Navigation Links
Clot-Busting Stroke Drug Safe for Many Who Take Warfarin
Date:6/26/2012

TUESDAY, June 26 (HealthDay News) -- Many patients who've been taking the blood thinner warfarin can safely be administered the powerful clot-busting drug tPA in the event of a stroke, a new study shows.

The findings help ease previous concerns that tPA (tissue plasminogen activator) might be too dangerous to use in stroke patients who had been taking warfarin because it would increase their risk for potentially fatal bleeding in the brain.

Researchers at Duke University's Clinical Research Institute in Durham, N.C., analyzed data from thousands of stroke patients treated with intravenous tPA at more than 1,200 hospitals. While patients who were taking warfarin did have slightly higher rates of intracranial bleeding than those who were not taking warfarin (5.7 vs. 4.6 percent), they also tended to be older, the researchers noted.

So, after the researchers adjusted for age, stroke severity and other factors, they found that the risk of bleeding in the brain was similar for both groups of patients.

The team also found that nearly half of the warfarin-treated patients who might have qualified for potentially lifesaving tPA following a stroke did not receive the clot-busting drug.

The study was published June 26 in the Journal of the American Medical Association.

"To date, we have no randomized trials or large cohort studies to guide us," first author Dr. Ying Xian, an assistant professor of medicine, noted in a Duke news release. "Our large, national study found no statistically significant increase in risk, which supports using intravenous tPA in warfarin-treated patients following stoke if their INR is less than or equal to 1.7."

The INR (International Normalized Ratio) measures the rate at which blood clots while a patient is taking blood thinners such as warfarin, which is prescribed to reduce the risk of stroke in patients with a heart rhythm disorder called atrial fibrillation.

American Heart Association guidelines state that tPA can be used in warfarin-treated patients if their INR is less than or equal to 1.7.

Experts were heartened by the results.

"This should be encouraging for those who treat acute stroke and hesitate when the INR is at all elevated," said Dr. Roger Bonomo, director of stroke care at Lenox Hill Hospital in New York City. "A patient presenting with stroke after taking warfarin is a 'warfarin failure' and deserves another chance at avoiding morbidity [illness/injury]."

Another expert called the research "important" because it provides guidance on when tPA use is safe and appropriate for patients taking warfarin, also known as Coumadin. "Many people take Coumadin who are at high risk of having a stroke, so it is important to know when giving tPA is beneficial to these patients," said Dr. Mark Stecker, chairman of neuroscience at Winthrop University Hospital in Mineola, NY.

More information

The American Heart Association has more about tPA.

-- Robert Preidt

SOURCES: Roger Bonomo, M.D., director, stroke care, Lenox Hill Hospital, New York City; Mark Stecker, M.D., chairman, neuroscience, Winthrop University Hospital, Mineola, N.Y.; Duke University, news release, June 26, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Predictors identified for rehospitalization among post-acute stroke patients
2. Could Menthol Cigarettes Pose Even Higher Stroke Risk?
3. NJ stroke researchers report advances in spatial neglect research at AAN Conference
4. Mobile Stroke Units Might Trim Time to Treatment
5. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
6. Stopping Blood Thinners Raises Stroke Risk for Patients With Irregular Heartbeat
7. Cedars-Sinai stroke team earns award for improving regions quality of care
8. Procedure gives patients with A-fib who cant take blood thinners alternative to reduce stroke
9. Irregular Heartbeat Poses Greater Stroke Risk for Women Than Men
10. Elderly women with irregular heart beat at higher risk for stroke
11. Rate of Hospitalizations for Stroke Has Declined in U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clot-Busting Stroke Drug Safe for Many Who Take Warfarin
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... MD (PRWEB) , ... October 12, 2017 , ... The ... of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual ... – 8. , In honor of Morris F. Collen, a pioneer in the field ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra ... care advancements to physician colleagues, skilled nursing facility medical directors and other clinicians ... Waters of Wound Care." , "At many of these conferences we get to ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, ... more than $100 billion in purchasing power, today announced ... and information. The Newsroom is the online ... industry trends, infographics, expert bios, news releases, slideshows and ... access to a wealth of resources at their fingertips, ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
Breaking Medicine Technology: