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Clinical trial success influenced by biomarker- and receptor-targeted therapies in NSCLC
Date:2/14/2014

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The cumulative success rates for small-molecule and biologic drugs for advanced NSCLC were lower than industry aggregate rates; the rate for small-molecule drugs was 17% (compared with the industry aggregate of 32%) and the rate for biologic drugs was 10% (compared with 13%). When the impact of the mechanism of action was analyzed, the cumulative success rate was 31% for receptor targeted therapies, such as bevacizumab, crizotinib, erlotinib, and gefitinib, which was nearly threefold better than nontargeted therapies (11%). The rate was lowest (6%) for immunotherapy.

"Our analysis suggests that biomarker targeted treatment indications and compounds that have a receptor targeted mechanism of action offer the best chance of clinical success in this indication and should be the focus of future clinical trial development," says first author Adam Falconi, BSc, Pharm, of the Department of Pharmacy, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada. Clinical trials involving the use of biomarkers and receptor targeted therapies should be a priority for patients with advanced NSCLC who wish to enroll in a clinical trial.

The third coauthor of the study, Gilberto Lopes, MD, of Johns Hopkins University School of Medicine, Baltimore, Maryland, and HCor Onco Cancer Center for Hospital do Corao, Brazil, is an IASLC member on the Career Development Committee.


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Contact: Kristin Richeimer
kristin.richeimer@iaslc.org
720-325-2953
International Association for the Study of Lung Cancer
Source:Eurekalert

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