exercise performance? The debate continues
11. Enhanced treatment of brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... 19, 2017 , ... Big Barker , a Philadelphia-based ... 2016 donation of dog beds to the K9 officers of the Allentown, Pennsylvania ... its contribution from city and state officials. , The U.S. House of ...
(Date:9/19/2017)... Montclair, NJ (PRWEB) , ... September 19, 2017 ... ... fall following the success of the annual PAINWeek National Conference. On October 7, ... will be an educational and exciting program providing busy clinicians and allied healthcare ...
(Date:9/19/2017)... ... 2017 , ... Bone Solutions Inc. (BSI), an orthobiologics technology ... device, OsteoCrete®. OsteoCrete® bone void filler is designed to assist with bone repair ... critical property for bone health and development. , “We’re excited to bring this ...
(Date:9/19/2017)... , ... September 19, 2017 , ... Premiere Long Island ... Sami, was recently named one of the best dentists in America under age 40 ... dental professionals nationwide. Every fall, the magazine features the best 40 dentists under the ...
(Date:9/19/2017)... ... September 19, 2017 , ... Inc. magazine ranked ... ranking of the nation's fastest-growing private companies. The list represents a unique look ... independent small and midsized businesses. Endo-Systems is a leading B2B distributor of today’s ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)...   OrthoAtlanta has been named the official orthopedic ... (AFHC) for the 2018 College Football Playoff (CFP) National Championship ... Stadium in Atlanta, Georgia . OrthoAtlanta is ... campaign, participating in many activities leading up to, and including ... ...
(Date:9/12/2017)... Sept. 12, 2017  ValGenesis Inc., the global ... is pleased to announce the appointment of Dr. ... its Board of Directors and Chairman of Advisory ... life science companies to manage their entire validation ... paper in this process. Furthermore, ValGenesis VLMS enables ...
(Date:9/9/2017)... 2017  Eli Lilly and Company (NYSE: ... data for lasmiditan, an investigational, oral, first-in-class molecule for ... improvements compared to placebo in the Phase 3 SPARTAN ... 18th Congress of the International Headache Society (IHC) in ... presented today demonstrate lasmiditan,s potential to reduce pain and ...
Breaking Medicine Technology: