Navigation Links
Clinicians urged to consider spironolactone in HFPEF despite TOPCAT results
Date:5/18/2014

Athens, 18 May 2014: Clinicians have been urged to consider using spironolactone in their patients with heart failure and preserved ejection fraction (HFPEF) after a post-hoc analysis of the TOPCAT trial showed benefit in patients from the Americas.

The research was presented today at the Heart Failure Congress 2014 in Athens, Greece. The Congress is the main annual meeting of the Heart Failure Association of the European Society of Cardiology.

Professor Bertram Pitt said: "We've had many studies showing that ACE inhibitors, angiotensin receptor blockers, beta blockers and mineralocorticoid receptor blockers reduce mortality and hospitalisations in patients with heart failure and reduced ejection fraction (HFREF). But no studies have found a benefit of these medications in HFPEF patients."

He added: "The results of TOPCAT are complicated. The trial failed to meet its primary endpoint but post-hoc analysis has shown that spironolactone was beneficial in patients from the Americas. I think individual clinicians around the world need to look at the data and decide for themselves. If I was a clinician I would use spironolactone in my patients with HFPEF."

TOPCAT randomised 3445 patients with HFPEF to receive spironolactone, a mineralocorticoid receptor antagonist, at a dose of 15-45mg per day or placebo on top of usual care. Patients were recruited from 270 medical centres in 6 countries. Nearly half of the patients were from Russia and Georgia, and the remainder were from the Americas which included Canada, the US, Argentina and Brazil.

After a mean follow up of 3.3 years, the primary endpoint - which was a composite of reduction in cardiovascular mortality, resuscitated cardiac arrest and hospitalisation for heart failure - was reduced but was not reduced significantly.1 It occurred in 320 of 1722 patients
'/>"/>

Contact: ESC Press Office
press@escardio.org
33-622-834-576
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New study suggests clinicians overlook alcohol problems if patients are not intoxicated
2. Disorders of consciousness: How should clinicians respond to new therapeutic interventions?
3. New tool for clinicians proves effective predictor of lung cancer risk
4. When clinicians and researchers look outside the box
5. Survey of clinicians: User satisfaction with electronic health records has decreased since 2010
6. AMD Global Telemedicine Increases Data Sharing Capabilities for Clinicians and Physicians with AGNES 3.1.0
7. AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards
8. Clinicians often wait for red flags before discussing elderly driving
9. Nineteen Clinicians Receive Advanced Certifications at BenchMark Physical Therapy
10. Astronaut Story Musgrave, MD, to Deliver a Keynote Address at Pri-Med East Conference & Exhibition for Primary Care Clinicians
11. Is clinicians decision making affected by precious baby phenomenon?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Liberty University has received accreditation for ... from the Council for Accreditation of Counseling & Related ... Center for Counseling & Family Studies , is under ... university’s new School of Behavioral Sciences. Prior to the formation ...
(Date:1/22/2015)... Chemo Duck Program is pleased to announce the release of the ... with cancer. The Chemo Duck App, available on iTunes for use ... to help children of all ages living with cancer adjust to ... entertained, educated and at ease while waiting for clinic visits or ...
(Date:1/22/2015)... is a famous wedding dress company offering many trendy designs. ... Facebook, Twitter, and Pinterest. The fans will have an opportunity ... every week. , Moreover, the company has extended its 2015 ... homepage for more information. , Angelweddingdress is a ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2
... and an affordable follow-up test to identify children with ... first chemotherapy regimen, // has been developed by researchers ... have a good response may then be treated by ... ,This new test is based on testing ...
... center in Houston stated yesterday that ultrasound is fast becoming ... pregnant woman. // ,Dr. Wei Yang of ... to educate young women that the symptomatic breast cancer that ... pregnant, and so they should not wait to seek medical ...
... on a study to gauge if exercise can prevent ... after chemotherapy.// The study is being funded by a ... Armstrong. ,Charles Matthews, Ph.D., and Laurel Brown, ... lead a team of researchers at Vanderbilt-Ingram as they ...
... from the University of Alabama, Birmingham, told a jury at ... no significant difference in the rate of heart attacks //among ... drug Vioxx is produced and marketed by Merck & Co.'s. ... that the studies, covering a total of about 28,000 patients, ...
... that snake venom can be used for easing the debilitating ... development manager at the Shulov Institute of Sciences (SIS) in ... an analgesic based on snake venom could be on sale ... Palestinian viper - the most common snake in Israel - ...
... of an ambitious public-private initiative for the establishment of ... health professionals. // This announcement seeks to address the ... sections of the society. ,The new venture ... aims to impart multi-disciplinary knowledge through a network of ...
Cached Medicine News:Health News:Inexpensive ALL Follow-Up Test Developed By St. Jude Researchers 2Health News:Inexpensive ALL Follow-Up Test Developed By St. Jude Researchers 3Health News:Could Long Tern Vioxx Users Suffer From Heart Attacks? 2
(Date:1/23/2015)... than a third of reproductive-aged women enrolled in Medicaid, and ... a prescription for an opioid pain medication each year during ... Mortality Weekly Report (MMWR). Opioids are typically ... pain.  They are also found in some prescription cough medications. ...
(Date:1/23/2015)... Idaho , Jan. 23, 2015  Now available for ... No. 7,849,611) support that prevents ankle sprains by cushioning ... brace, it fits securely around the outside of any ... mobility & comfort while still offering protection against sprains. ...
(Date:1/23/2015)... Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: CTSO), ... extracorporeal cytokine adsorber to reduce deadly inflammation in ... of $385,642, net of transaction costs, in non-dilutive ... Business Tax Certificate Transfer Program sponsored by the ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... DALLAS, April 5, 2012 The " ... Opportunities & Global Forecasts to 2016 " analyzes ... Americas, Europe, Asia, and Rest of the World. ...   " Home Healthcare Market ...
... Pharma, a Boston based pharmaceutical company presented novel data ... at the 103rd Annual AACR meeting.  The company had ... dealt with endothelial cell biology relative to tumor angiogenesis, ... therapy, synergy of BPM 31510, Berg,s lead oncology drug ...
Cached Medicine Technology:MarketsandMarkets: Global Home Healthcare Market Worth $296 Billion by 2016 2MarketsandMarkets: Global Home Healthcare Market Worth $296 Billion by 2016 3Berg Pharma Presents Key Findings in Cancer Systems Biology and Mitochondrial Metabolism at AACR Meeting 2Berg Pharma Presents Key Findings in Cancer Systems Biology and Mitochondrial Metabolism at AACR Meeting 3
... Mesh is a monofilament, ... the central section with ... of porcine collagen. The ... Avaulta™ BioSynthetic Mesh are ...
Comprised of a monofilament polypropylene mesh coated with hydrophilic porcine collagen, Pelvitex™ mesh is clinically proven coating to enhance the healing process, along with the strength and d...
... is a soft monofilament ... be used for a ... procedures, including cystocele, rectocele, ... yet strong, POPmeshs flexibility ...
... XM is a biological material ... material known for excellent suppleness ... manufacturing procedures ensure high levels ... patented processing enhances the biocompatibility, ...
Medicine Products: