Navigation Links
Closing in on an ulcer- and cancer-causing bacterium
Date:12/7/2011

ist within the acid bath in the human stomach that has made it such a successful, albeit harmful, vector, says Fong. "The key is its use of an enzyme called urease to neutralize gastric acid," he explains.

H. pylori produce urease to spur the breakdown of urea, a naturally occurring chemical in the body, so that urea can release ammonia and make the gut an environment in which the pathogens can thrive. But, unlike most other enzymes, urease doesn't start doing its job immediately after being produced by the bacterium; instead, two nickel ions have to be delivered to it, and then the enzyme can mature, so to speak, and thus allow H. pylori to begin their damaging work.

"As the survival of H. pylori depends on active urease, this is a life-or-death issue for the pathogen to ensure nickel ions are delivered to the urease," says Kam-Bo Wong, a professor who oversaw the project at the institution.

It's not entirely clear how H. pylori make sure that urease can mature and then neutralize the surrounding acid. But Wong's team focused on four proteins that they suspect are helpers: UreE, UreF, UreG and UreH.

Using X-ray crystallography, "which essentially performs the function of a molecular microscope to visualize proteins with atomic resolution," Fong explains, the team took snapshots of UreF and UreH. What they saw was that UreH morphs the shape of UreF to enable UreF to recruit a third player, UreG, to form the UreF-UreH-UreG complex. In other words, the three proteins hook up to collectively deliver nickel ions to the right place on urease. Once the nickel ions are in place, they serve like a flint to ignite the breakdown of urea into ammonia, which then neutralizes the stomach acids.

"So, now we have a better understanding of how the machine can assemble itself, as if a skillful mechanic were there for the job, and deliver the nickel ions," says Fong.

Importantly, the team also discovered
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
240-283-6614
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Fear of Antidepressants Keep Many From Disclosing Depression
2. Closing Schools Seems to Prevent Flus Spread
3. U.S. Nursing Home Closings Hit Poor Neighborhoods Hardest: Study
4. 1 in 5 Parents Missed Work for H1N1 School Closings: Survey
5. Closing the science-to-policy gap in maternal and child health in Africa
6. Labopharm announces closing of US$20 million public offering of units
7. Team discovers how a cancer-causing bacterium spurs cell death
8. New study finds cancer-causing mineral in US road gravel
9. NYU researchers develop compound to block signaling of cancer-causing protein
10. Hebrew University researchers discover expanded role for cancer-causing gene
11. Study finds that cancer-causing gene crucial in stem cell development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Closing in on an ulcer- and cancer-causing bacterium
(Date:12/22/2014)... 2014 Coral Gables is preparing to welcome ... Troopers, with its new clinic location set to open in ... hassle out of dealing with this common childhood parasite by ... two salon clinic locations in South Florida, or in the ... decision to expand developed naturally out of the demand for ...
(Date:12/22/2014)... New York (PRWEB) December 22, 2014 The ... a staple of the season. Many may be thinking about ... a span of a few weeks. Health Republic Insurance of ... of Registered Dietitian, Andrea Chernus, to provide some smart ideas ... and stay healthy. , 1)    Avoid arriving at a holiday gathering ...
(Date:12/22/2014)... Shanghai, China (PRWEB) December 22, 2014 ... for MabThera (rituximab) for the treatment of non-Hodgkin’s lymphoma ... Health , a leading global healthcare consulting firm. MabThera ... B-cell lymphoma (DLBCL), the most common form of NHL. ... Market Access and Barriers,” the incidence of NHL in ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Only weeks ... southern and mid-western cities to have a battery manufacturer ... TalkLocal ( http://www.talklocal.com ) is launching in Henderson ... economy. , “A strong manufacturing sector is going ... founder Gurpreet Singh explained, “and TalkLocal works with small ...
(Date:12/22/2014)... 2014 Pasadena sleep apnea ... sleep apnea. Drowsy drivers are 15 times more likely ... well-rested, and some experts believe that sleep-deprived drivers may ... drivers. Unfortunately, millions of Americans may be sleep-deprived without ... Sleep Medicine, about 18 million Americans have sleep apnea, ...
Breaking Medicine News(10 mins):Health News:Professional In-Home All-Natural Lice Removal Service Expands to Coral Gables and surrounding areas. 2Health News:Health Republic Insurance of New York Offers Five Simple Tips to Eat Healthy During the Holidays 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2
... offers 50 percent smaller size, 20 percent less ... in portable equipment, DALLAS, March 24 ... market, Texas Instruments (TI) (NYSE: TXN ),today ... ends (AFEs) for,portable to high-end ultrasound diagnostic equipment. ...
... Medicare & Medicaid Services Accepts as Complete DNV,s ... Application for Hospital Deeming Authority, HOUSTON, March ... has informed DNV Healthcare that its application to,deem hospitals in ... complete and ready for formal review., If approved, DNV ...
... and vision care with ... medical coverage, DETROIT, March ... all rolled into one product package., The "package" is Community Blue ... that will launch April 1. Community,Blue Plus combines preventive dental and vision ...
... Health care facilities, like all,Pennsylvania businesses, strive ... reducing workers, compensation expenses driven by claims made,against ... challenges,in the frequency and types of on the ... based law firm of Fried, Kane, Walters, Zuschlag,and ...
... and dementia patients and ... families regain what was once ... million Americans,including 250,000 Ohioans, struggle with the devastating effects ... the greater,Cleveland area offers new hope to Alzheimer,s patients ...
... -- Sinovac Biotech Ltd. (Amex:,SVA), a leading provider of ... Ms. Nan Wang, Vice President, Ms. Helen Yang,International Business ... at the Brean Murray, Carret & Co. Fourth Investor ... p.m. China Standard Time at the,Grand Hyatt Hotel in ...
Cached Medicine News:Health News:Video: TI unveils industry's first family of complete analog front ends for superior ultrasound systems 2Health News:Video: TI unveils industry's first family of complete analog front ends for superior ultrasound systems 3Health News:Video: TI unveils industry's first family of complete analog front ends for superior ultrasound systems 4Health News:DNV Healthcare Advances in Bid to Accredit Hospitals 2Health News:Blue Cross Blue Shield of Michigan Pioneers 'Total Body' PPO Product 2Health News:Reducing Cost of Health Care by Addressing Workers' Compensation Costs 2Health News:Cleveland Area Homewatch CareGivers Unveil New Alzheimer's Program 2Health News:Sinovac to Present at the Brean Murray, Carret & Co. Fourth Investor Tour of China 2
(Date:12/19/2014)... Dec. 18, 2014  Sage Analytics ( www.sageanalytics.com ... equipment for the testing of marijuana potency and ... new Luminary™ Profiler, the industry,s first product suite ... a cost-effective, portable unit. Designed from ... of the cannabis industry, the Luminary™ Profiler utilizes ...
(Date:12/19/2014)... Calif., Dec. 18, 2014 Capnia, Inc. ... development of medical diagnostics based on its proprietary ... flow, today announced financial results for the third ... "Following the completion of our initial ... to maximize the recently initiated CoSense® commercial launch," ...
(Date:12/19/2014)... , Dec. 18, 2014 Baptist Health Lexington is ... to receive full Atrial Fibrillation with Electrophysiology Services (EPS) ... Atrial fibrillation is the most common cardiac arrhythmia ... some cases can lead to stroke and possible death. More ... have atrial fibrillation and the numbers are rapidly ...
Breaking Medicine Technology:Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3
... Loss, Non-Inferiority in Target Vessel Failure and Low Rates of MACE ... ... PARK, Ill., April 22 A study published,in today,s Journal of ... Everolimus Eluting Coronary Stent System,in patients with coronary artery disease resulted ...
... Data For Presentation At ASCO 2008, LONDON ... a wide range of new data at the ... Chicago starting Friday, May,30th. The data cover a ... treatment and supportive care of cancer,patients. At this ...
Cached Medicine Technology:Study in JAMA Shows Patients Treated With Abbott's XIENCE(TM) V Drug Eluting Stent Experience Better Outcomes Than Patients Treated With Market-Leading Drug Eluting Stent 2Study in JAMA Shows Patients Treated With Abbott's XIENCE(TM) V Drug Eluting Stent Experience Better Outcomes Than Patients Treated With Market-Leading Drug Eluting Stent 3Study in JAMA Shows Patients Treated With Abbott's XIENCE(TM) V Drug Eluting Stent Experience Better Outcomes Than Patients Treated With Market-Leading Drug Eluting Stent 4Study in JAMA Shows Patients Treated With Abbott's XIENCE(TM) V Drug Eluting Stent Experience Better Outcomes Than Patients Treated With Market-Leading Drug Eluting Stent 5GlaxoSmithKline Reports Further Progress of Oncology Portfolio 2GlaxoSmithKline Reports Further Progress of Oncology Portfolio 3GlaxoSmithKline Reports Further Progress of Oncology Portfolio 4GlaxoSmithKline Reports Further Progress of Oncology Portfolio 5GlaxoSmithKline Reports Further Progress of Oncology Portfolio 6GlaxoSmithKline Reports Further Progress of Oncology Portfolio 7
Inquire...
Inquire...
... X-22 Series is up to 10 inches/ 25 cm ... 11 rotors, the Allegra X-22 Series is the space-saving ... Only 18 inches / 46 cm wide • 11 ... 3 different ways to Spin 1.5 mL & ...
... Optimal for Subcellular Fractionation, Proteins ... g (30,000 rpm) with fixed-angle ... 0.25 up to 85 mL ... C to 40° C • ...
Medicine Products: