Navigation Links
Clues Found to Brain Mechanism Behind Migraines

Study in mice pinpoints role of gene mutation in triggering certain headaches

WEDNESDAY, March 11 (HealthDay News) -- Scientists believe they may have found the biological trigger to a particular type of migraine headache.

In the March 12 issue of Neuron, an Italian university study on mice found that increased levels of the neurotransmitter glutamate in the brain appear to kick off a cortical spreading depression (CSD), a phenomenon that causes migraine sufferers to experience a visual disturbance known as migraine aura. The mice in the study had a gene mutation that has been shown to make people more susceptible to familial hemiplegic migraine (FHM), a subtype of severe migraine accompanied by the aura.

Brain imaging has previously shown that strong neuronal depolarization creeps across the cerebral cortex during CSD, initially increasing electrical signals in the brain, then suppressing neural activity for an extended period of time. Researchers have suspected CSD may flip on certain switches that start a migraine headache.

The researchers from the University of Padova, led by senior author Daniela Pietrobon, found that calcium influx and subsequent glutamate release at cortical pyramidal cell synapses were greater in mice with the FHM mutation. When the release of glutamate -- the major excitatory neurotransmitter in the brain -- was decreased to normal levels, the mice did not experience aura-inducing CSD.

"Our findings provide direct evidence that enhanced glutamate release may explain the facilitation of CSD in the FHM mouse model," Pietrobon, who works in the university's biomedical sciences department, said in a news release issued by the journal's publisher.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about migraines.

-- Kevin McKeever

SOURCE: Cell Press, news release, March 11, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Fasting Signal Offers Clues to Insulin Resistance in the Obese
2. Vitamin A signals offer clues to treating autoimmunity
3. CMV Infection in Solid Organ Transplantation: Clinical Clues and Prevention Strategies
4. New clues to healing arthritis caused by traumatic injury
5. Mutant rats offer clues to medical mystery
6. New Clues to Stopping Colitis-Linked Cancer
7. Physics, Math Provide Clues to Unraveling Cancer
8. Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack
9. Study yields clues about the evolution of epilepsy
10. Mutant Mouse Gene Offers Clues to Hearing Loss
11. Study provides clues to preventing and treating cancer spread
Post Your Comments:
Related Image:
Clues Found to Brain Mechanism Behind Migraines
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC ... by obtaining investment capital for emerging technology companies. SCP has delivered investment ... resulted in more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
(Date:6/24/2016)... Gilbert, Arizona (PRWEB) , ... June 24, 2016 ... ... Gilbert-based practice, is supporting the upcoming 2016 Miss Arizona pageant as its official ... primarily serves Scottsdale, Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
Breaking Medicine Technology: