Navigation Links
Cocaine Spurs Long-Term Change in Brain Chemistry

Study in mice finds drug alters gene activity, points to new methods for treatment

THURSDAY, May 14 (HealthDay News) Many remember those fried-egg "this is your brain on drugs" public service announcements. Now, a new study offers insight into how addictive drugs such as cocaine "cook" the brain.

"The study's findings enable us to glimpse for the first time exactly how cocaine modifies the activity of genes in regions of the brain that that mediate reward," explained Nora Volkow, the director of the U.S. National Institute on Drug Abuse, the organization that supported the study. "These genes represent promising new targets for the development of medications to treat cocaine addiction," she said.

Scientists led by Dr. Eric Nestler, of New York's Mount Sinai School of Medicine, used a new molecular analysis technique to watch changes in the gene activity of mice that were injected with cocaine. The changes involve a shift in proteins called histones and transcription factors, which bind to DNA and regulate how the genetic information in a DNA strand is read to make a complementary sequence of RNA. A cell uses the information in the RNA to make final protein products.

Using these genetic markers, scientists mapped the effects of drug use in a critical part of the brain's "reward circuitry."

The process showed, for the first time, that a family of genes called the sirtuins are activated by chronic cocaine use and fuel addiction-related behaviors in lab animals.

The research was published May 14 in the journal Neuron.

"This analysis provides fundamentally new information about the range of genes that are altered by cocaine in this brain region," Nestler said. "We showed that blocking the activity of the sirtuins reduced both cocaine's rewarding effects and the motivation to self-administer the drug."

In other words, scientists may someday be able to take away the desire for cocaine as well as the pleasure a person gets from using it, the researchers said.

More information

The U.S. National Institute on Drug Abuse has more on cocaine.

-- Dennis Thompson

SOURCE: U.S. National Institute on Drug Abuse, news release, May 13, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. Drug Detection Kits Manufactured By IDenta Corp. Shown During French Television Broadcast (at TF1) - Product Aids French Police In Bust of 600 Kilograms Of Cocaine
3. Cocaine Use Dulls Brains Sensitivity to Rewards
4. $2.2M NIH grant to develop drugs to suppress cocaine cravings
5. Catalyst Pharmaceutical Partners Announces Positive Phase II Trial Results for Vigabatrin in the Treatment of Cocaine Addiction
6. Cocaines effects on brain metabolism may contribute to abuse
7. Use of Methamphetamine Among U.S. Workers and Job Applicants Drops 22 Percent in 2007 and Cocaine Use Slows Dramatically, Reports Quest Diagnostics
8. Subordinate monkeys more likely to choose cocaine over food
9. Animal research suggests new strategy for treating cocaine addiction
10. Gene therapy reduces cocaine use in rats
11. Gene Therapy in Rats Reduces Cocaine Use
Post Your Comments:
Related Image:
Cocaine Spurs Long-Term Change in Brain Chemistry
(Date:10/12/2015)... ... October 13, 2015 , ... Career Step, an online ... of its new Professional Medical Coding and Billing with Applied PCS career training ... ICD-10-PCS code sets, earn the Certified Professional Coder (CPC) and Certified Coding Associate ...
(Date:10/12/2015)... , ... October 12, 2015 , ... ... August 19, 2015, high school aged female athletes, particularly in the area of ... repetitive motion and mechanical overuse injuries than male peers in the same age ...
(Date:10/12/2015)... Los Angeles, CA (PRWEB) , ... October 12, 2015 , ... ... 7th, the Fire Chief for the city of San Antonio, Texas recommended that any ... retrofitted to incorporate these important safety systems going forward. The article explains that it ...
(Date:10/12/2015)... ... October 12, 2015 , ... AcousticSheep LLC, ... Cleveland Clinic in honor of Breast Cancer Awareness Month. During the month ... will donate a SleepPhones® Classic product to a breast cancer patient at the ...
(Date:10/12/2015)... (PRWEB) , ... October 12, 2015 , ... On July ... MN. Their mission: To paddle the entire 2,320-miles of river to the Gulf of ... halfway done with the monumental journey, with two months remaining for a November 22nd ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... 12, 2015 Device usage in healthcare continues ... integrate these devices into existing clinical workflow. In response, ... and mobility solutions, has launched the SV10 series of ... a wide array of laptops and tablets. In addition, ... exclusively for Microsoft Surface and is compatible with all ...
(Date:10/12/2015)... October 12, 2015 ... to grow at 7.2% CAGR, microscopy market ... rising focus on nanotechnology, technological advancements, and ... report available with ... . --> Complete report on ...
(Date:10/12/2015)... Oct. 12, 2015 Indivior PLC (LON: INDV) today ... Delaware granted the Company,s motion to ... New Drug Application (ANDA) No. 205299 to market a generic ... naloxone) Sublingual Film (CIII) in the United States ... Since August 2013, Indivior has received Paragraph IV certifications from ...
Breaking Medicine Technology: