Navigation Links
Clinical trial looks to improve pancreatic cancer survival rates

AUGUSTA, Ga.Researchers at Georgia Regents University Cancer Center are investigating a new avenue of treatment to help boost poor pancreatic cancer survival rates.

The treatment combines a standard chemotherapy drug with a monoclonal antibody that may help the immune system fight pancreatic cancer.

Every year, nearly 44,000 patients are diagnosed with pancreatic cancer and more than 37,000 die from the diseaseincluding well-known figures such as Patrick Swayze, Margaret Mead and Luciano Pavarotti.

Despite increased public attention, the disease remains one of the deadliest forms of cancer because it tends to be symptom-free at its earliestand most treatablestages. Overall five-year survival rates are a dismal 5.6 percent.

Patients treated with surgery typically see their cancers recur within about seven months. Coupling surgery with the chemotherapy drug Gemcitabine in eligible patients extends disease-free survival to a little over 13 months. Now, researchers are turning to combination therapies to improve these rates, coupling chemotherapy with drugs that enhance the immune system's ability to fight cancer.

"One of the reasons cancer can be so difficult to treat is the fact that the immune system often doesn't recognize tumor cells as cancer, or the tumors themselves express substances to suppress the immune system," said GRU Cancer Center Director Samir N. Khleif. "Immunotherapy is considered to be an important approach since it targets those specific substances in order to establish a more effective response against cancer."

Promise has already been shown in monoclonal antibodies that fight cancer's ability to evade the immune system, said Khleif, who is the principal investigator on a pilot study combining Gemcitabine with a monoclonal antibody called CT-011 in certain pancreatic cancer patients who have been treated with surgery.

In animal models, CT-011 has been shown to inhibit tumor growth and extend survival in melanoma, lung cancer, fibrosarcoma, leukemia/lymphoma and colorectal cancer. It works by shutting down cell production of a protein called PD1 and its related proteins. PD1, also known as programmed death 1, triggers immune suppression in cancer.

"One of the main causes for immune suppression in pancreatic cancer and other cancers is the elevated expression of these proteins in tumors and surrounding cells," said Khleif. "This is why our cancer center is taking a leading role in advancing clinical trials examining the effectiveness of combination therapieswhich are increasingly being recognized as a promising new avenue of treatment for cancer."


Contact: Danielle Moores
Georgia Health Sciences University

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. Clinical insight improves treatment with new lung cancer drug
3. Clinical news alert from the American Academy of Orthopaedic Surgeons
4. NYU Langone experts present research, clinical advances at neurosurgeons meeting
5. Kroenke honored for outstanding contributions in clinical research training
6. Awards celebrate clinical research that can improve health and alleviate suffering
7. Association for Psychological Science, SAGE launch Clinical Psychological Science
8. URMC clinical trial tests new regimen for hypertension
9. Analysis Finds Clinical Trials Often Small, of Poor Quality
10. Automated insulin dosage titration system demonstrates positive clinical study results
11. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
Post Your Comments:
Related Image:
Clinical trial looks to improve pancreatic cancer survival rates
(Date:10/13/2015)... ... October 13, 2015 , ... Altec ... their Title Sponsorship of Synergy 2015. The annual WennSoft KEY2ACT user conference will ... Ranch and will unite customers, partners, WennSoft team members and sponsors to facilitate ...
(Date:10/13/2015)... ... 13, 2015 , ... Georgia Partnership for TeleHealth ... Georgia, along with affiliate organizations, Alabama Partnership for Telehalth (ATP) and Florida Partnership ... Fall 2015. , Each of the three conferences share this year’s conference ...
(Date:10/13/2015)... ... October 13, 2015 , ... Local Gold’s Gym franchise owner, Bryce Berry, received ... 26. Berry, who owns and operates Gold's Gym Cheyenne in Cheyenne, Wyoming, ... in the United States. A brand leader in global fitness, Gold’s Gyms are located ...
(Date:10/13/2015)... ... October 13, 2015 , ... With Fall weather approaching ... tool for this month’s Facebook Hair Styler Contest. , Enter to win! , How ... Answering: What Is Your Favorite Hair Style? , 3. Follow us on Instagram ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... home furnishings and décor, today announced it closed on a $20.5 million funding ... will be used to support the Company’s continued rapid growth and expansion, broaden ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015   Rosa & Co. ... in Quantitative Systems Pharmacology (QSP)/ PhysioPD™ , today announced ... lead a workshop at the QSP Congress Meeting ... Boston, MA.  The conference focuses on ... development.  Dr. Friedrich,s workshop is entitled "Using Mechanistic Physiological ...
(Date:10/13/2015)... World Thrombosis Day Interactive Infographic ...   --> World Thrombosis Day Interactive ... promote vital global awareness of thrombosis, its causes, ... the formation of potentially deadly blood clots in ... thromboembolism (VTE) - or the artery (arterial thrombosis) [1] ...
(Date:10/12/2015)... Apheresis is an invasive process that involves ... other components from whole blood. In this procedure, the blood ... apheresis machine or a blood cell separator. The apheresis equipment ... blood components. A selected part of the blood is removed, ... the patient. It involves the use of devices and disposables ...
Breaking Medicine Technology: