Navigation Links
Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
Date:5/14/2010

(PHILADELPHIA) Bladder cancer often becomes aggressive and spreads in patients despite treatment, but now researchers at the Kimmel Cancer Center at Jefferson have identified a protein they believe is involved in pushing tumors to become invasive and deadly.

"We have found that IGF-IR is a critical regulator of motility and invasion of bladder cancer cells, and this could offer us a novel molecular target to treat patients with this cancer in order to prevent metastasis," said the lead investigator, Andrea Morrione, Ph.D., a research associate professor of Urology at Jefferson Medical College, and director of Urology Research, Kimmel Cancer Center.

This finding is promising, they say in the June issue of American Journal of Pathology, because there are about a dozen agents targeted against the protein, the insulin-like growth factor receptor I (IGF-IR), that are now undergoing clinical testing to treat a variety of patient tumors.

"Testing presence of the protein could also serve as a novel tumor biomarker for diagnosis, and possibly prognosis of bladder tumors," he added.

Although bladder cancer is common, the molecular mechanisms that push the cancer to become invasive and to spread are still poorly understood, say the researchers. Although most bladder cancers are caught early and treated, they often come back and become aggressive, despite subsequent therapy with surgery, chemotherapy, or immunotherapy.

In this study, the researchers looked at the role of the protein receptor for the growth factor IGF-I, an important modulator of cell proliferation in bladder cancer cells. They found that although activation of IGF-IR did not affect growth of bladder cancer cells, it did promote the migration and invasion of these cells. The researchers showed that IGF-IR activated other molecules in cancer-promoting pathways (Akt and MAPK) that allow cancer cells to break its bond with other cells in a tumor in ord
'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brains master switch is verified by Iowa State University researcher
2. UBC graduate student finds a start/stop switch for retroviruses
3. Discovery of cellular switch may provide new means of triggering cell death, treating disease
4. Researchers discover brain tumors grow-or-go switch
5. Daylight-Saving Time Switch May Leave You Sleepy, U-M Physician Says
6. BCS Global Launches PSVN (Public Switched Video Network), an Initiative to Provide a Framework for Inter-Connecting Business to Business Video Networks
7. Researchers create drug to keep tumor growth switched off
8. Cochlear Appoints Switched on Media to Develop its SEO Across the Asia Pacific Region
9. Scientists show how molecular switch helps pancreatic cancer beat drugs
10. Boston Celtics Captain Paul Pierce Partners with Switch2Health to Inspire Youth to Lead Healthier Lifestyles through Innovative Rewards-based Fitness System
11. Lack of cellular enzyme triggers switch in glucose processing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... The American Society for Radiation Oncology (ASTRO) has ... Radiation Therapy for Endometrial Cancer: An ASTRO Evidence-Based ... therapy in the treatment of endometrial cancer. The ... 2014 issue of Practical Radiation Oncology ... The full-length guideline is available as an open-access ...
(Date:4/23/2014)... A novel compound that targets an important brain ... cocaine addiction behaviors, including relapse behavior, a University at ... strong evidence that this may be a novel lead ... medications exist., The UB research was published as an ... , In the study, the compound, RO5263397, severely blunted ...
(Date:4/23/2014)... accessible detection methods that can rapidly screen a ... single cell inside that population has been seriously ... , In the Royal Society of Chemistry journal ... he and his coworkers have developed a novel ... protein ( Chem. Sci. , 2014, DOI: 10.1039/C4SC00578C, ...
(Date:4/23/2014)... In a country as wealthy as the United States, it ... do not have access to adequate food due to lack ... , Recent research at the University of Illinois using ... revealed that the seniors who are dealing with hunger are ... 2011, 8.35 percent of Americans over age 60 faced the ...
(Date:4/23/2014)... Leisure Time Physical Activity on Mobility Limitation in Old ... the risk of mobility limitation in old age, whereas ... in a study which followed up 5,200 public sector ... the Gerontology Research Center in Finland and the Finnish ... often repetitive, wears the body and lasts for several ...
Breaking Medicine News(10 mins):Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2Health News:More Americans in their golden years are going hungry 2Health News:Midlife occupational and leisure-time physical activity limits mobility in old age 2
... April 29 George W. Crabtree, a senior,scientist and ... Laboratory, was elected a member of the National Academy,of ... in the NAS is one of the highest honors ... Crabtree will be inducted into the Academy,next April during ...
... April 29 Warner,Chilcott Limited (Nasdaq: WCRX ) ... to settle a securities class action lawsuit pending,in the ... New York.,The suit asserted claims under the Securities Act ... those who were allegedly damaged as a result of,acquiring ...
... Children,s Hospital, SEATTLE, April 29 PEMCO ... its "Super-Long Coffee Order" promotion with,Tully,s Coffee. The ... coffee orders. PEMCO Insurance donates $1 to,Children,s Hospital ... The winners from the promotion,s third and fourth ...
... or more of blood can be life-threatening , , ... that thicken the blood are highly effective in ... University of California, San Diego, bioengineering researchers. , ... standard emergency treatment for patients with severe bleeding. ...
... quarter of those asked had borrowed, given away allergy ... News) -- If you,ve ever shared your allergy medicines, ... friend, you,ve got plenty of company: A new survey ... them from others. , However, this can be an ...
... from the American Cancer Society finds cancer survivors who ... fruits and vegetables, and getting adequate exercisehave higher health-related ... not follow such recommendations. The study, which appears in ... also finds cancer survivors have low rates of smoking, ...
Cached Medicine News:Health News:Argonne's Crabtree Elected to National Academy of Sciences 2Health News:Warner Chilcott Announces Settlement of Securities Litigation 2Health News:Warner Chilcott Announces Settlement of Securities Litigation 3Health News:PEMCO's Super-Long-Coffee-Order Contest Names Newest Winners 2Health News:Viscosity Enhancers Curb Bleeding Complications 2Health News:Many Americans Share Prescription Meds 2Health News:Cancer survivors who practice healthy habits have higher quality of life 2
(Date:1/14/2014)... Calif. , Jan. 14, 2014 The Brandeis Medical Center, ... Angeles a premier and affordable laser tattoo removal experience ... Dr. Brandeis, focus is in providing high quality cosmetic services with ... patients. " Southern California has seen ...
(Date:1/14/2014)... Animal Emergency Critical Care, a LifeCentre partner practice, located at ... is the first in Loudoun County to ... Susan M. Barnes , Medical Director, is a well-seasoned veterinarian ... Cole Taylor , are avid scuba divers. "As altitude skiers and ...
(Date:1/14/2014)... , Jan. 14, 2014   Oligomerix, Inc. , a privately ... for Alzheimer,s disease (AD) and related neurodegenerative disorders, announced ... Valhalla, NY as of January 15, ... at New York Medical College. Oligomerix, which ...
Breaking Medicine Technology:Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... ALISO VIEJO, Calif., April 7, 2011 Avanir Pharmaceuticals, ... data from a number of clinical research activities will be ... of Neurology (AAN), taking place in Honolulu, HI, at the ... details about the data presentations:Title: Burden of Pseudobulbar Affect on ...
... Texas, April 7, 2011 Luminex Corporation (Nasdaq: ... Excellence Award in the category of In Vitro Diagnostics ... is a compact, versatile laboratory analysis platform designed to ... from a single sample. (Logo:   http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ...
Cached Medicine Technology:Avanir Pharmaceuticals to Present Data at the American Academy of Neurology Annual Meeting 2Avanir Pharmaceuticals to Present Data at the American Academy of Neurology Annual Meeting 3Avanir Pharmaceuticals to Present Data at the American Academy of Neurology Annual Meeting 4Luminex Corporation Wins Prestigious Medical Design Excellence Award 2Luminex Corporation Wins Prestigious Medical Design Excellence Award 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: