Navigation Links
Clot-Busting Stroke Drug Safe for Many Who Take Warfarin
Date:6/26/2012

TUESDAY, June 26 (HealthDay News) -- Many patients who've been taking the blood thinner warfarin can safely be administered the powerful clot-busting drug tPA in the event of a stroke, a new study shows.

The findings help ease previous concerns that tPA (tissue plasminogen activator) might be too dangerous to use in stroke patients who had been taking warfarin because it would increase their risk for potentially fatal bleeding in the brain.

Researchers at Duke University's Clinical Research Institute in Durham, N.C., analyzed data from thousands of stroke patients treated with intravenous tPA at more than 1,200 hospitals. While patients who were taking warfarin did have slightly higher rates of intracranial bleeding than those who were not taking warfarin (5.7 vs. 4.6 percent), they also tended to be older, the researchers noted.

So, after the researchers adjusted for age, stroke severity and other factors, they found that the risk of bleeding in the brain was similar for both groups of patients.

The team also found that nearly half of the warfarin-treated patients who might have qualified for potentially lifesaving tPA following a stroke did not receive the clot-busting drug.

The study was published June 26 in the Journal of the American Medical Association.

"To date, we have no randomized trials or large cohort studies to guide us," first author Dr. Ying Xian, an assistant professor of medicine, noted in a Duke news release. "Our large, national study found no statistically significant increase in risk, which supports using intravenous tPA in warfarin-treated patients following stoke if their INR is less than or equal to 1.7."

The INR (International Normalized Ratio) measures the rate at which blood clots while a patient is taking blood thinners such as warfarin, which is prescribed to reduce the risk of stroke in patients with a heart rhythm disorder called atrial fibrillation.

American Heart Association guidelines state that tPA can be used in warfarin-treated patients if their INR is less than or equal to 1.7.

Experts were heartened by the results.

"This should be encouraging for those who treat acute stroke and hesitate when the INR is at all elevated," said Dr. Roger Bonomo, director of stroke care at Lenox Hill Hospital in New York City. "A patient presenting with stroke after taking warfarin is a 'warfarin failure' and deserves another chance at avoiding morbidity [illness/injury]."

Another expert called the research "important" because it provides guidance on when tPA use is safe and appropriate for patients taking warfarin, also known as Coumadin. "Many people take Coumadin who are at high risk of having a stroke, so it is important to know when giving tPA is beneficial to these patients," said Dr. Mark Stecker, chairman of neuroscience at Winthrop University Hospital in Mineola, NY.

More information

The American Heart Association has more about tPA.

-- Robert Preidt

SOURCES: Roger Bonomo, M.D., director, stroke care, Lenox Hill Hospital, New York City; Mark Stecker, M.D., chairman, neuroscience, Winthrop University Hospital, Mineola, N.Y.; Duke University, news release, June 26, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Predictors identified for rehospitalization among post-acute stroke patients
2. Could Menthol Cigarettes Pose Even Higher Stroke Risk?
3. NJ stroke researchers report advances in spatial neglect research at AAN Conference
4. Mobile Stroke Units Might Trim Time to Treatment
5. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
6. Stopping Blood Thinners Raises Stroke Risk for Patients With Irregular Heartbeat
7. Cedars-Sinai stroke team earns award for improving regions quality of care
8. Procedure gives patients with A-fib who cant take blood thinners alternative to reduce stroke
9. Irregular Heartbeat Poses Greater Stroke Risk for Women Than Men
10. Elderly women with irregular heart beat at higher risk for stroke
11. Rate of Hospitalizations for Stroke Has Declined in U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clot-Busting Stroke Drug Safe for Many Who Take Warfarin
(Date:5/26/2016)... , ... May 26, 2016 , ... ... intellectual property (IP) to its specialty academic programs. , Answering to the increasing ... existing certificate programs in health law, and environmental and land use law. , ...
(Date:5/26/2016)... ... 2016 , ... Cardiac arrhythmia is a common complication following ... survival, reports a team of UPMC researchers in the largest study of its ... Thoracic and Cardiovascular Surgery, provide critical information that will hopefully lead to better ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James Maisel will ... Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the Farmingdale Public ... Retina Group of New York , is a Board Certified ophthalmologist who ...
(Date:5/26/2016)... ... 2016 , ... Leadership of Life Science Logistics (LSL), a ... earned its ISO 13485 certification, indicating the company’s quality control system for medical ... associated with ISO quality standard 13485. , BSI Group America, Inc., a ...
(Date:5/26/2016)... ... May 26, 2016 , ... Nike Yoga Camps ... from daily practices, arts & crafts, discussions, and games all geared towards enhancing ... Evans have combined backgrounds in kids’ yoga, collegiate sport yoga instruction, and global ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25,2016 FDA ... near-infrared Cellvizio platform for urological and surgical applications ... MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser ... milestone in the US with the 12 th ... Drug Administration (FDA). This new FDA clearance covers ...
(Date:5/25/2016)... , Germany and GERMANTOWN, ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... licensing and co-development agreement with Therawis Diagnostics GmbH to develop ... be to develop and market PITX2 as a marker to ... high-risk breast cancer patients. "We are pleased to ...
(Date:5/25/2016)... -- According to market research "Global Insulin ... Forecast to 2022 - Industry Insights by Type (Insulin ... P&S Market Research, the global insulin delivery device market ... is expected to grow at a CAGR of 6.6% ... is expected to witness the fastest growth at a ...
Breaking Medicine Technology: