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Clinical trials for new Alzheimer's disease treatment to be awarded European Commission €6m funding
Date:5/25/2011

s of AD and other dementias amount to more than 440,000 million each year (www.alz.org, 2010). It is estimated that by 2050, 1 in 85 of the population worldwide will have AD. There are few effective symptomatic treatments and as of the moment, no treatment that can delay or prevent Alzheimer's disease.

Treating high blood pressure with medications like NILVADIPINE have been shown to decrease the risk of developing dementia and Alzheimer's disease. In partnership with The Roskamp Institute in Florida, which developed the basic science evidence for the potential effectiveness of NILVADIPINE, Mercer's Institute for Successful Ageing at St James's Hospital, Dublin, conducted an earlier safety study also led by Professor Lawlor, on Alzheimer's disease patients that formed the basis for this new clinical trial. Now, in collaboration with key partners* and Alzheimer's disease experts, NILVAD will conduct these multi-centre European trials. The trials will determine if NILVADIPINE can improve memory and functioning but also slow the rate of progression of Alzheimer's disease. In preclinical studies NILVADIPINE lowers brain levels of amyloid which is thought to contribute to the development of Alzheimer's Disease. The study will be conducted over a period of 18 months involving 500 people.

Because NILVADIPINE is already available and licensed, this type of study can be carried out more quickly, to the potential benefit of future generations of people with Alzheimer's disease, their caregivers and society.


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Contact: Caoimhe Ni Lochlainn
communications@tcd.ie
353-189-62310
Trinity College Dublin
Source:Eurekalert

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