Navigation Links
Clinical trial for dry mouth funded by international oral care award
Date:3/16/2011

AUGUSTA, Ga. A clinical trial using an all-natural lozenge to treat dry mouth, a condition that impacts 40 percent of American adults, is under way at Georgia Health Sciences University College of Dental Medicine.

"These patients' mouths are as dry as if you've closed the faucet, and we want to turn that faucet back on," said Dr. Stephen Hsu, Molecular and Cell Biologist and co-investigator of the study. "The cells and glands that produce saliva are still there, they're just not working."

Through previous animal studies and human sample testing, GHSU researchers found that dry mouth involves salivary gland inflammation, fewer antioxidants and elevated markers for abnormal growth and DNA damage caused by free radicals. Powerful antioxidants in green tea, called polyphenols, reduce that damage to the salivary gland.

"With green tea polyphenols, we have an agent that's helping to correct the salivary gland's abnormal behavior," said Dr. Douglas Dickinson, Associate Professor in the Department of Oral Biology and co-investigator.

The team formulated an all-natural lozenge containing green tea polyphenols, xylitol and jaborandi leaf extract, a plant used in South and Central America to promote saliva production. The lozenge offers a slow, extended release only in the mouth, not the systemic effect caused by prescription dry-mouth medication, which can prompt side effects such as diarrhea and excessive sweating, said Dr. Scott De Rossi, Chairman of the Department of Oral Health and Diagnostic Sciences and principal investigator.

Sixty patients will be followed during the eight week trial, with half taking the lozenge and half taking a placebo. The four daily doses of the lozenge taken during the trial are equivalent to drinking four or five cups of green tea, which benefits overall health, the researchers added.

"I think the promise here is that patients are going to feel better and we're going to see some improv
'/>"/>

Contact: Paula Hinely
phinely@georgiahealth.edu
706-721-3646
Georgia Health Sciences University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Revitalizing Cancer Clinical Trials -- March 21 symposium
2. Novel clinical trial aims to reduce recurrence of aggressive breast cancer
3. Clinical observation leads to lung cancer discovery
4. Study reveals security weaknesses in file-sharing methods used in clinical trials
5. UT Southwestern launches clinical trial for treatment of breast cancer using CyberKnife
6. Elsevier/MEDai enhances real-time clinical surveillance system for hospitals
7. Few physicians refer patients to cancer clinical trials
8. Older adults often excluded from clinical trials
9. New clinical trial to determine ovarian cancer risks in African-American women
10. Case Western Reserve/University Hospitals join nationwide HIV vaccine clinical trial
11. Most Guidelines for Infectious Diseases Dont Come From Clinical Trial Findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... July 03, 2015 , ... Brendon Burchard's new High ... of media attention. In an effort to spread the news, a comprehensive review ... days many people are feeling overwhelmed by stress and fatigue," reports Hendricks. "Many ...
(Date:7/3/2015)... ... July 03, 2015 , ... B. E. ... been retained to lead a national president recruitment for Regional Care, ... healthcare industry, B. E. Smith has recently placed more than 1,000 healthcare executives ...
(Date:7/3/2015)... ... July 03, 2015 , ... Jennifer Renee Hanes, DO is the new ... the largest network of independent freestanding emergency rooms in the United States. , “We ... Sienna Plantation facility,” said Executive Medical Director of First Choice Emergency Room, Dr. James ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Celebrity Dresses is ... dresses similar to those of celebrities will have the opportunity to get 10% discount ... This ensures that people do not have to use coupon codes or remember redemption ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... Donna Edwards (D-Md.) for her introduction of the Stop Overdose Stat (S.O.S.) Act ... by Senator Jack Reed (D-R.I.), this Act seeks to decrease drug overdose – ...
Breaking Medicine News(10 mins):Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 2Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 3Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3
... 15 years ago scientists discovered a way to stop ... finding holds tantalizing promise for medical science, but so ... known as RNA interference, in living cells., Now scientists ... University in Atlanta have succeeded in using nanotechnology known ...
... for cancer research is complete. There are more unclimbed ... mountains to challenge., ... the Big Expedition for Cancer Research determined that they,had reached the safe ... hours, they battled unstable snow, ice and rock to,move within 500 vertical ...
... Health Ministers Meet to Focus on Link Between Health and,Economic ... It has long been accepted that greater wealth allows ... Does greater health lead,to greater wealth, both on a personal ... of health, international experts, and,over 500 delegates from the 53 ...
... by last year,s "Live,Your Best Life Spa Week" held at ... legacy of giving back by once again hosting the,most deserving ... contest,people all across the country can nominate contestants who are ... will enjoy a four-day,three-night retreat at the country,s top rated ...
... the hope in transplantation and raise awareness of the ... need for organ and tissue donations, ... (JRI) and world-renowned mountain,climber and heart transplant recipient, Kelly Perkins, are ... Heart. Share the,Beat" where Perkins and her husband Craig will scale ...
... urge athletes, coaches and trainers to follow simple steps ... to ... 23 Methicillin-resistant,Staphylococcus aureus, commonly referred to as MRSA, ... a class of common antibiotics that,includes methicillin, penicillin, amoxicillin ...
Cached Medicine News:Health News:Gene silencer and quantum dots reduce protein production to a whisper 2Health News:Gene silencer and quantum dots reduce protein production to a whisper 3Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 2Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 3Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 4Health News:Big Expedition Ends Peak 8290 Attempt 500 Feet From the Summit 5Health News:Does Better Health Lead to Better Wealth? 2Health News:Does Better Health Lead to Better Wealth? 3Health News:Miraval Tucson to Continue Legacy of Awarding Spa Vacation 2Health News:Heart Recipient Kelly Perkins Scales Half Dome to Support 'Exercise Your Heart. Share The Beat' 2Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 2Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 3Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 4Health News:American Academy of Dermatology Research Shows Athletes Susceptible to Antibiotic-Resistant Staph Infections 5
(Date:7/4/2015)... , July 4, 2015 ... for patients with unresectable metastatic colorectal cancer in ... that organ Patients with unresectable metastatic ... the liver experienced the greatest improvement in Progression-Free ... of SIR-Spheres Y-90 resin microspheres to a current ...
(Date:7/3/2015)... July 4, 2015 A global ... hypertension, diabetes and thyroid disorders in Central and ... platforms and a major conference dedicated to these diseases. ... Manage Diabetes Online , Manage Hypertension Online ... and operated by EXCEMED - combine the ...
(Date:7/3/2015)... July 3, 2015 Un ... épidémies que sont l,hypertension, le diabète et les ... plateformes éducatives gratuites et d,une conférence majeure dédiée ... http://photos.prnewswire.com/prnh/20150630/227033 ) , Les formations ... , Prendre en charge l,hypertension en ligne ...
Breaking Medicine Technology:New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 2New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 4Combating Three Major Chronic Diseases in Central and South-East Asia With Medical Education 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 3
... , WILMINGTON, Del. , Jan. ... plans have been approved by the Food & Drug Administration since their ... and report on how well these plans have actually been working in ... will be the topic of an open industry webinar at 12 ...
... , ST. LOUIS , Jan. 12 ... entered a distribution agreement with Eka Chemicals to offer Eka,s ... small molecules, peptides and proteins in the pharmaceutical and biotechnology ... and Puerto Rico , and expands Sigma-Aldrich,s portfolio ...
Cached Medicine Technology:REMS Assessment Webinar to Examine How to Measure Effectiveness of Drug Safety Plans 2Sigma-Aldrich Becomes the Sole U.S. and Canada Distributor of Kromasil(R) HPLC Columns Through Agreement With Eka Chemicals 2Sigma-Aldrich Becomes the Sole U.S. and Canada Distributor of Kromasil(R) HPLC Columns Through Agreement With Eka Chemicals 3Sigma-Aldrich Becomes the Sole U.S. and Canada Distributor of Kromasil(R) HPLC Columns Through Agreement With Eka Chemicals 4
... Designed for Western, Northern, or Southern ... gels with dimensions as large as ... internal cooling base for temperature controlled ... power leads. Additional blotting ...
... electrophoretic transfer apparatus incorporating state-of-the-art plate electrodes for ... for a very close positioning of the electrodes ... source such as a battery charger, creates a ... rapid and exact electrophoretic transfer. ...
... power supply. Flexibility for ... Transfers. Native Enzyme, High ... Faster, Higher-Efficiency Transfers via Plate ... with Movable Electrodes. Simple ...
... 2 gel holder cassettes, cell ... fiber pads, blot absorbent paper ... Trans-Blot transfer cell, used with ... performs efficient, high-intensity electrophoretic transfers. ...
Medicine Products: