Navigation Links
Clinical trial looks to improve pancreatic cancer survival rates
Date:2/12/2013

AUGUSTA, Ga.Researchers at Georgia Regents University Cancer Center are investigating a new avenue of treatment to help boost poor pancreatic cancer survival rates.

The treatment combines a standard chemotherapy drug with a monoclonal antibody that may help the immune system fight pancreatic cancer.

Every year, nearly 44,000 patients are diagnosed with pancreatic cancer and more than 37,000 die from the diseaseincluding well-known figures such as Patrick Swayze, Margaret Mead and Luciano Pavarotti.

Despite increased public attention, the disease remains one of the deadliest forms of cancer because it tends to be symptom-free at its earliestand most treatablestages. Overall five-year survival rates are a dismal 5.6 percent.

Patients treated with surgery typically see their cancers recur within about seven months. Coupling surgery with the chemotherapy drug Gemcitabine in eligible patients extends disease-free survival to a little over 13 months. Now, researchers are turning to combination therapies to improve these rates, coupling chemotherapy with drugs that enhance the immune system's ability to fight cancer.

"One of the reasons cancer can be so difficult to treat is the fact that the immune system often doesn't recognize tumor cells as cancer, or the tumors themselves express substances to suppress the immune system," said GRU Cancer Center Director Samir N. Khleif. "Immunotherapy is considered to be an important approach since it targets those specific substances in order to establish a more effective response against cancer."

Promise has already been shown in monoclonal antibodies that fight cancer's ability to evade the immune system, said Khleif, who is the principal investigator on a pilot study combining Gemcitabine with a monoclonal antibody called CT-011 in certain pancreatic cancer patients who have been treated with surgery.

In animal models, CT-011 has been shown to inhibit tumor growth and extend survival in melanoma, lung cancer, fibrosarcoma, leukemia/lymphoma and colorectal cancer. It works by shutting down cell production of a protein called PD1 and its related proteins. PD1, also known as programmed death 1, triggers immune suppression in cancer.

"One of the main causes for immune suppression in pancreatic cancer and other cancers is the elevated expression of these proteins in tumors and surrounding cells," said Khleif. "This is why our cancer center is taking a leading role in advancing clinical trials examining the effectiveness of combination therapieswhich are increasingly being recognized as a promising new avenue of treatment for cancer."


'/>"/>

Contact: Danielle Moores
dwongmoores@yahoo.com
706-496-5956
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. Clinical insight improves treatment with new lung cancer drug
3. Clinical news alert from the American Academy of Orthopaedic Surgeons
4. NYU Langone experts present research, clinical advances at neurosurgeons meeting
5. Kroenke honored for outstanding contributions in clinical research training
6. Awards celebrate clinical research that can improve health and alleviate suffering
7. Association for Psychological Science, SAGE launch Clinical Psychological Science
8. URMC clinical trial tests new regimen for hypertension
9. Analysis Finds Clinical Trials Often Small, of Poor Quality
10. Automated insulin dosage titration system demonstrates positive clinical study results
11. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clinical trial looks to improve pancreatic cancer survival rates
(Date:3/24/2017)... ... March 24, 2017 , ... The law firm of Enea, Scanlan ... to announce Westchester resident Lauren C. Enea has joined the firm as an associate ... concentrate her practice in elder law, Medicaid planning and applications, and Wills, Trusts and ...
(Date:3/24/2017)... ... , ... “Finding Christ Through Social Media: Year One #A365DayJourney ... writer’s path toward true communion with God. “Finding Christ Through Social Media: Year ... of published author Lea Michelle Johnson, a follower of Christ, wife and mother ...
(Date:3/23/2017)... ... March 23, 2017 , ... In 2016 the World Health Organization declared ... be four million Zika-related cases in the Americas within the next year. Lyme disease ... reported per year skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other insect ...
(Date:3/23/2017)... ... 23, 2017 , ... PAINWeekEnd (PWE) Oklahoma City, on April ... will be an educational and exciting program providing busy clinicians and allied healthcare ... pain. , Oklahoma is in a healthcare crisis. The state ranks 46th in ...
(Date:3/23/2017)... ... 23, 2017 , ... March is National Kidney Month – the perfect time ... to maintaining good health. Every day, two kidneys filter about 120 to 150 quarts ... your blood, eliminating waste, regulating fluid levels and blood pressure, supporting bone health and ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Mar. 24, 2017 Research and Markets has announced ... Growth and Demand Forecast to 2022" report to their offering. ... The global wound care market ... at a CAGR of 6.7% during 2016-2022 Among the various ... largest share in the global market in 2015. Among the various applications, ...
(Date:3/24/2017)... NEW YORK , March 24, 2017 ... ... Research, a leading publisher of cannabis market research, the legal ... 27 percent CAGR through 2021, despite conflicting signals from the ... Analytics, points out that the two biggest drivers of growth ...
(Date:3/24/2017)... Global Ampoules Market report provides ... applications and industry chain structure. The Ampoules market analysis ... competitive landscape analysis, and major regions, development status. ... ... providing 10 company profiles and 183 tables and figures ...
Breaking Medicine Technology: