Navigation Links
Clinical trial demonstrates that rilonacept significantly reduces gout flares
Date:1/4/2012

A phase II clinical trial found that rilonacept, an inhibitor of the protein interleukin-1 (IL-1), significantly reduced acute gout flares that occur when initiating uric acid-lowering therapy. Results of the trialthe first placebo-controlled study investigating IL-1 targeted therapy in prevention of gout flaresshow rilonacept to be generally well tolerated with no serious infections or treatment-related serious adverse events reported. Full findings are published in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR).

Patients with gouta type of inflammatory arthritis caused by the crystallization of urates in soft tissuesexperience severe pain and swelling, often affecting the feet. A recent study also published in Arthritis & Rheumatism reported that doctor-diagnosed gout has risen over the past twenty years and now affects 8.3 million individuals in the U.S. Previous research shows that while gout attacks typically resolve spontaneously over several days, urate crystals remain in the joint, which can lead to recurrent attacks and if left untreated may permanently damage joints.

"To reduce deposits of crystals in the joints, we advise patients to initiate treatment with medications that lower levels of uric acid in the blood," said lead investigator Dr. H. Ralph Schumacher, Jr., Professor of Medicine at the University of Pennsylvania School of Medicine. The authors explain that in the early months of urate-lowering therapy, as crystal deposits are broken up, patients may experience gout attacks that are proposed to be due to the release of crystals from softened deposits. These urate crystals interact with cells that release interleukin-1 (IL-1) which can lead to a cascade of inflammation and acute joint pain flares.

Previous research has found that acute gout attacks brought on by uric acid-lowering therapy may make patients less likely to continue treatment. "Well tolerated drugs that reduce
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stethoscope App gives iPhone New Clinical Skills
2. Sunquest Introduces Integrated Clinical Environment Physician Portal Solution in US
3. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
4. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
5. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
6. NOVAVAX Presents Positive Clinical Results at The World Health Organization Conference, Geneva, Switzerland
7. UCLA Health System Presents: How to Successfully Implement a Clinical Portal
8. TeraMedica Launches Evercore – Clinical Enterprise Suite 5.0 Now on Linux
9. Mesothelioma Clinical Trials List Offered by IQ Mesothelioma: Search Current Mesothelioma Treatment Options
10. MedQuist Launches EHR Integration for Dictations Associated with Template-based Clinical Documentation
11. Greenway Medical Technologies Donates Electronic Health Record, Clinical Research and Revenue Cycle Solutions to Northern Kentucky University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 The Technology Association ... Alliance of TAG (B&TA), today issued its final call ... Awards. , Interested companies have until August 29th 2014 ... Semi-Finalists will be selected by the Excalibur Judging Committee. ... meet with the judges for interviewing process. , ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 As the ... ) in gynecological surgeries continues to grow, Bernstein Liebhard ... to those calling for a ban on uterine morcellation. ... Valverde was diagnosed with leiomyosarcoma following a hysterectomy that ... year of her diagnosis, the aggressive cancer had progressed ...
(Date:7/30/2014)... New York, NY (PRWEB) July 30, 2014 ... largest nutrition school, is pleased to announce that Arianna Huffington ... in the curriculum of the Health Coach Training Program ... of The Huffington Post, a world-renowned news and blogging site ... Huffington is the author of fourteen books and was included ...
(Date:7/30/2014)... The report "Peracetic Acid Market by Type (Disinfectant, Sanitizer, ... Pulp & Paper, & Others), by Geography (North America, ... to 2018". Peracetic Acid Market is projected to reach ... a robust growth rate of over 6.2% during the ... and 33 figures spread through 221 Slides and in-depth ...
(Date:7/30/2014)... sub-groups of cells jockeying for supremacy within a cancerous ... can proliferate the fastest, researchers at Dana-Farber Cancer Institute ... publication of the journal Nature . The ... with precision medicines, the study authors explained: Doctors need ... tumor,s growth and metastasis and select drugs that target ...
Breaking Medicine News(10 mins):Health News:Last Call for TAG 2014 Excalibur Awards Nominations and Applications 2Health News:Last Call for TAG 2014 Excalibur Awards Nominations and Applications 3Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 2Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 3Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 4Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 3Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 2Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 3Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 4Health News:Target growth-driving cells within tumors, not fastest-proliferating cells 2Health News:Target growth-driving cells within tumors, not fastest-proliferating cells 3
... , ... VP for Healthcare Industry , ... Dayton, OH (Vocus) September 28, 2009 -- Sogeti, a leading international provider of professional IT ... Healthcare to further the industry expertise that it provides to clients., , ,With ...
... them, survey shows , MONDAY, Sept. 28 (HealthDay News) -- ... the growth charts widely used in pediatrician,s offices, but many ... a new survey shows. , About 85 percent of parents ... and correctly identify that the point corresponded to the child,s ...
... Life Care Centers ... 21., at its headquarters in Cleveland, Tenn. , ... Cleveland, Tenn. (Vocus) September 28, 2009 -- Life Care Centers of America ... its headquarters in Cleveland, Tenn., , ,The Chairman,s Award for outstanding commitment to excellence went ...
... ... a medical conference offered by the American Academy of Environmental Medicine in Phoenix, Arizona, October ... ... allergies have risen 24% among children under 5 years of age and 19% among children ...
... the number of women opting for surgery to remove the healthy ... a lack of evidence that the surgery can improve survival. The ... choose to have both breasts removed because of a strong family ... and has changed little in the last decade. The study appears ...
... Take precautions to avoid falls, strains and sprains, experts ... health and safety precautions when raking leaves, cleaning gutters ... according to the American Academy of Orthopaedic Surgeons (AAOS). ... the autumn season, and it often takes a toll ...
Cached Medicine News:Health News:Sogeti USA Grows to Ensure Industry Expertise for Clients 2Health News:Sogeti USA Grows to Ensure Industry Expertise for Clients 3Health News:Children's Growth Charts Don't Measure Up With Parents 2Health News:Children's Growth Charts Don't Measure Up With Parents 3Health News:Life Care Centers of America Awards Excellence 2Health News:Life Care Centers of America Awards Excellence 3Health News:Body Under Siege: Inflammation and Autoimmunity Conference Offered to Physicians 2Health News:Body Under Siege: Inflammation and Autoimmunity Conference Offered to Physicians 3Health News:Body Under Siege: Inflammation and Autoimmunity Conference Offered to Physicians 4Health News:More women choosing to remove healthy breast after cancer diagnosis 2Health News:Autumn Chores Often Hazardous 2
(Date:7/30/2014)... July 30, 2014   Bluegrass Vascular Technologies ... innovating lifesaving devices and methods for vascular access, ... Series A financing, which was led by ... deal will allow Bluegrass Vascular to obtain CE ... enhance manufacturing capabilities, and proceed with US regulatory ...
(Date:7/30/2014)... Nev. , July 30, 2014  PDL BioPharma, ... that company management will participate in the Jefferies 2014 ... , Massachusetts. The conference will occur on August 6, ... PDL BioPharma, Inc. PDL BioPharma manages a ... its Queen et al. antibody humanization patents and license ...
(Date:7/30/2014)... 30. Juli 2014 Die Apex ... Anbieter im Bereich Atemtherapie- und Druckzonenprodukte, gibt ... München in Deutschland anfechten werden. Dieses hat ... ein Patent von ResMed verletze. Apex weist ... Ländern gegen verschiedene Patente von ResMed Anfechtungen ...
Breaking Medicine Technology:Bluegrass Vascular Technologies Raises $4.5M Series A Financing Led By Targeted Technology Funds 2PDL BioPharma to Participate in Jefferies 2014 Boston Healthcare Summit 2Apex setzt seinen Kampf gegen Patente für einen freien Wettbewerb fort 2Apex setzt seinen Kampf gegen Patente für einen freien Wettbewerb fort 3
... and Potentially Suited for Once,Daily Administration, PRINCETON, ... an innovator in the discovery and development ... results,from the initial Phase 1 clinical trial ... for the treatment of hypertension,and diabetic nephropathy. ...
... for potential combination,therapies and details of N3/4A ... April 11, 2007 /PRNewswire-FirstCall/ --,InterMune, Inc. announced ... vitro experiments concerning its HCV protease inhibitor,ITMN-191, ... at the 42nd,Annual Meeting of the European ...
Cached Medicine Technology:Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 2Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 3Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 4Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 5InterMune Presents Research on ITMN-191 in Hepatitis C at EASL,Annual Meeting 2InterMune Presents Research on ITMN-191 in Hepatitis C at EASL,Annual Meeting 3InterMune Presents Research on ITMN-191 in Hepatitis C at EASL,Annual Meeting 4
The OX-2 is configured asstandalone or handheld unit, designed for hospital, transport and home use....
Rad-9™...
... 8600 Series Tabletop/Portable Digital Pulse ... tool for patient monitering. From ... the 8600 has earned the ... and is recognized for its ...
... Medicals ONE™ technology is the ... uses a patented digital sensor ... an analog sensor. Dolphin ONE™ ... the signal in the sensor, ...
Medicine Products: