Navigation Links
Clinicians urged to consider spironolactone in HFPEF despite TOPCAT results
Date:5/18/2014

Athens, 18 May 2014: Clinicians have been urged to consider using spironolactone in their patients with heart failure and preserved ejection fraction (HFPEF) after a post-hoc analysis of the TOPCAT trial showed benefit in patients from the Americas.

The research was presented today at the Heart Failure Congress 2014 in Athens, Greece. The Congress is the main annual meeting of the Heart Failure Association of the European Society of Cardiology.

Professor Bertram Pitt said: "We've had many studies showing that ACE inhibitors, angiotensin receptor blockers, beta blockers and mineralocorticoid receptor blockers reduce mortality and hospitalisations in patients with heart failure and reduced ejection fraction (HFREF). But no studies have found a benefit of these medications in HFPEF patients."

He added: "The results of TOPCAT are complicated. The trial failed to meet its primary endpoint but post-hoc analysis has shown that spironolactone was beneficial in patients from the Americas. I think individual clinicians around the world need to look at the data and decide for themselves. If I was a clinician I would use spironolactone in my patients with HFPEF."

TOPCAT randomised 3445 patients with HFPEF to receive spironolactone, a mineralocorticoid receptor antagonist, at a dose of 15-45mg per day or placebo on top of usual care. Patients were recruited from 270 medical centres in 6 countries. Nearly half of the patients were from Russia and Georgia, and the remainder were from the Americas which included Canada, the US, Argentina and Brazil.

After a mean follow up of 3.3 years, the primary endpoint - which was a composite of reduction in cardiovascular mortality, resuscitated cardiac arrest and hospitalisation for heart failure - was reduced but was not reduced significantly.1 It occurred in 320 of 1722 patients
'/>"/>

Contact: ESC Press Office
press@escardio.org
33-622-834-576
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New study suggests clinicians overlook alcohol problems if patients are not intoxicated
2. Disorders of consciousness: How should clinicians respond to new therapeutic interventions?
3. New tool for clinicians proves effective predictor of lung cancer risk
4. When clinicians and researchers look outside the box
5. Survey of clinicians: User satisfaction with electronic health records has decreased since 2010
6. AMD Global Telemedicine Increases Data Sharing Capabilities for Clinicians and Physicians with AGNES 3.1.0
7. AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards
8. Clinicians often wait for red flags before discussing elderly driving
9. Nineteen Clinicians Receive Advanced Certifications at BenchMark Physical Therapy
10. Astronaut Story Musgrave, MD, to Deliver a Keynote Address at Pri-Med East Conference & Exhibition for Primary Care Clinicians
11. Is clinicians decision making affected by precious baby phenomenon?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, iFitDress.com, the ... for women, has announced its new selection of black ... are on sale now; they are available at discounted prices, ... says, “The promotion will last for three weeks only. You ... market. Those who are interested in our new items can ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 The short film ... was created in honor of a true 9/11 hero, Welles ... film festivals including the 24 hours of Nuremberg International Short ... Bangladesh. , Actress, screenwriter and director Luciana Lagana ... this film together with her husband, Gregory Graham ...
(Date:12/25/2014)... BambooFlooringChina.com sells many bamboo products and the business ... company announces big discounts on its bamboo mats ... BambooFlooringChina.com is the world’s leader in bamboo flooring. According ... Jan. 20, 2015. , The bamboo mats are made ... thread. All the bamboo strips for the mats are ...
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... Plan focuses on added benefits to improve care ... with chronic health conditions -, LITTLE ROCK, ... Medicare annual enrollment period which begins November 15th, ... 2009 Special Needs Plan,(SNP) offerings for chronically ill ...
... Points to Need for a Federal Office of Men,s ... national,phone and direct mail effort, was administered to the ... Washington, D.C.) and,the Governor,s Office, where appropriate. The survey ... Meeting in San,Diego on October 26th, 2008 and are ...
... of the National Organization for Rare Disorders ... Compassionate Allowances,initiative "an outstanding achievement" that will ... The initiative announced today will fast-track applications ... of 25 rare diseases and 25,cancers whose ...
... NANJING, China, Oct. 27 /Xinhua-PRNewswire/ -- Simcere ... manufacturer and supplier of branded generic,pharmaceuticals and ... market, announced today its participation in the ... conference will be,held at the Grand Hyatt ...
... led by UBC Psychiatry Prof. Weihong Song, who is also ... Disease at UBC, found that if Valproic Acid (VPA) is ... deficit is reversed. , The study, published in the Journal ... activity of an enzyme that produces a neurotoxic protein called ...
... Readers to Meaningful Coincidences, LOUISVILLE, Colo., Oct. ... Clearly Now: How Synchronicity Illuminates Our,Lives, has been ... in both Best New,Non-Fiction and Best New Age ... USABookNews.com, the premiere online magazine and review ...
Cached Medicine News:Health News:Care Improvement Plus Launches 2009 Benefits in Arkansas 2Health News:New State Public Health Department Survey Results Highlight Available Resources for Men and Women 2Health News:New Compassionate Allowances for Social Security Disability Represent 'Outstanding Achievement,' NORD Says 2Health News:Simcere Pharmaceutical Group to Participate in Goldman Sachs China Investment Frontier Conference 2008 2Health News:New Author Mary Soliel Honored as Two-time National Best Books 2008 Award Finalist 2
(Date:12/24/2014)... , Dec. 23, 2014   Assurex Health, ... support to healthcare providers for behavioral health and ... secured $30 million in equity financing from new ... Drosos , President and Chief Executive Officer. ... and development of Assurex Health,s GeneSight ® ...
(Date:12/24/2014)... , Dec. 23, 2014 Tianyin ... company that specializes in patented biopharmaceutical, modernized traditional ... ingredients (API) today announced that the Company achieved ... Good Manufacturing Practice (GMP) certificate of TPI,s Qionglai ... Administration,s (CFDA). The public notice period is a ...
(Date:12/24/2014)...  Medical Science Liaisons play a large role in ... medical device industry and key stakeholders, the role of ... as the device industry relies on them to build ... benchmarking firm, Best Practices, LLC, one area where Medical ... by harnessing new technology to enable education. Online conferences ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... 21, 2010 Reportlinker.com announces that a new ... Thai Self-monitoring of Blood Glucose ... http://www.reportlinker.com/p0350305/Thai-Self-monitoring-of-Blood-Glucose-SMBG-Devices-and-Strips-Market.html This Market Engineering ... dynamics of blood glucose monitoring device sales and ...
... 2010 The American Veterinary Medical Association (AVMA) has offered ... on a useful and effective induction agent, propofol. ... Schedule IV drug.  In a letter to the DEA today, ... this effective drug, which typically causes few side effects when ...
Cached Medicine Technology:AVMA Offers Important Guidance to DEA on New Controls for Induction Agent—Propofol 2
... The OcuLight family of infrared laser photocoagulators ... models. These diode lasers serve as a ... and applications, require no regular maintenance or ... their compact design. The OcuLight SLx is ...
... Using the latest in solid-state technology, ... green light at 532 nm. Patented ... delivery device options maximize versatility, compact ... and advanced design minimizes any routine ...
... Danker Laboratories manufacturers a ... orthokeratology lenses (also known ... "Corneal Reshaping" Lenses) according ... and demanding standards of ...
... The Euclid Systems Orthokeratology (oprifocon A) ... contact lenses used for orthokeratology, a ... The patient wears these lenses overnight ... During the day, nearsightedness is temporarily ...
Medicine Products: