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Cocktail boosts immune cells in fighting cancer
Date:12/6/2012

aptive immune system," says Cerwenka.

However, NK cells were only able to let tumors shrink if the mice had undergone prior radiation treatment. The scientists found a lot more NK cells at their site of action in tumor tissue in irradiated mice than in control animals. Cerwenka and colleagues do not yet know the precise molecular reason for this observation. "The good thing is that we might be able to achieve this effect in a potential clinical application by combining the cocktail-treated NK cells with radiation therapy."

Cocktail-treated human NK cells also display all molecular signs of sustained activation in cell culture. Adelheid Cerwenka and her team have already started testing the effectiveness of killer cells in fighting human cancer cells. "We hope to advance the development of NK cell therapies against cancer with our novel approach," says Cerwenka.


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Contact: Dr. Sibylle Kohlstdt
s.kohlstaedrt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

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