Navigation Links
Clue to Cause of Epileptic Seizures Discovered
Date:11/24/2008

Finding could lead to new treatments, researchers say

MONDAY, Nov. 24 (HealthDay News) -- The interaction between white blood cells of the immune system and blood vessels may contribute to epileptic seizures, new research suggests.

If this turns out to be the case, such interactions may be a target for new treatments or even preventive measures for epilepsy, said researchers reporting in the Nov. 23 issue of Nature Medicine.

"This opens a window to a mechanism that we hadn't really seen in this way," said Dr. Robert A. Gross, director of the Strong Epilepsy Center at the University of Rochester Medical Center and deputy editor of Neurology. "But I'm not sure it gets us exactly where it needs us to be with human treatment."

Epilepsy affects some 1 percent of individuals globally. Yet, its causes and mechanisms are not well understood. Epilepsy remains a considerable medical mystery, and an outside expert said this revelation could be a productive avenue to pursue, or perhaps not.

The disorder causes a person to have seizures due to a surge of electrical activity affecting parts of the brain. The seizures can manifest in different ways.

Some 60 percent to 70 percent of all people with epilepsy respond well to a single medication, Gross said. Others may respond to a device or surgery.

"We have other means, but we clearly need other medicines and potentially different medicines," Gross said.

Recent research has suggested that activation of the immune system in the brain, and the resulting inflammation processes, may play a role in epilepsy.

These researchers, from the University of Verona in Italy, demonstrated that, in mice, seizures caused "adhesion" molecules in blood vessels in the brain to attach to white blood cells known as leukocytes.

Interrupting this interaction reduced seizures.

Seizures also broke down the blood-brain barrier, which works to keep various molecules out of the brain.

When investigators interfered with the leukocyte-blood vessel binding, the blood-brain "leak" was plugged.

Also, there were more leukocytes present in the brains of people with epilepsy, when compared with healthy individuals. As always with animal models, there is a question about how well the findings extend to apply to humans.

"How generalizable is this?" Gross asked.

More information

Visit the Epilepsy Foundation for more on this condition.



SOURCES: Robert A. Gross, M.D., Ph.D., director, Strong Epilepsy Center, and professor, neurology and pharmacology and physiology, University of Rochester Medical Center, N.Y.; Nov. 23, 2008, Nature Medicine, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Jersey Jury Awards $12.9 Million to Three Patients Whose Use of Roche Acne Medication Accutane Found to Cause Severe Bowel Illness
2. Study identifies causes of bone loss in breast cancer survivors
3. Spinal Anesthesia Doesnt Cause Restless Leg Syndrome
4. Study Suggests Need for More Aggressive Outpatient Monitoring of Patients Hearts When Cause of Stroke is Unclear
5. Mexican Department of Public Health to Launch Screening for Papillomavirus, Cause of Cervical Cancer
6. NLPC Criticizes Obamas Choice of Eric Holder for Attorney General Because of Role in Health Care Task Force Cover-Up
7. Antibiotics can cause pervasive, persistant changes to microbiota in human gut
8. Gulf War research panel finds 1 in 4 veterans suffers from illness caused by toxic exposure
9. Chemical in Plastics May Cause Fertility Problems
10. Caring.com and Alzheimer's Association Use Social Media to Help Spread Awareness for the Nation's Sixth Leading Cause of Death
11. Airport malaria -- cause for concern in the US
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clue to Cause of Epileptic Seizures Discovered
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history ... The Brink” is the creation of published author, William Nowers. Captain Nowers and ... WWII veteran, he spent thirty years in the Navy. Following his career as ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, Inc. ... Day Software and Consulting, LLC , and named its ... Software, based in Tennessee , will ... Day expands EnvoyHealth,s service offerings for health care partners ... "In an interoperable world, ...
(Date:9/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), ... call and webcast on Friday, November 3, 2017, beginning ... ending at approximately 8:30 a.m. (CDT) / 9:30 a.m. ... 2017 financial performance and guidance for 2018, Hill-Rom executives ... enhance operational performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... Sept. 25, 2017  EpiVax, Inc., a leader ... and immune-engineering today announced the launch of EpiVax ... of personalized therapeutic cancer vaccines. EpiVax has provided ... access to enabling technologies to the new precision ... lead EpiVax Oncology as Chief Executive Officer. Gad ...
Breaking Medicine Technology: