Navigation Links
Clue to Cause of Epileptic Seizures Discovered
Date:11/24/2008

Finding could lead to new treatments, researchers say

MONDAY, Nov. 24 (HealthDay News) -- The interaction between white blood cells of the immune system and blood vessels may contribute to epileptic seizures, new research suggests.

If this turns out to be the case, such interactions may be a target for new treatments or even preventive measures for epilepsy, said researchers reporting in the Nov. 23 issue of Nature Medicine.

"This opens a window to a mechanism that we hadn't really seen in this way," said Dr. Robert A. Gross, director of the Strong Epilepsy Center at the University of Rochester Medical Center and deputy editor of Neurology. "But I'm not sure it gets us exactly where it needs us to be with human treatment."

Epilepsy affects some 1 percent of individuals globally. Yet, its causes and mechanisms are not well understood. Epilepsy remains a considerable medical mystery, and an outside expert said this revelation could be a productive avenue to pursue, or perhaps not.

The disorder causes a person to have seizures due to a surge of electrical activity affecting parts of the brain. The seizures can manifest in different ways.

Some 60 percent to 70 percent of all people with epilepsy respond well to a single medication, Gross said. Others may respond to a device or surgery.

"We have other means, but we clearly need other medicines and potentially different medicines," Gross said.

Recent research has suggested that activation of the immune system in the brain, and the resulting inflammation processes, may play a role in epilepsy.

These researchers, from the University of Verona in Italy, demonstrated that, in mice, seizures caused "adhesion" molecules in blood vessels in the brain to attach to white blood cells known as leukocytes.

Interrupting this interaction reduced seizures.

Seizures also broke down the blood-brain barrier, which works to keep various molecules out of the brain.

When investigators interfered with the leukocyte-blood vessel binding, the blood-brain "leak" was plugged.

Also, there were more leukocytes present in the brains of people with epilepsy, when compared with healthy individuals. As always with animal models, there is a question about how well the findings extend to apply to humans.

"How generalizable is this?" Gross asked.

More information

Visit the Epilepsy Foundation for more on this condition.



SOURCES: Robert A. Gross, M.D., Ph.D., director, Strong Epilepsy Center, and professor, neurology and pharmacology and physiology, University of Rochester Medical Center, N.Y.; Nov. 23, 2008, Nature Medicine, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Jersey Jury Awards $12.9 Million to Three Patients Whose Use of Roche Acne Medication Accutane Found to Cause Severe Bowel Illness
2. Study identifies causes of bone loss in breast cancer survivors
3. Spinal Anesthesia Doesnt Cause Restless Leg Syndrome
4. Study Suggests Need for More Aggressive Outpatient Monitoring of Patients Hearts When Cause of Stroke is Unclear
5. Mexican Department of Public Health to Launch Screening for Papillomavirus, Cause of Cervical Cancer
6. NLPC Criticizes Obamas Choice of Eric Holder for Attorney General Because of Role in Health Care Task Force Cover-Up
7. Antibiotics can cause pervasive, persistant changes to microbiota in human gut
8. Gulf War research panel finds 1 in 4 veterans suffers from illness caused by toxic exposure
9. Chemical in Plastics May Cause Fertility Problems
10. Caring.com and Alzheimer's Association Use Social Media to Help Spread Awareness for the Nation's Sixth Leading Cause of Death
11. Airport malaria -- cause for concern in the US
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clue to Cause of Epileptic Seizures Discovered
(Date:9/20/2017)... ... September 20, 2017 , ... Ron Norman, CEO ... marketers this week about the value of senior executives, pointed to a quote ... in business has brought us to the present and will lead us into ...
(Date:9/20/2017)... ... September 20, 2017 , ... “The Foggy Road to Moorwick”: the adventures of a young Scottish ... of published author, Jeanine Liston, a busy mother of five who used her time waiting ... writing this book for over twenty years. It was a way to give some ...
(Date:9/20/2017)... ... ... “They Sang At Her Funeral”: a tale of murder that will bring a ... closets. “They Sang At Her Funeral” is the creation of published author, Annalise Harold, ... children and twelve grandchildren. Before becoming a writer, Annalise had the opportunity to relocate ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... jiu-jitsu community have raised more than $15,000 in just a couple of weeks ... submission grappling matches and world-class instructor seminars, organizers expect to double those initial ...
(Date:9/19/2017)... ... September 19, 2017 , ... DeSola Group, ... marketing leader, Denise Flannery, to its strategic advisory and client development team. ... will work with clients across different industries to develop and implement market-justified strategies, ...
Breaking Medicine News(10 mins):
(Date:8/29/2017)... RANDOLPH, N.J. , Aug. 29, 2017 ... inventory management, security, and regulatory compliance for veterinary practices ... today announced a new partnership that makes TITAN,s expertise ... legal compliance available to Cubex,s clients nationally. ... healthcare provider buying and handling controlled substances is at ...
(Date:8/28/2017)... division of LightScalpel ®, LLC, is announcing its new line of ... American veterinary laser surgery innovation, Aesculight® is revolutionizing veterinary laser surgery once ... ... VetScalpel laser. Dr. Duclos practices veterinary dermatology at the Animal Skin and ... ...
(Date:8/25/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a global ... management will be presenting a West business overview at three ... Management will present at the Baird 2017 Global Healthcare Conference, ... York, N.Y. , at 3:10 p.m. EDT on Wednesday, ... Westin Boston Waterfront in Boston, Mass. , ...
Breaking Medicine Technology: