Navigation Links
Clue to Cause of Epileptic Seizures Discovered
Date:11/24/2008

Finding could lead to new treatments, researchers say

MONDAY, Nov. 24 (HealthDay News) -- The interaction between white blood cells of the immune system and blood vessels may contribute to epileptic seizures, new research suggests.

If this turns out to be the case, such interactions may be a target for new treatments or even preventive measures for epilepsy, said researchers reporting in the Nov. 23 issue of Nature Medicine.

"This opens a window to a mechanism that we hadn't really seen in this way," said Dr. Robert A. Gross, director of the Strong Epilepsy Center at the University of Rochester Medical Center and deputy editor of Neurology. "But I'm not sure it gets us exactly where it needs us to be with human treatment."

Epilepsy affects some 1 percent of individuals globally. Yet, its causes and mechanisms are not well understood. Epilepsy remains a considerable medical mystery, and an outside expert said this revelation could be a productive avenue to pursue, or perhaps not.

The disorder causes a person to have seizures due to a surge of electrical activity affecting parts of the brain. The seizures can manifest in different ways.

Some 60 percent to 70 percent of all people with epilepsy respond well to a single medication, Gross said. Others may respond to a device or surgery.

"We have other means, but we clearly need other medicines and potentially different medicines," Gross said.

Recent research has suggested that activation of the immune system in the brain, and the resulting inflammation processes, may play a role in epilepsy.

These researchers, from the University of Verona in Italy, demonstrated that, in mice, seizures caused "adhesion" molecules in blood vessels in the brain to attach to white blood cells known as leukocytes.

Interrupting this interaction reduced seizures.

Seizures also broke down the blood-brain barrier, which works to keep various molecules out of the brain.

When investigators interfered with the leukocyte-blood vessel binding, the blood-brain "leak" was plugged.

Also, there were more leukocytes present in the brains of people with epilepsy, when compared with healthy individuals. As always with animal models, there is a question about how well the findings extend to apply to humans.

"How generalizable is this?" Gross asked.

More information

Visit the Epilepsy Foundation for more on this condition.



SOURCES: Robert A. Gross, M.D., Ph.D., director, Strong Epilepsy Center, and professor, neurology and pharmacology and physiology, University of Rochester Medical Center, N.Y.; Nov. 23, 2008, Nature Medicine, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Jersey Jury Awards $12.9 Million to Three Patients Whose Use of Roche Acne Medication Accutane Found to Cause Severe Bowel Illness
2. Study identifies causes of bone loss in breast cancer survivors
3. Spinal Anesthesia Doesnt Cause Restless Leg Syndrome
4. Study Suggests Need for More Aggressive Outpatient Monitoring of Patients Hearts When Cause of Stroke is Unclear
5. Mexican Department of Public Health to Launch Screening for Papillomavirus, Cause of Cervical Cancer
6. NLPC Criticizes Obamas Choice of Eric Holder for Attorney General Because of Role in Health Care Task Force Cover-Up
7. Antibiotics can cause pervasive, persistant changes to microbiota in human gut
8. Gulf War research panel finds 1 in 4 veterans suffers from illness caused by toxic exposure
9. Chemical in Plastics May Cause Fertility Problems
10. Caring.com and Alzheimer's Association Use Social Media to Help Spread Awareness for the Nation's Sixth Leading Cause of Death
11. Airport malaria -- cause for concern in the US
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clue to Cause of Epileptic Seizures Discovered
(Date:4/22/2017)... ... 22, 2017 , ... Ecommerce sales have grown every year since the 1990’s, ... The consequences of rapid innovation and growth are often neglected in the name ... every business and individual’s job to give something back to the planet that provides ...
(Date:4/21/2017)... ... April 21, 2017 , ... An April 10 article ... of ancient teeth, which reveal a great deal about prehistoric ice-age dental practitioners and ... may have been used to remove decayed dental matter, and that teeth were then ...
(Date:4/21/2017)... LAKE CITY, Utah (PRWEB) , ... April 21, ... ... provider of wilderness therapy treatment for adolescents and young adults, has kicked off ... April 20th-Sunday, April 23rd. This year’s theme is “Attachment Informed Therapy for ...
(Date:4/21/2017)... ... 2017 , ... The Patient Advocacy Community of The Beryl Institute presented Eve ... Ravich Patient Advocacy Award in recognition of her extraordinary contributions to the field ... at The Beryl Institute’s annual Patient Experience Conference on March 20 in ...
(Date:4/21/2017)... ... April 21, 2017 , ... Alive for Wellness ... wish to overcome their mental health struggles. The Alive team uses advanced behavioral ... “Our approach in dealing with a mental health struggle is based on 10 ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Research ... America Pharmaceutical Contract Manufacturing Services Market Analysis By Service (Manufacturing, ... Segment Forecasts, 2014 - 2025" report to their offering. ... The Latin American ... 21.0 billion by 2025 Low drug registration cost ...
(Date:4/19/2017)... Cardiology devices segment is anticipated to reach the highest market ... segment is likely to create absolute $ opportunity of a ... By the end of 2027, Cardiology Devices segment is projected ... expanding at a CAGR of 18.4% over the forecast period. ... reprocessed medical devices market in terms of revenue ...
(Date:4/19/2017)... April 19, 2017  IRIDEX Corporation (Nasdaq: ... results for the first quarter 2017 after the close ... management team will host a corresponding conference call beginning ... Investors interested in listening to the conference call ... callers or (703) 326-3030 for international callers, using conference ...
Breaking Medicine Technology: