Navigation Links
Clue to Cause of Epileptic Seizures Discovered
Date:11/24/2008

Finding could lead to new treatments, researchers say

MONDAY, Nov. 24 (HealthDay News) -- The interaction between white blood cells of the immune system and blood vessels may contribute to epileptic seizures, new research suggests.

If this turns out to be the case, such interactions may be a target for new treatments or even preventive measures for epilepsy, said researchers reporting in the Nov. 23 issue of Nature Medicine.

"This opens a window to a mechanism that we hadn't really seen in this way," said Dr. Robert A. Gross, director of the Strong Epilepsy Center at the University of Rochester Medical Center and deputy editor of Neurology. "But I'm not sure it gets us exactly where it needs us to be with human treatment."

Epilepsy affects some 1 percent of individuals globally. Yet, its causes and mechanisms are not well understood. Epilepsy remains a considerable medical mystery, and an outside expert said this revelation could be a productive avenue to pursue, or perhaps not.

The disorder causes a person to have seizures due to a surge of electrical activity affecting parts of the brain. The seizures can manifest in different ways.

Some 60 percent to 70 percent of all people with epilepsy respond well to a single medication, Gross said. Others may respond to a device or surgery.

"We have other means, but we clearly need other medicines and potentially different medicines," Gross said.

Recent research has suggested that activation of the immune system in the brain, and the resulting inflammation processes, may play a role in epilepsy.

These researchers, from the University of Verona in Italy, demonstrated that, in mice, seizures caused "adhesion" molecules in blood vessels in the brain to attach to white blood cells known as leukocytes.

Interrupting this interaction reduced seizures.

Seizures also broke down the blood-brain barrier, which works to keep various molecules out of the brain.

When investigators interfered with the leukocyte-blood vessel binding, the blood-brain "leak" was plugged.

Also, there were more leukocytes present in the brains of people with epilepsy, when compared with healthy individuals. As always with animal models, there is a question about how well the findings extend to apply to humans.

"How generalizable is this?" Gross asked.

More information

Visit the Epilepsy Foundation for more on this condition.



SOURCES: Robert A. Gross, M.D., Ph.D., director, Strong Epilepsy Center, and professor, neurology and pharmacology and physiology, University of Rochester Medical Center, N.Y.; Nov. 23, 2008, Nature Medicine, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Jersey Jury Awards $12.9 Million to Three Patients Whose Use of Roche Acne Medication Accutane Found to Cause Severe Bowel Illness
2. Study identifies causes of bone loss in breast cancer survivors
3. Spinal Anesthesia Doesnt Cause Restless Leg Syndrome
4. Study Suggests Need for More Aggressive Outpatient Monitoring of Patients Hearts When Cause of Stroke is Unclear
5. Mexican Department of Public Health to Launch Screening for Papillomavirus, Cause of Cervical Cancer
6. NLPC Criticizes Obamas Choice of Eric Holder for Attorney General Because of Role in Health Care Task Force Cover-Up
7. Antibiotics can cause pervasive, persistant changes to microbiota in human gut
8. Gulf War research panel finds 1 in 4 veterans suffers from illness caused by toxic exposure
9. Chemical in Plastics May Cause Fertility Problems
10. Caring.com and Alzheimer's Association Use Social Media to Help Spread Awareness for the Nation's Sixth Leading Cause of Death
11. Airport malaria -- cause for concern in the US
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clue to Cause of Epileptic Seizures Discovered
(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an ... families in and around the Cape Coral area, is embarking on a charity drive ... of Southwest Florida. , The Harry Chapin Food Bank of Southwest Florida works to ...
(Date:12/8/2016)... ... December 08, 2016 , ... Bill Mull Agencies, a Wichita-based ... and around central Kansas, is joining the Youth Horizons organization for a charity ... Headquartered in Wichita, Youth Horizons works to empower area children from unstable, troubled, ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... the passage of the most comprehensive mental health systems reform legislation in more ... of the President, and the commitment of our elected officials to improving mental ...
(Date:12/7/2016)... ... December 07, 2016 , ... Silhouette Instalift is a ... smoothing and tightening the skin of the face to create more youthful features. ... with very little downtime, Silhouette Instalift is a novel, minimally invasive facial procedure ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... S.L. (“Presence”) for a purchase price of approximately $17.4 million (net of ... annual revenue is approximately $13.2 million. Headquartered in Barcelona, Spain, Presence is ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 Dignitana, a world ... partnership with Boa® Technology, creator of the award-winning, patented ... for use with the DigniCap® scalp cooling system. DigniCap® ... in December 2015, and is the first medical scalp ... DigniCap® scalp cooling system features a patented tight-fitting silicone ...
(Date:12/8/2016)... , December 8, 2016 ... Excipients Market by Product (Actual Sugars, Sugar Alcohols, ... & Diluent, Tonicity Agents), Formulation (Oral, Topical, Parenteral) ... the market has witnessed healthy growth during the ... a CAGR of 4.3% between 2016 and 2021 ...
(Date:12/8/2016)... 2016  Hanson Research, an innovative leader in ... diffusion testing instruments for the pharmaceutical industry, announced ... Inc. ("Teledyne"). The move is designed to deepen ... instruments, as well as expand resources for further ... and services. Logo - http://photos.prnewswire.com/prnh/20161208/446988LOGO ...
Breaking Medicine Technology: