Navigation Links
Club cells are 'bad guys' during flu infection
Date:8/18/2014

A specialized subset of lung cells can shake flu infection, yet they remain stamped with an inflammatory gene signature that wreaks havoc in the lung, according to a study published in The Journal of Experimental Medicine.

Seasonal flu is caused by influenza virus, which can infect a variety of cell types in the lung. Infected cells are typically destroyed by the virus itself or by immune cells that attack infected cells. The resulting inflammation can linger on long after the virus has been eliminated leading to persistent symptoms and, in some cases, severe tissue damage.

Club cells are specialized cells that normally protect against inhaled microbes and pollutants. However, researchers from the Icahn School of Medicine at Mount Sinai in New York show that club cells are bad guys during flu infection. Although they are able to rid themselves of the flu virus, club cells fail to switch off expression of inflammatory genes causing prolonged pathology in the lungs even after the virus has been contained. Depletion of surviving club cells lessened destructive lung damage in flu-infected mice.

The authors confirm that human club cells show a similar inflammatory response to flu infection, so targeting club cells might be a strategy to shorten the duration of flu symptoms in humans.


'/>"/>
Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Researchers identify a mechanism that stops progression of abnormal cells into cancer
2. How breast cancer usurps the powers of mammary stem cells
3. Scientists Inch Closer Toward Using Stem Cells for Spinal Injuries
4. Stem cells show promise for stroke in pilot study
5. Growing human GI cells may lead to personalized treatments
6. Weakness of leukemic stem cells discovered
7. Weakness of leukaemic stem cells discovered
8. Most Cosmetic Procedures Based on Stem Cells Are Bogus, Experts Say
9. Molecular gate that could keep cancer cells locked up
10. Master HSF supports reprogramming of normal cells to enable tumor growth and metastasi
11. A new way to generate insulin-producing cells in Type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Club cells are 'bad guys' during flu infection
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) announced ... Act of 1976, as amended ("HSR"), with respect to ... CPXX ) expired effective June 24, 2016, ... previously announced on May 31, 2016, Jazz Pharmaceuticals and ... Jazz Pharmaceuticals has commenced a tender offer for all ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
Breaking Medicine Technology: