Navigation Links
Clinical studies in the pipeline: the therapies of tomorrow in trials today
Date:10/23/2007

cancer drug in patients, and may have even more benefit when combined with the drug erlotinib (Tarceva), say researchers from OSI Pharmaceuticals, Inc.

OSI-906 is the first small molecule that selectively targets the IGF-1R receptor to enter Phase I trials − two multi-center dose escalation studies of patients with advanced solid tumors.

The researchers offer their first presentation of the agents structure and preclinical pharmacology at the 2007 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics meeting.

The insulin-like growth factor receptor (IGF-1R) is an enzyme expressed on the surface of many human cancer cells, and is known to be a driver of tumor growth. OSI-906 blocks IGF-1R activation of the key cancer cell signaling pathways AKT and MAP kinase, researchers say. In laboratory studies of 28 human tumor cell lines, OSI-906 reduced growth of 15 cell lines representative of colorectal, lung, breast, pancreatic, and pediatric tumors and in mouse models. OSI-906 was particularly effective against tumors that are highly IGF-dependent such as colorectal cancers. According to the researchers, OSI-906 not only slowed tumor growth in mice, but decreased the size of some pre-existing tumors.

Blocking IGF-1R may not always be enough because cancer cells can use other receptors to grow, especially the epidermal growth factor receptor (EGFR) which is known to be activated in many human cancers, said Jonathan Pachter, Ph.D., senior director of Cancer Biology at OSI Pharmaceuticals, Inc. Therefore, we hypothesized that the combination of OSI-906 to block IGF-1R together with the anticancer drug Tarceva, which blocks EGFR, would lead to even more effective reduction of cancer growth in cellular and animal models.

In mice with human colorectal cancer tumors, oral administration of OSI-906 or erlotinib alone significantly reduced further growth of the tumors. But when the two drugs were combined, tumor growth was f
'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. How do patients benefit of clinical trials
2. Magnetic resonance angiography in clinical medicine
3. Clinical trials need to be more frank
4. AEternas acquisition of Zentaris being followed up with its new product pipeline and clinical development strategy
5. Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses
6. The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics
7. Clinical Comparisons Between ADHD Drugs Are Less
8. Outsourcing clinical trials to India
9. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
10. India to maintain Public domain Registry database of clinical trials conducted in India.
11. A Novel System For Clinical Banking Of Umbilical Cord Blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Rosa, CA (PRWEB) December 19, 2014 ... and 5x5 SuperClone Rooms. SuperCloset continues to offer indoor ... solutions. Pair one of the new SuperClone Rooms with ... professional, perpetual, and turnkey indoor hydroponic grow room setup. ... in the world, SuperCloset’s SuperPonic SuperCloner 50 . ...
(Date:12/19/2014)... 2014 These vanadium reserves are mostly ... Around 151,000 tons of vanadium were produced globally in ... usage increased at 6.7% AAGR during the period from ... industry, being the largest consumer, accounted for more than ... titanium-vanadium alloy and the chemical industry. , View Full ...
(Date:12/19/2014)... The Medspa at Hendrick in Abilene, TX ... cosmetic brand Juvéderm. Voluma XC treats volume loss in ... at Hendrick is pleased to be able to offer ... its clients. , Voluma is the first and only ... the mid-face and cheek area. This non-invasive treatment targets ...
(Date:12/19/2014)... 19, 2014 (HealthDay News) -- New research warns parents that buying ... at risk. Nearly half of teen drivers killed in the ... at least 11 years old and often lacked important safety features ... percent of teen drivers killed in crashes were in cars at ... 10 years old, 31 percent were in cars 11 to 15 ...
(Date:12/19/2014)... News) -- All children should have their eyesight checked ... year, eye experts say. The new vision-screening guidelines ... the U.S. National Center for Children,s Vision Health. ... require screening for eye problems, particularly vision issues ... eye") and strabismus (a disorder of eye alignment). ...
Breaking Medicine News(10 mins):Health News:SuperCloset Continues to Innovate with New Complete Indoor Grow Room Packages, The SuperClone Rooms are the Newest Addition to the Award Winning SuperRoom Lineup 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3Health News:Breakthrough New Injectable Dermal Filler Voluma XC Offered by The MedSpa at Hendrick 2Health News:Older Cars a Bad Choice for Younger Drivers 2Health News:Preschoolers Need Eye Screening, Experts Say 2
... making music is what helps relieves his tensions. The ... battle with estranged wife Heather Mills insisted that his ... ,"I don't see it as anything to do ... The singer, songwriter and multi-instrumentalist whose latest album, 'Memory ...
... With its emergency health care services available across most of ... initiative of Satyam Foundation, plans to cover the entire ... country in the next two years. ,EMRI, which ... a population of 65 million in 19 districts. It aims ...
... be creeping up slowly and has touched almost 12%, which ... recorded in 1992. This was reported on Thursday by the ... that if the trend continues, the nation could surpass the ... ,From 1969 until 1992, the rate of accidental deaths ...
... and KENILWORTH, N.J., Centocor, Inc. and Schering-Plough Corporation ... has approved a new indication for REMICADE(R) ... Crohn's disease (CD) in pediatric patients aged 6 ... conventional therapy including a corticosteroid, an immunomodulator and ...
... per patient could spare 30 millions poor people, many ... epilepsy, a new study released Friday has found . ... the developing world go without any treatment whatsoever because ... impede the terrible seizures associated with the illness. ...
... 15 million dollars worth of anti-retroviral drugs from the ... and AIDS, officials announced . Under the deal, the ... for 40,000 people as well as HIV rapid test ... Parirenyatwa commended the donation by the US government, which ...
Cached Medicine News:Health News:EMRI to Expand Emergency Care Services Throughout India 2Health News:The Rate of Accident Deaths Much Higher 2Health News:Remicade(R) Get Approval for First and Only Biologic Treatment for Pediatric Crohn's Disease 2Health News:Small Change Could Stop Epilepsy Seizures for Millions 2Health News:Zimbabwe Receives 15m Dollars of AIDS Drugs from US 2
(Date:12/17/2014)... and RALEIGH, N.C. , Dec. ... LLC (CTMC), and Integrated Clinical Trial Services, LLC ... retention for clinical trials announce that they have ... Marketing Services (i-CTMS). i-CTMS will provide a broad ... pharmaceutical, biotechnology and medical device companies. ...
(Date:12/15/2014)... December 15, 2014 ... 19. und 20. Februar sind alle akkreditierten ... MEDICINE ECOSYSTEM PARTNER PROGRAMM ™ 2015 in ... Diese Tagung soll dazu beitragen, ... geben, die neue profitablen Unternehmensdienstleistungen, die für ...
(Date:12/15/2014)... 12, 2014 Research and Markets ( ... "Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram Devices ... 2016. The North America accounts ... while Europe claims approximately 27% ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Symposium über Aegates Ecosystem-Partner-Programm für sichere Medikamente vom 19. - 20. Februar 2015 in Amsterdam 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4
Carbo-Seal Valsalva AAP is the first valved graft to replicate the natural Sinus of Valsalva, encouraging the natural formation of systolic vortices....
Current annuloplasty rings and bands are designed for symmetric dilatation. The IMR ETlogix ring is the first asymmetric ring designed to treat asymmetric dilatation....
PremierEdge™ Stab Knives - 30°....
Lacrimal Intubation Set w/Retrieval Device. Size: Probes 23g x 4-1/4"....
Medicine Products: