Navigation Links
Clues Found to Brain Mechanism Behind Migraines
Date:3/11/2009

Study in mice pinpoints role of gene mutation in triggering certain headaches

WEDNESDAY, March 11 (HealthDay News) -- Scientists believe they may have found the biological trigger to a particular type of migraine headache.

In the March 12 issue of Neuron, an Italian university study on mice found that increased levels of the neurotransmitter glutamate in the brain appear to kick off a cortical spreading depression (CSD), a phenomenon that causes migraine sufferers to experience a visual disturbance known as migraine aura. The mice in the study had a gene mutation that has been shown to make people more susceptible to familial hemiplegic migraine (FHM), a subtype of severe migraine accompanied by the aura.

Brain imaging has previously shown that strong neuronal depolarization creeps across the cerebral cortex during CSD, initially increasing electrical signals in the brain, then suppressing neural activity for an extended period of time. Researchers have suspected CSD may flip on certain switches that start a migraine headache.

The researchers from the University of Padova, led by senior author Daniela Pietrobon, found that calcium influx and subsequent glutamate release at cortical pyramidal cell synapses were greater in mice with the FHM mutation. When the release of glutamate -- the major excitatory neurotransmitter in the brain -- was decreased to normal levels, the mice did not experience aura-inducing CSD.

"Our findings provide direct evidence that enhanced glutamate release may explain the facilitation of CSD in the FHM mouse model," Pietrobon, who works in the university's biomedical sciences department, said in a news release issued by the journal's publisher.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about migraines.



-- Kevin McKeever



SOURCE: Cell Press, news release, March 11, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Fasting Signal Offers Clues to Insulin Resistance in the Obese
2. Vitamin A signals offer clues to treating autoimmunity
3. CMV Infection in Solid Organ Transplantation: Clinical Clues and Prevention Strategies
4. New clues to healing arthritis caused by traumatic injury
5. Mutant rats offer clues to medical mystery
6. New Clues to Stopping Colitis-Linked Cancer
7. Physics, Math Provide Clues to Unraveling Cancer
8. Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack
9. Study yields clues about the evolution of epilepsy
10. Mutant Mouse Gene Offers Clues to Hearing Loss
11. Study provides clues to preventing and treating cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clues Found to Brain Mechanism Behind Migraines
(Date:12/7/2016)... Kenosha, Wisconsin (PRWEB) , ... December 07, 2016 , ... ... the extraordinary new MedMaster™ MPCNGX . The MPCNGX is a multi-function, sealed, LED ... the right amount of light where and when it’s needed. , A ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... to treat wrinkles and deep lines by smoothing and tightening the skin of ... techniques out there to address facial aging with very little downtime, Silhouette Instalift ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... a women growing up with a schizophrenic mother in a unique, personal perspective ... who specializes in treating trauma and addictive disorders at her private psychotherapy practice. ...
(Date:12/7/2016)... ... December 07, 2016 , ... In the early morning ... to an emergency medical call when he lost control of his patrol car. The ... from his vehicle, he was transported to Atlanta Medical Center, where he later succumbed ...
(Date:12/7/2016)... , ... December 07, 2016 , ... Castle Dermatology Institute ... several ways to restore a more youthful appearance to the face. Dr. Peyman Ghasri ... along with a variety of other treatments, to rejuvenate and renew the facial appearance. ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Biosimilar Clinical Trial & Opportunity Insight" report by PNS Pharma gives comprehensive ... Currently 5 biosimilar version of Lantus are commercially available in ... , Czech Republic , Estonia , ... Slovakia , United Kingdom for the treatment ... in 2014. Lantus is the brand name for Insulin Glargine, a ...
(Date:12/7/2016)... Global Cervical Dysplasia Market: Scope and ... dysplasia market analyzes the current and future prospects ... executive summary, including a market snapshot that provides ... The research is a combination of primary and ... our research efforts along with information collected from ...
(Date:12/7/2016)... -- A new investigational drug originally developed for type 2 ... of the world,s first treatment to impede the progression of ... in the journal Science Translational Medicine . ... for millions of people living with Parkinson,s disease," says ... Research Institute,s Center for Neurodegenerative Science , chairman ...
Breaking Medicine Technology: