Navigation Links
Clot-Busting Drug May Work for Those Who Have Strokes While Asleep
Date:2/1/2012

By Denise Mann
HealthDay Reporter

WEDNESDAY, Feb. 1 (HealthDay News) -- New research suggests that it may be safe to give the clot-busting drug tPA to people who wake up with stroke symptoms, even though there is a short time window in which to use the treatment and doctors have no idea when these patients first started experiencing their stroke.

The powerful medication can save lives and stave off lasting disability after a stroke, but experts believe it needs to be given within 4.5 hours of the start of symptoms. Almost 25 percent of people who have strokes have them while they are asleep, the study authors noted, and doctors typically err on the side of caution, assume the stroke happened when the patient first went to bed and do not treat with tPA.

However, in this latest study, doctors from King's College Hospital in London used a stroke registry to compare 326 patients treated with tPA within 4.5 hours of symptoms to 68 "wake-up" stroke patients. The second group only received clot-busting drugs if they had similar symptoms and showed the same signs of early stroke-related brain changes on CT scans that people whose strokes occurred within the 4.5-hour window did. The risks, namely bleeding, of giving tPA outside of this window are thought to outweigh its benefits.

In the study, the death rates, risk of bleeding inside the brain and recovery rates after three months were similar in both groups of stroke patients.

"Our study shows that administering clot-busting drugs to patients with wake-up stroke who have the same clinical and imaging features as those treated within current guidelines is feasible and safe," study author Dr. Dulka Manawadu, a medical consultant at King's College Hospital, said in a news release, although he added that more research is needed to confirm the findings.

The study was slated to be presented Wednesday at the American Stroke Association meeting in New Orleans. Research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed medical journal.

Of the similar findings between groups,"it is encouraging and it doesn't yet prove that they will get the same benefits, but it doesn't seem that the risk is excessive," said Dr. Steven Greenberg, vice chairman of the International Stroke Conference 2012's program committee and a professor of neurology at Harvard Medical School. "Even if only a subset of wake-up stroke patients were eligible for tPA, it is still a subset of a substantially large number, so the importance is pretty high."

The bottom line remains unchanged, he said: "If you or someone you know is having a stroke, call 911 or get to an emergency room as fast as possible. The earlier treatment is started within the 4.5-hour window, the better. With every minute that goes by, you lose part of the benefit and gain more risk."

"A large number of patients can't receive tPA is because they are too far past the window of opportunity," added Dr. M. Shazam Hussain, a neurologist at the Cleveland Clinic, in Ohio. Most "wake-up" strokes do occur close to when a person wakes up, he noted, so "potentially this will expand treatment quite significantly."

"A lot of people are denied treatment because there is no exact time of onset, because the risks may outweigh the benefits of tPA," he said. "I want to see a larger study done, but it certainly lends weight to help advocate for expanded use of tPA among wake-up stroke patients."

More information

Find out about stroke warning signs at the American Stroke Association.

SOURCES: M. Shazam Hussain, M.D., neurologist, Cleveland Clinic, Ohio; Steven Greenberg, M.D., Ph.D., professor, neurology, Harvard Medical School, Boston; Feb. 1, 2012, presentation, American Stroke Association meeting, New Orleans


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. More Neurology Residents Using Clot-Busting Drug for Stroke
2. Use of clot-busting drug for US stroke patients doubled from 2005 to 2009
3. More Stroke Patients Get Clot-Busting Drug But Barriers Remain
4. How well does clot-busting drug work in stroke patients?
5. Longer Time Frame for Clot-Busting Drug May Help Beat Stroke
6. Early Treatment With Clot-Busting Drug Best After Stroke
7. Knee replacement surgery incidence soars in those over age 50
8. Alzheimers Med Seems Ineffective in Those With Down Syndrome
9. Exercise May Help Those at Higher Risk for Alzheimers: Study
10. For those with diabetes, controlling blood pressure is crucial, but not urgent
11. Flu Prevention Critical for Those With Neurologic Conditions, CDC Says
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clot-Busting Drug May Work for Those Who Have Strokes While Asleep
(Date:3/23/2017)... ... ... Journey Through Heaven”: the true-life account of a man who faced death and emerged ... for His people. “My Journey Through Heaven” is the creation of published author Earl ... grandchildren living and doing for God as best they can. , Published by Christian ...
(Date:3/23/2017)... ... 2017 , ... “More Corruption”: a simple and strong explanation of the God’s love. “More ... of Heaven was asked by God to write a book about Him. , She says, ... I kept my commitment to the Lord God. They have not walked in my shoes ...
(Date:3/22/2017)... ... March 23, 2017 , ... Catalent Pharma Solutions, ... biologics and consumer health products, today announced that it had won the ‘Clinical ... at the Suntec Singapore International Exhibition & Convention Centre, Singapore. The award was ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... Old School ... boxing champ Ashley Theophane as a new Brand Ambassador. Theophane, who trained with Floyd ... welterweight title in 2011. He has racked up an impressive number of wins in ...
(Date:3/22/2017)... ... 22, 2017 , ... Wash Tower Ltd. has released a series of six ... the world's first standalone constant pressure bidet. , The videos in the series titled ... https://www.washtower.com as well as on its social media pages. , Each video stars ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... -- DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... solutions, today reported financial and operational results for ... 31, 2016. 2016 Highlights ... compared to the full year 2015  ... year  Direct-to-consumer model launched in ...
(Date:3/22/2017)... today announced the appointment of Martyn Coombs as Chief ... ImaginAb, said "At ImaginAb we have exciting science and technology. Martyn ... business, particularly in commercializing and making step changes in the value ... our potential." ... Coombs is a recognized industry leader in nuclear medicine and imaging. ...
(Date:3/22/2017)... -- Ablation is the minimally invasive therapeutic tissue excision ... from cancerous or diseased tissue removal, to the ... fibrillation and others. The growing adoption of minimally ... and improvise existing ablation technologies for better patient ... is expected to grow at high single digit ...
Breaking Medicine Technology: