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Clues to pregnancy-associated breast cancer found
Date:3/29/2010

Expression of inflammatory-related genes in breast tissue of women who have previously given birth may explain the aggressiveness and frequency of pregnancy-associated breast cancer, according to new research at the University of Illinois at Chicago.

Pregnancy at a relatively young age reduces the risk of breast cancer over the long term, but epidemiological studies have found that women are at an increased risk for breast cancer during pregnancy and for up to 10 years after giving birth, said Debra Tonetti, associate professor of pharmacology and lead researcher on the study. These pregnancy-associated breast cancers also carry an unusually high risk of spreading to nearby organs and for lethality as compared to breast cancers in women who have never been pregnant, she said.

Tonetti and her research team examined the level of expression of 64 genes in tissue from benign breast biopsies and breast-reduction surgeries at the University of Illinois Medical Center at Chicago. The women, who were between the ages of 18 and 45, were divided into three categories: those who had never been pregnant, those who had been pregnant within the past two years, and those who had been pregnant five to 10 years previously.

The set of examined genes included genes known to be related to immunity and inflammation, extracellular matrix remodeling, angiogenesis (the growth of new blood vessels vital to wound healing) or hormone signaling.

Twenty-two percent of the examined genes showed significant difference in expression in the breast tissue of women who had never given birth compared with those who had. Inflammation-related genes, as a class, were more active in women who had borne a child. Involution -- the process by which the breast returns to normal following lactation -- could be a cause of the inflammation, she said.

"Our results showed an increase in immune/inflammatory activity in the post-pregnant breast," Tonetti said. "
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Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

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