Navigation Links
Clots in Coronary Stents More Likely in Early Morning
Date:2/21/2011

By Amanda Gardner
HealthDay Reporter

MONDAY, Feb. 21 (HealthDay News) -- Prior research has shown that stroke risk peaks in the early morning hours. Now a new study finds that blood clots within stents -- a potential trigger for stroke as well as heart attacks -- also follow a circadian pattern and peak in the early morning.

The authors of the new study also found that this type of blood clot, known as stent thrombosis, was more common in the summer -- unlike heart attacks, which peak during the winter. But stent thrombosis didn't tend to occur on any particular day of the week, whereas heart attacks seem to cluster on Mondays, suggesting that they could be triggered by employment-related stress.

Though rare, blood clots that form after a stent is placed inside an artery to prop it open can lead quickly to a heart attack or death, often even if the patient receives prompt treatment, making efforts to prevent the complication a priority.

And this new study, published in the February issue of JACC: Cardiovascular Interventions, may point to one possible mode of prevention.

"Knowing that [stent thrombosis] may occur early in the morning may suggest that medication wears out by early in the morning," said study senior author Dr. David R. Holmes, Jr., a cardiologist with the Mayo Clinic in Rochester, Minn. "We may need to give medications twice a day to cover that."

While "we can't change the body's circadian rhythms," added Dr. Jacob Shani, chair of the Maimonides Cardiac Institute in New York City, "maybe we can divide the doses of anti-platelet therapy into a dose in the morning and a dose at night."

Generally anti-platelet or clot-busting medication to prevent stent thrombosis is given at night, before the person goes to sleep.

For this study, the authors reviewed records of 124 patients who had arrived at the Mayo Clinic with blood clots within stents between February 1995 and August 2009.

The stent thrombosis events reached a peak at 7 a.m. and a low at 8 p.m. After adjustments, early stent thrombosis still remained significantly associated with the early morning hours.

Blood clots within stents also hit another statistically significant peak in late July/early August. The latter finding suggests that extra activities in the warmer months might contribute to the rise, according to the researchers.

Although potential risk factors documented in some patients, such as heavy physical exertion or medical factors such as surgery, infection and not taking medication correctly, might have triggered some of the blood clots, the data suggested circadian rhythms also played a role, the researchers noted.

A number of factors could explain the rhythms of stent thrombosis, stated the authors. Heart rate, blood pressure and levels of several different hormones have been found to peak in the morning.

"We know that the body basically becomes more hypercoagulable [more likely to clot] in the morning. We know that platelet activity increases in the morning, so all those things together make it more likely for someone to suffer a platelet-mediated event such as a heart attack, stroke or, in this case, stent thrombosis, in the morning," said Dr. Jeffrey Berger, assistant professor of medicine at NYU Langone Medical Center in New York City.

"This may be important in figuring out when somebody should be their taking medicine," he concluded.

More information

The U.S. National Institutes of Health has more about blood clots.

SOURCES: David R. Holmes, Jr., M.D., cardiologist, Mayo Clinic, Rochester, Minn.; Jeffrey Berger, M.D., assistant professor, medicine, NYU Langone Medical Center, New York City; Jacob Shani, M.D., chair, Maimonides Cardiac Institute, New York City; February 2011 JACC: Cardiovascular Interventions


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. Bowel disease link to blood clots
3. Varicose Veins May Put Some at Risk for Dangerous Blood Clots
4. Aspirin Alone Works Best to Prevent Clots a Year After Stenting
5. Patients Who Take a Proton-Pump Inhibitor With Medicine to Prevent Blood Clots Are Less Likely to Be Hospitalized for Bleeding Ulcers
6. In Pregnancy, Leg Clots More Likely on Left Side
7. Prostate Cancer Patients at Higher Risk of Blood Clots
8. Improvement in prediction of blood clots in cancer patients
9. Blood Thinner OK for Superficial Leg Clots: Study
10. New Blood Thinner May Help Fight Dangerous Leg Clots
11. International research team reports major findings in prevention and treatment of blood clots
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clots in Coronary Stents More Likely in Early Morning
(Date:4/28/2017)... Diego, Ca (PRWEB) , ... April 28, 2017 , ... ... property management industry in the coastal communities. After Tina Howe joined the team, the ... and happy employees, honest services at affordable rates, and giving back to the San ...
(Date:4/28/2017)... UTAH (PRWEB) , ... April 28, 2017 , ... ... Account Manager for the North East region. Côté has 20+ years of experience ... Prior to Phytomer, Côté worked with an array of high-end cosmetic brands, retail ...
(Date:4/28/2017)... ... , ... NuevaCare, a leading home care agency based in San Mateo, California, ... proud to announce information upgrades to its blog in the form of WordPress tags. ... such as home care (generally) as well as senior care and home care agency ...
(Date:4/28/2017)... ... ... Christie Medical Holdings, Inc. , with its market-leading vein finder ... a leader in infusion therapy and pain management. , Intravenous (IV) therapy plays ... patients receiving a peripheral IV catheter as part of their treatment plan. Many hospitals ...
(Date:4/27/2017)... Jacksonville, Florida (PRWEB) , ... April 27, 2017 , ... ... qualified candidates. But they will rapidly reject an outdated healthcare executive resume. , “If ... good look at your executive resume and wondering if it’s as ready as you ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 2017 Research and Markets has announced ... Services Market Analysis By Service (Manufacturing, Research), By Country, (Brazil, ... 2025" report to their offering. ... The Latin American pharmaceutical contract manufacturing services ... Low drug registration cost in Latin American countries ...
(Date:4/19/2017)... 2017 The Mobile X-Ray product segment is the ... during the forecast period Mobile X-Ray segment is ... mobile X-Ray devices market, which is estimated to be valued ... a CAGR of 7% over the forecast period. Mobile X-Ray ... than US$ 100 Mn in 2017 over 2016. The segment,s ...
(Date:4/19/2017)... , April 19, 2017 Global Prostate ... report on the prostate cancer therapeutics market analyzes ... market. Increasing prevalence of prostate cancer, launch of ... the development of new drugs & therapeutic biological ... drug due to lesser side effects are some ...
Breaking Medicine Technology: