Coalition for Pulmonary Fibrosis and American Thoracic Society Announce Recipients of 2009-10 Resea... ( CPF and ATS to Jointly Award $200000 ...)

Coalition for Pulmonary Fibrosis and American Thoracic Society Announce Recipients of 2009-10 Research Awards

Date:2/4/2009

CPF and ATS to Jointly Award $200,000 to Advance Understanding and Treatment of Pulmonary Fibrosis (PF)

SAN JOSE, Calif., Feb. 4 /PRNewswire-USNewswire/ -- The Coalition for Pulmonary Fibrosis (CPF) and the American Thoracic Society (ATS), the world's leading professional organization for pulmonary, critical care and sleep physicians, today announced that Melissa Hunter, Ph.D. from Ohio State University Medical Center (Columbus, OH) and Harikrishna Tanjore, Ph.D. from Vanderbilt University Medical Center (Nashville, TN) were selected as recipients of the 2009-2010 ATS/CPF Partnership Grants for Pulmonary Fibrosis.

Dr. Hunter, a Research Assistant Professor in the Department of Pulmonary, Allergy, Critical Care & Sleep Medicine at OSU, is the recipient of a two-year, $100,000 award to investigate "MicroRNA Regulation in Idiopathic Pulmonary Fibrosis." Preliminary data from the OSU laboratory indicate that the expression of several miRNAs -- small regulatory RNAs that regulate gene expression -- encoded by the "miR-17~92 cluster" are decreased in the lungs of IPF/ILD patients, as well as mice treated with bleomycin to induce lung fibrosis. Dr. Hunter will investigate whether the loss of expression of this cluster contributes to the pathogenesis of pulmonary fibrosis. The ultimate goal of this study is to identify new biomarkers and molecular targets in patients with IPF/ILD.

Dr. Tanjore, Research Assistant Professor Department of Allergy, Pulmonary & Critical Care Medicine at Vanderbilt, is the recipient of a two-year, $100,000 award to investigate "Contribution of Epithelial Mesenchymal Transition (EMT) to Pulmonary Fibrosis." EMT is induced by transforming growth factor beta signaling in the alveolar epithelium and plays a pivotal role in determining whether the response to tissue injury leads to normal repair or lung fibrosis. Dr. Tanjore's study se
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