Clue to switch of bladder cancer from locally contained to invasive found by Jefferson ... ( (PHILADELPHIA) Bladder cancer often...)

Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists

Date:5/14/2010

(PHILADELPHIA) Bladder cancer often becomes aggressive and spreads in patients despite treatment, but now researchers at the Kimmel Cancer Center at Jefferson have identified a protein they believe is involved in pushing tumors to become invasive and deadly.

"We have found that IGF-IR is a critical regulator of motility and invasion of bladder cancer cells, and this could offer us a novel molecular target to treat patients with this cancer in order to prevent metastasis," said the lead investigator, Andrea Morrione, Ph.D., a research associate professor of Urology at Jefferson Medical College, and director of Urology Research, Kimmel Cancer Center.

This finding is promising, they say in the June issue of American Journal of Pathology, because there are about a dozen agents targeted against the protein, the insulin-like growth factor receptor I (IGF-IR), that are now undergoing clinical testing to treat a variety of patient tumors.

"Testing presence of the protein could also serve as a novel tumor biomarker for diagnosis, and possibly prognosis of bladder tumors," he added.

Although bladder cancer is common, the molecular mechanisms that push the cancer to become invasive and to spread are still poorly understood, say the researchers. Although most bladder cancers are caught early and treated, they often come back and become aggressive, despite subsequent therapy with surgery, chemotherapy, or immunotherapy.

In this study, the researchers looked at the role of the protein receptor for the growth factor IGF-I, an important modulator of cell proliferation in bladder cancer cells. They found that although activation of IGF-IR did not affect growth of bladder cancer cells, it did promote the migration and invasion of these cells. The researchers showed that IGF-IR activated other molecules in cancer-promoting pathways (Akt and MAPK) that allow cancer cells to break its bond with other cells in a tumor in ord
'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Brains master switch is verified by Iowa State University researcher
2. UBC graduate student finds a start/stop switch for retroviruses
3. Discovery of cellular switch may provide new means of triggering cell death, treating disease
4. Researchers discover brain tumors grow-or-go switch
5. Daylight-Saving Time Switch May Leave You Sleepy, U-M Physician Says
6. BCS Global Launches PSVN (Public Switched Video Network), an Initiative to Provide a Framework for Inter-Connecting Business to Business Video Networks
7. Researchers create drug to keep tumor growth switched off
8. Cochlear Appoints Switched on Media to Develop its SEO Across the Asia Pacific Region
9. Scientists show how molecular switch helps pancreatic cancer beat drugs
10. Boston Celtics Captain Paul Pierce Partners with Switch2Health to Inspire Youth to Lead Healthier Lifestyles through Innovative Rewards-based Fitness System
11. Lack of cellular enzyme triggers switch in glucose processing

Post Your Comments:

(Date:5/25/2013)... May 25, 2013 This week idcloak Technologies ... to Facebook in countries where the site is blocked. ... user faces none of the site compatibility problems associated with ... Technologies, explains how a user may apply IP Port proxies ... the benefits of doing so are. , “When a user ...

(Date:5/25/2013)... NYC,NY (PRWEB) May 25, 2013 Dr. ... only non-invasive procedure FDA-approved to lift skin on the neck, ... available at her practice, Medical Aesthetics. , Ultherapy is a ... body’s own natural healing process to lift the skin over ... the first time, to see and then treat the deepest ...

(Date:5/25/2013)... 25, 2013 Actos lawsuit ... U.S. District Court, Western District of Louisiana, continue to ... a Case Management Order issued on May 21st, the ... contested motions in the Actos bladder cancer litigation, as ... Actos Product Liability Litigation, MDL No. 2299) , “We ...

(Date:5/25/2013)... TX (PRWEB) May 25, 2013 Studies ... those who are carrying excessive weight and their inability ... for many, simply losing weight can naturally relieve many ... found that improvement in sleep quality was significantly associated ... six month study dated November 6th, 2012, ...

(Date:5/25/2013)... 2013 The latest report from ... bowel syndrome (IBS) to bloating, constipation, diarrhea and ... long-lasting, embarrassing, frustrating and difficult health issues to ... health have provided a cure for these ... contributing to digestive health issues, a healthy diet ...

Breaking Medicine News(10 mins):Health News:idcloak Launches Proxy Web Browser for Blocked Facebook Users 2 Health News:Dr. Leslie Gerstman Is Now Offering the Non-surgical Facelifting Procedure – Ultherapy – in NYC and NJ 2 Health News:Actos Lawsuit News: Bernstein Liebhard LLP Notes New Case Management Order in Federal Actos Bladder Cancer Litigation 2 Health News:Actos Lawsuit News: Bernstein Liebhard LLP Notes New Case Management Order in Federal Actos Bladder Cancer Litigation 3 Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Newly Improved hCG Diet Plans Capable of Delivering Better Sleep 2 Health News:Natural Foods For Digestive Health Report and Video Published by BetterDigestion.org 2

[0] idcloak Launches Proxy Web Browser for Blocked Facebook Users [0] Dr. Leslie Gerstman Is Now Offering the Non-surgical Facelifting Procedure – Ultherapy – in NYC and NJ [0] Actos Lawsuit News: Bernstein Liebhard LLP Notes New Case Management Order in Federal Actos Bladder Cancer Litigation [0] hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Newly Improved hCG Diet Plans Capable of Delivering Better Sleep [0] Natural Foods For Digestive Health Report and Video Published by BetterDigestion.org

... hearing loss in laboratory animals, according to two new ... of a pill that could stave off noise-induced and ... findings will be reported Wednesday at the Association for ... author Colleen Le Prell, Ph.D., a researcher at the ...

... National Head Start Association (NHSA) issued the following statement ... is the director of the Albina Head Start program ... be created -- and more than 200,000 existing jobs ... has signed into law the economic recovery package containing ...

... Quarterly EPS of $0.39, Total Revenues of $109.1 Million ... Total Revenues by 17% -- Company Generates $178.3 Million ... Gen-Probe Incorporated (Nasdaq: GPRO ... quarter and full year ended December 31, 2008, including ...

... MADISON, Wis., Feb. 17 /PRNewswire-FirstCall/ -- Cogdell ... appointment of Roger Herritz as President of the Midwest ... Inpatient Project Delivery for the Company,s wholly owned subsidiary, ... the Company,s Madison office, Mr. Herritz will be responsible ...

... Lingering physical effects of cancer a likely cause, finds study, ... fighting cancer wasn,t hard enough, a new Dutch study concludes ... be able to find a job. , The meta-analysis of ... those who,d battled cancer were out of work vs. 15.2 ...

... sent today to,President Obama and members of the ... leadership of Congress on the enactment of,the American ... the first time,provides financial incentives to physicians who ... improve both the quality and cost-,effectiveness of patient ...

Vitamin supplements may protect against noise-induced hearing loss NHSA: President Obama, Congress Deserve High Praise for $2.1 Billion in Recovery Package for Head Start Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2008 Cogdell Spencer Names Herritz and Wolters to Key Leadership Positions Within Erdman One in Three Cancer Survivors on Unemployment Line Allscripts Applauds Economic Stimulus Incentives Rewarding Physicians for Using Electronic Health Records

(Date:5/24/2013)... BEIJING , May 24, 2013 China ... "Company"), a leading fully integrated plasma-based biopharmaceutical company in ... Company has recently learned from a public announcement issued ... a public company listed on Shenzhen Stock Exchange, that ... Chan ("Ms. Chan"), one of the shareholders ...

(Date:5/24/2013)... , May 24, 2013 In accordance with Rule ... Rule 14e-1 of the United States Exchange Act, Echo Pharma ... offer for Elan Corporation (NYSE: ELN). Background ... Pharma") made an offer for the entire of the issued ... ("Elan") (the "Original Offer"). On 20 May ...

(Date:5/24/2013)... The potential of the pulmonary route as ... has been receiving undeniable attention with the recent advances ... crucial formulation considerations for orally inhaled products together with ... in the efficiency of pulmonary delivery, and great strides ... techniques and devices in recent years. With ...

[0] China Biologic Comments on the Proposed Shanghai RAAS Transaction [0] Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements [0] Inhalaltion Drug Delivery: 11-12 September - Berlin, Germany

... 2011 Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) ... quarter and full year 2010 on Wednesday, January 26, 2011 ... president and chief executive officer, will lead the call. On ... the fourth quarter and year ended December 31, 2010. ...

... Applied Precision is pleased to announce that ... Dougherty, senior scientist, have been chosen to present ... BiOS SPIE Photonics West. Three-dimensional ... that doubles the lateral and axial resolution, providing ...

Cached Medicine Technology:Amylin Pharmaceuticals to Webcast Year-End Financial Results 2 Applied Precision Scientific Team to Present 3D-SIM Paper at BiOS in San Francisco 2

Amylin Pharmaceuticals to Webcast Year-End Financial Results Applied Precision Scientific Team to Present 3D-SIM Paper at BiOS in San Francisco

The MACS VA_500 (variable atmosphere) is primarily for the study and isolation of microaerophilic organisms,including Campylobacter spp,Helicobacter pylori and other similarly fastdious organisms....

... an electrical power supply, MERKUR offers a broad ... a gas spring for ease of operation. For ... a foot pedal hydraulic system. Thanks to its ... anytime in a highly mobile and flexible manner. ...

... table MARS Enduro is the ideal ... are required before, during or directly ... motorised longitudinal adjustment and the filigreed ... conditions in examination, induction and operating ...

... Top Rotation provides uncommon bi-directional flexibility, ... Hercules 6700B eliminates any conflicts between ... while providing ample leg room for ... procedures. Removable back and leg sections ...

Medicine Products:

VA-500 Merkur Mars Enduro Hercules 6700B