Navigation Links
Clinical trial success influenced by biomarker- and receptor-targeted therapies in NSCLC
Date:2/14/2014

DENVER Over the past decade, a great clinical focus has been directed at developing new and innovative therapies for advanced non-small cell lung cancer (NSCLC). An analysis of clinical trials evaluating these therapies demonstrates that the cumulative success rate for new agents for advanced NSCLC is lower than the industry-estimated rate. However, biomarker- and receptor-targeted therapies were found to substantially increase clinical trial success.

The analysis was designed to evaluate the risk of clinical trial failure in advanced (stage IIIb-IV) NSCLC drug development over the past 14 years. The success rate was defined as the likelihood that a new drug would pass all phases of clinical trial testing and be approved. Success rates were compared with rates estimated by the biopharmaceutical industry as well as rates determined by risk analysis research in other disease indications.

The success rate for NSCLC drug development was 11%, which is lower than the industry estimate of 16.5%. However, success rates were higher for certain drug indications; the cumulative success rate was 62% for biomarker targeted therapy, which was nearly six times higher than the rate for trials without a biomarker targeted indication (11%). The analysis also showed that success rates became worse with each new phase of testing, which indicates that earlier phase trials may provide little help in ensuring the success of later phase trials.

"The findings suggest that some treatment modalities and drug design strategies may help to decrease drug-development risk and promote the development of innovative drugs to treat advanced NSCLC," says lead author Jayson Parker, PhD, MBA, of the Department of Biology, University of Toronto at Mississauga, Toronto, Ontario, Canada. A report on the findings of the analysis is published in the February issue of the International Association for the Study of Lung Cancer's journal, the Journal of Thoracic Oncology'/>"/>

Contact: Kristin Richeimer
kristin.richeimer@iaslc.org
720-325-2953
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. Clinical insight improves treatment with new lung cancer drug
3. Clinical news alert from the American Academy of Orthopaedic Surgeons
4. NYU Langone experts present research, clinical advances at neurosurgeons meeting
5. Kroenke honored for outstanding contributions in clinical research training
6. Awards celebrate clinical research that can improve health and alleviate suffering
7. Association for Psychological Science, SAGE launch Clinical Psychological Science
8. URMC clinical trial tests new regimen for hypertension
9. Analysis Finds Clinical Trials Often Small, of Poor Quality
10. Automated insulin dosage titration system demonstrates positive clinical study results
11. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... ... Florida Hospital North Pinellas, located at 1395 South Pinellas Avenue in Tarpon Springs, will open ... will be located at US Highway 19 North and Highlands Boulevard, less than eight miles ... on the project is slated to begin in September 2015. , The new ...
(Date:8/27/2015)... ... August 27, 2015 , ... King Kullen, America’s First Supermarket, is celebrating 85 ... Cullen in 1930 and recognized by the Smithsonian Institute as America’s First Supermarket, King ... operated, the Cullen & Kennedy families have created a culture of caring while building ...
(Date:8/27/2015)... ... 2015 , ... Since its launch on August 16, 2007, ... in three counties, LA, Orange and San Bernardino. Their twenty physicians have ... Dr. Richy Agajanian, the Oncology Institute of Hope and Innovation is dedicated to ...
(Date:8/27/2015)... ... August 27, 2015 , ... ... solutions for drugs, biologics and consumer health products, today announced that Ms. Esther ... Conference, to be held at the Radisson Blu Edwardian Hotel, London Heathrow, on ...
(Date:8/27/2015)... ... 27, 2015 , ... "I need a little help supporting and stabilizing myself ... Camp Hill, Pa. "I developed this support handle to give me the extra little ... GRIP to provide a helping hand when stepping into or out of the tub ...
Breaking Medicine News(10 mins):Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 2Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 3Health News:King Kullen Honors Their 85 Years of Success this August 2Health News:California’s Largest Private Oncology Practice Serves 50,000 Patients in 8 years 2Health News:Clinical Trial Supply Chain Logistics to be Discussed By Catalent Expert at Upcoming Flypharma Conference 2Health News:Inventor and InventHelp Client Develops Bathroom Stabilization Aid (LCC-432) 2
... infections (UTI) are often caused by bacteria and ... Fluoroquinolones have been recommended empirical therapy for treatment ... high activity against E. coli that causes the ... formulation of ciprofloxacin may provide a convenient// once-daily ...
... helps in natural tumor control process. They said radiotherapy ... conducted on mice researchers identified an cell suicide enzyme, ... tumor nourishing blood vessels to die. Tumors cannot survive ... that damage to the DNA in the nuclei of ...
... from Australia says that older people taking anti-depressants are ... its not so much that anti-depressants do, but its ... peoples psychological stress, help treat them. There has been ... of depression and responding to them. With data collected ...
... cancer could save thousands of lives. Doctors found that nodular ... cancers but caused up to 70 per cent of the ... melanoma is the most dangerous. However these are often missed ... melanoma. It appears anywhere on the body, often the head ...
... an electronic nose which is capable of sniffing out distinctive ... 60 patients and proved to be accurate. The electronic nose ... olfactory system. The patient is asked to exhale into a ... is then pumped inside the cube and hence into the ...
... In a recent study Scientists have discovered that the substance ... natural moisturizer, wound-healer and antiseptic. The greasy, white secretion, called ... early at 32 to 33 weeks are covered with vernix. ... at the Cincinnati Children's Hospital Medical Center says that vernix ...
Cached Medicine News:
(Date:8/27/2015)... PUNE, India , August 27, 2015 ... "Radiology Information Systems Market by Type (Integrated, Standalone), by ... (Hospitals, Office based Physicians, Emergency Healthcare Service Providers), by ... global Radiology Information Systems Market is estimated at $501.1 ... by 2019, at a CAGR of 7.6% from 2014 ...
(Date:8/27/2015)... , Aug. 27, 2015  BioElectronics Corporation (OTC Pink: ... today that three abstracts featuring the use of ActiPatch®, ... the 9 th Congress of the European Pain ... th September 2015. The Company will also be ... Dr Gianluca Bagnato , department clinical and experimental ...
(Date:8/27/2015)...   Americord Registry , a private cord ... tissue banking company, announced today the launch of ... new website makes the expecting parent,s cord blood banking ... and checkout process. Logo - http://photos.prnewswire.com/prnh/20150827/261520LOGO ... make this service difficult to purchase online. We want ...
Breaking Medicine Technology:Radiology Information Systems Market Worth $722.7 Million by 2019 2Radiology Information Systems Market Worth $722.7 Million by 2019 3Radiology Information Systems Market Worth $722.7 Million by 2019 4BioElectronics Selected to Present its Pain Research and Devices at the European Pain Federation Conference 2Cord Blood Bank Revolutionizes Process of Online Cord Blood Banking 2
The Aortic Root Cannulae With Vent Line are flanged, with radiopaque tips; two side holes in tip....
The KAVD Venous Cannula is the first of its kind. It is a combination of cannulae/venous line designed to "bridge the gap between the patient and the Medtronic Resting Heart System circuit....
... Medtronic Select CAP® cannulae provides a ... pressure readings. An innovative combination of ... monitoring line, the Select CAP® can ... central arterial pressure readings on which ...
Intermittent catheter...
Medicine Products: