Navigation Links
Clinical trial to test whether vaccine can effectively treat melanoma
Date:4/6/2010

f the vaccine's efficacy, included 50 patients with metastatic melanoma, or melanoma that had spread to other parts of the body, who had failed to respond to conventional treatment, including chemotherapy and immunological drugs such as interleukin-2. Response rates for those therapies are at best about 15 percent, according to Kaufman.

By comparison, the overall response rate in the OncoVEX trial was 26 percent. Eight of the 50 patients were free of disease by the end of the trial period, which consisted of vaccination every two weeks, for a total of up to 24 injections or until disease disappeared. Four more patients were rendered disease-free after surgery or further vaccination of new lesions. Overall survival was 58 percent at one year, and 52 percent at two years. The results were reported last December in the Journal of Clinical Oncology.

"What really surprised, and encouraged, us was that the vaccine worked not just on the cells we injected, but on lesions in other parts of the body that we couldn't reach," Kaufman said. "In other words, the vaccine prompted an immune response that was circulated through the bloodstream to distant sites.

"These are the best results to date for any vaccine developed for melanoma, but they need to be confirmed in a larger population."

The Phase III trial will enroll a total of 430 patients at centers across the U.S. As with the earlier trial, the vaccine will be injected directly into tumor nodules every two weeks for up to 24 treatments. Patients will be tracked for two years after the first dose is received.

BioVex, in Woburn, Massachusetts, which makes OncoVEX, is funding the study.


'/>"/>

Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The CPM Resource Center launches Web-based clinical practice guidelines
2. Clinical benefit of multiple sclerosis drug discovered at Rush University Medical Center
3. Childrens Hospital Bostons Pain Treatment Service is named Clinical Center of Excellence
4. Almac to Improve Label Approval Process in Clinical Trials
5. Targeted agent blocked growth of deadly brain cancer in preclinical studies
6. New clinical prediction index to help patients considering kidney transplant
7. Kineta Awarded NIH Grant to Complete Preclinical Studies on Type 1 Diabetes / Multiple Sclerosis Drug Candidate
8. Childhood cancer patients enrolled in clinical trials need clearer communication about their role
9. Medical schools partner to tackle barriers to minority participation in cancer clinical trials
10. Carefx to Provide Clinical Workflow Solutions for Military Health System
11. The Indiana Clinical and Translational Science Institute (CTSI) Licenses GeneGos Eureka and MetaCore Platforms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 2014 Sean Francis, owner of the Kawartha Lakes ... to his clients. He’s also known for his support of local ... way to combine the two and is excited to announce that ... Boys and Girls Club. , The funds are the result of ... 23rd. Francis sent out emails and asked his clients to put ...
(Date:7/12/2014)... prom shopping reaching its final days, VogueQueen.com, a renowned ... its new and trendy apparels. Recently, the company has ... online shop. Additionally, it is now providing huge discounts ... to the company’s sales manager, the promotion will come ... He says, “Now, worldwide clients can order cheap ...
(Date:7/12/2014)... 12, 2014 Doylestown Hospital recently conducted ... of men’s health questions. Paddock tackles topics including ... why women live longer than men, and testosterone replacement ... Made Simple featured on Doylestown Hospital’s website, Dr. ... at any age. If you notice pain, bulging, or ...
(Date:7/12/2014)... July 12, 2014 A recent article released ... a trio of suggestions for those seeking cosmetic surgical ... are rapidly approaching and the heat begins to enliven the ... their summer clothing, realizing that they didn’t work out as ... This can cause a sudden surge of people eager to ...
(Date:7/12/2014)... CA (PRWEB) July 12, 2014 ... power score of 4.1 out of 5. This ... that have been underpinning buyer negotiation power over ... procurement analyst Anna Son, “during the period, surging ... rising costs associated with new product development, have ...
Breaking Medicine News(10 mins):Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4
... designed program, study finds , MONDAY, Nov. 30 (HealthDay ... toddlers with autism succeeded in boosting IQ along with ... , "When done in this fashion, many children are ... Dawson, lead author of the study, published online Nov. ...
... , NEW ... new market research report is available in its ... Key ingredients, strategic issues and targeted opportunities for ... Seniors, have emerged as a powerful consumer audience ...
... Salon Leau announced today they are hosting "Cuts For A Cause" ... in the fight against childhood terminal diseases. All proceeds from each ... Research Hospital. , Salon Leau has been serving the posh ... LoAnn Lai, widely recognized for her innovation in color, cuts and ...
... , DEL MAR, Calif., Nov. 30 ... to announce the appointment of Howard M. McEldowney ... Mr. McEldowney, whose investment career spans over a 40 year ... and subsequently a founding partner of Harris, Bretall & McEldowney, ...
... N.J., Nov. 30 Advanced Health Media, LLC (AHM), the ... compliance management software for the life sciences industry, announced it ... state by NJBIZ, New Jersey,s leading statewide business newspaper. ... that have made significant contributions to the state,s growth, strength ...
... , CHICAGO, Nov. 30 Physicians at Beth Israel ... a study demonstrating the potential for automated analysis of ... to assist in rapidly ruling out coronary artery stenosis ... pain. The ability of the automated system to enhance ...
Cached Medicine News:Health News:Working Intensely Early on May Help Autistic Kids 2Health News:Working Intensely Early on May Help Autistic Kids 3Health News:Working Intensely Early on May Help Autistic Kids 4Health News:Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers 2Health News:Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers 3Health News:Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers 4Health News:Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers 5Health News:Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers 6Health News:Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers 7Health News:Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers 8Health News:Georgetown Hair Salon Helps St. Jude Find A Cure 2Health News:American Diversified Holdings Corporation Announces Appointment of Independent Director to the Board of the Company 2Health News:Advanced Health Media Honored at NJ Finest Award Ceremony 2Health News:Rcadia COR Analyzer(R) System Demonstrates Potential in Emergency Department Triage of Chest Pain Patients at Low to Moderate Risk of Coronary Artery Disease 2Health News:Rcadia COR Analyzer(R) System Demonstrates Potential in Emergency Department Triage of Chest Pain Patients at Low to Moderate Risk of Coronary Artery Disease 3
(Date:7/11/2014)... -- Rock Creek Pharmaceuticals, Inc. (NASDAQ: RCPI ), ... and Drug Administration ("FDA"), has notified the Company that ... Drug ("IND") application before granting the Company permission to ... Dr. Chris Chapman , RCP,s President, commented, "We ... When we receive the agency,s official comments and/or recommendations, ...
(Date:7/11/2014)... , July 11, 2014 ... Market by Composition of Material, Application (Healthcare, Homeland ... End Product (Personal Instrument, Hand-Held Instruments, Fixed, and ... Analysis to 2013 - 2020", published by MarketsandMarkets, the Scintillator ... of 5.62% from 2014 to 2020, and reach ...
(Date:7/11/2014)...  Kindred Hospital Houston Northwest, with Wound Care ... its new outpatient wound healing center.  The wound ... chronic, hard to heal wounds. Chronic wounds include ... lower leg wounds related to blood flow issues, ... injury wounds which are complex and demonstrate delayed ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Issues Update On US Investigational New Drug Application 2Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2
... , MAPLE GROVE, Minn., Dec. 3 Upsher-Smith ... plan for central nervous system (CNS) diseases with USL255 (extended ... epilepsy. USL255 is being developed with Upsher-Smith,s proprietary formulation technology ... 2010 for the adjunctive treatment of epilepsy patients with partial ...
... , HARRISBURG, Pa., Dec. 3 ... processing company build a new cold storage facility and ... at least 20 jobs, Governor Edward G. Rendell announced ... more than $2.9 million for three projects. The investments, ...
Cached Medicine Technology:Upsher-Smith Announces Milestone in Development of CNS Strategy 2Governor Rendell: New State Investments Bear Fruit in Adams County; Help Pharmaceutical Company Expand in Philadelphia 2
Inquire...
Inquire...
The Optima III 45 cm line of laparoscopic hand instruments is ideal for operative laparoscopic/endoscopic procedures or when a longer instrument is needed....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Medicine Products: