Navigation Links
Cocoa extract may counter specific mechanisms of Alzheimer's disease
Date:6/23/2014

(NEW YORK June 23) A specific preparation of cocoa-extract called Lavado may reduce damage to nerve pathways seen in Alzheimer's disease patients' brains long before they develop symptoms, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 20 in the Journal of Alzheimer's Disease (JAD).

Specifically, the study results, using mice genetically engineered to mimic Alzheimer's disease, suggest that Lavado cocoa extract prevents the protein β-amyloid- (Aβ) from gradually forming sticky clumps in the brain, which are known to damage nerve cells as Alzheimer's disease progresses.

Lavado cocoa is primarily composed of polyphenols, antioxidants also found in fruits and vegetables, with past studies suggesting that they prevent degenerative diseases of the brain.

The Mount Sinai study results revolve around synapses, the gaps between nerve cells. Within healthy nerve pathways, each nerve cell sends an electric pulse down itself until it reaches a synapse where it triggers the release of chemicals called neurotransmitters that float across the gap and cause the downstream nerve cell to "fire" and pass on the message.

The disease-causing formation of Aβ oligomers groups of molecules loosely attracted to each other build up around synapses. The theory is that these sticky clumps physically interfere with synaptic structures and disrupt mechanisms that maintain memory circuits' fitness. In addition, Aβ triggers immune inflammatory responses, like an infection, bringing an on a rush of chemicals and cells meant to destroy invaders but that damage our own cells instead.

"Our data suggest that Lavado cocoa extract prevents the abnormal formation of Aβ into clumped oligomeric structures, to prevent synaptic insult and eventually cognitive decline," says lead investigator Giulio Maria Pasinetti, MD, PhD, Saunders Family Chair and Professor of Neurology at the Icahn School of Medicine at Mount Sinai. "Given that cognitive decline in Alzheimer's disease is thought to start decades before symptoms appear, we believe our results have broad implications for the prevention of Alzheimer's disease and dementia.

Evidence in the current study is the first to suggest that adequate quantities of specific cocoa polyphenols in the diet over time may prevent the glomming together of Aβ into oligomers that damage the brain, as a means to prevent Alzheimer's disease.

The research team led by Dr. Pasinetti tested the effects of extracts from Dutched, Natural, and Lavado cocoa, which contain different levels of polyphenols. Each cocoa type was evaluated for its ability to reduce the formation of Aβ oligomers and to rescue synaptic function. Lavado extract, which has the highest polyphenol content and anti-inflammatory activity among the three, was also the most effective in both reducing formation of Aβ oligomers and reversing damage to synapses in the study mice.

"There have been some inconsistencies in medical literature regarding the potential benefit of cocoa polyphenols on cognitive function," says Dr. Pasinetti. "Our finding of protection against synaptic deficits by Lavado cocoa extract, but not Dutched cocoa extract, strongly suggests that polyphenols are the active component that rescue synaptic transmission, since much of the polyphenol content is lost by the high alkalinity in the Dutching process."

Because loss of synaptic function may have a greater role in memory loss than the loss of nerve cells, rescue of synaptic function may serve as a more reliable target for an effective Alzheimer's disease drug, said Dr. Pasinetti.

The new study provides experimental evidence that Lavado cocoa extract may influence Alzheimer's disease mechanisms by modifying the physical structure of Aβ oligomers. It also strongly supports further studies to identify the metabolites of Lavado cocoa extract that are active in the brain and identify potential drug targets.

In addition, turning cocoa-based Lavado into a dietary supplement may provide a safe, inexpensive and easily accessible means to prevent Alzheimer's disease, even in its earliest, asymptomatic stages.


'/>"/>

Contact: Elizabeth Dowling
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. (Sakai, Japan Xocai Cocoa Cosmeceutical News Update): Xophoria "Ripped and Rich" MLM #1 Lip Plump Program Gains Fame in Hyogo and Hiroshima
2. (Sendai Japan MXI Corp Cocoa "Personal Care" Update): Xophoria "Ripped and Rich" MLM Hair Shampoo Program Gains Notoriety in Takatsuki and Takarazuka
3. (Saitama, Japan MXI Corp Cocoa "Weight Loss" Update): Xophoria "Ripped and Rich" MLM Body Wash Program Gains Popularity in Wakayama and Chigasaki
4. Defense Nutrition Introduces CoCoMadness™ the First All Natural Cocoa Energy Chewable
5. Cocoa and Drinking Chocolate Production in the US Industry Market Research Report Now Available from IBISWorld
6. InVite® Health Introduces New and Improved Antioxidant Product – Cocoa Tx™
7. Pure Cocoa Powder, the Key Ingredient in Dark Chocolate and Found in Diabetes Support Supplements has been Clinically Proven to Reduce Cardiovascular Risk
8. First validated method for analyzing flavanols and procyanidins in cocoa products could help scientists and the industry in standardized reporting
9. Geranium extracts inhibit HIV-1
10. Satiereal Saffron Extract Review - The Natural Appetite Suppressant Supplement is Now Available for Sale With Extra Discount Offer as New Year Special
11. Dr. Oz Graviola Extract - The Natural Health Supplement is Now Available for Sale With Extra Discount Offer as New Year Special
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... (PRWEB) , ... May 24, ... ... announcement of Essette Dashboard, its highly anticipated, web-based software module. The cutting-edge ... The application’s “secret sauce”? Integration with Izenda’s self-service business intelligence solution and ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... anniversary and has kicked off its 5th Annual Photo Contest. The label contest ... annual event. This year's prizes include a GoPro Hero4, a 40-inch high-definition flat-screen ...
(Date:5/23/2016)... ... May 23, 2016 , ... On Sunday, May 15, ... million, 64-room assisted living center. After 18 months of construction, the new state-of-the-art ... new building provides the latest in assisted living amenities and services, offering six ...
(Date:5/23/2016)... ... 2016 , ... Edward D. Buckingham, M.D . is excited announce that ... roster is put out by the National Consumer Advisory Board to honor excellence in ... considered for this award. , The National Consumer Advisory Board (NCAB) is a private ...
(Date:5/23/2016)... ... , ... According to an article published May 11th on The ... who could benefit from bariatric surgery are actually undergoing the procedure. The article explains ... it offers to obese patients from 6,000 to 50,000 a year, it will not ...
Breaking Medicine News(10 mins):
(Date:5/22/2016)... 23, 2016 DS Biopharma ... and anti-inflammatory compound DS102 in chronic obstructive pulmonary ... steatohepatitis (NASH) patients. Recent DS preclinical ... lung tissue and has bronchodilatory, anti-inflammatory and anti-fibrotic ... The Company will publish further detail on these ...
(Date:5/20/2016)... ReportsnReports.com adds "Plaque Psoriasis ... research report with comprehensive information on the therapeutic ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
(Date:5/19/2016)... Oregon , May 19, 2016 ... titled, World Medical/Diagnostic Imaging Market -Opportunities and Forecasts, 2015 ... reach $45.0 billion by 2022, registering a CAGR of ... expected to continue to be the highest revenue-generating segment ... accounted for around one-third of the market share ...
Breaking Medicine Technology: