Navigation Links
Clinical studies in the pipeline: the therapies of tomorrow in trials today
Date:10/23/2007

conclusion concerning the efficacy of interleukin-21 in combination with sorafenib compared to use of sorafenib alone, he said. To date, most adverse events seen have been mild and moderate, Dr. Thompson adds.

Because the two drugs work in very different ways and both have low toxicity profiles, the researchers predicted they would have additive or even synergistic effects when used in combination. Pre-clinical studies in mice showed that, indeed, the two together work better than either alone, Dr. Thompson says.

Sorafenib, a tyrosine kinase inhibitor approved for use in December 2005 under the trademark Nexavar, blocks enzymes in cancer cells that promote tumor growth and also blocks blood vessel growth in tumors, thereby depriving the tumor of nutrients and oxygen. Although sorafenib does not typically cause a large shrinkage of the tumor, it can prevent the tumor from growing further, and has been shown to delay the progression, or growth, of kidney cancer, Dr. Thompson said.

Recombinant IL-21 activates the immune system to kill cancer cells. Immune therapies have been shown to work in kidney cancer in the past, but those previously available were very toxic and poorly tolerated by most patients. Recombinant IL-21 is well tolerated by most patients, Dr. Thompson said. In our clinical trial of recombinant IL-21 by itself, we saw encouraging responses in patients with kidney cancer.

Therefore, treatment with sorafenib may make the cancer more susceptible to a killing response by an activated immune system, he says. We are looking forward to the Phase II portion of the study to better evaluate the overall safety profile and anti-tumor activity, Dr. Thompson said.

Preclinical characterization of OSI-906: A novel IGF-1R kinase inhibitor in clinical trials: Number C192

Preclinical studies suggest that a small molecule inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) may be an effective anti
'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. How do patients benefit of clinical trials
2. Magnetic resonance angiography in clinical medicine
3. Clinical trials need to be more frank
4. AEternas acquisition of Zentaris being followed up with its new product pipeline and clinical development strategy
5. Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses
6. The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics
7. Clinical Comparisons Between ADHD Drugs Are Less
8. Outsourcing clinical trials to India
9. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
10. India to maintain Public domain Registry database of clinical trials conducted in India.
11. A Novel System For Clinical Banking Of Umbilical Cord Blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... OH (PRWEB) September 22, 2014 A ... 2014, to set up the discovery phase for testosterone ... District Court, Northern District of Illinois. Wright & ... until mid October to submit initial disclosures about potential ... further instructed attorneys to continue negotiating the topics in ...
(Date:9/21/2014)... Dry Face Brushing brings benefits to facial ... Dry Brushing improves blood circulation and tone, feeding nutrients to ... toxins and debris from the skin , 3) Dry Face ... Body Brushing can and should be done daily, there are ... fragile and thinner, it needs less. Normal, dry and ...
(Date:9/21/2014)... a partial smoking ban at a homeless shelter can ... an indicator of exposure to cigarette smoke, and may ... new research. The University of Texas Health Science Center ... in the journal Addictive Behaviors . , The ... to 18 percent among adults, but among homeless adults, ...
(Date:9/21/2014)... on the physical activity benefits of active play, a ... for children, playing has no goal it is ... done alone or with friends, and it represents "an ... combat boredom, sadness, fear, or loneliness." "By focusing on ... several aspects of play that are beneficial to young ...
(Date:9/21/2014)... 2014 Burnaby Physiotherapists at Absolute PhysioCare ... in order to help them with preventative care. This ... clinic that will help clients understand their problem in ... active participation in the healing process. With higher knowledge ... be able to facilitate the therapy that is initiated ...
Breaking Medicine News(10 mins):Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 2Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 3Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 4Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 5Health News:Gorgeous Skin: 3 Top Benefits of Dry Face Brushing from Sublime Beauty® 2Health News:UTHealth researchers study impact of smoking ban in homeless shelter 2Health News:Narrow focus on physical activity could be ruining kids' playtime 2Health News:Burnaby Physiotherapists Now Provide Educational Information for Preventative Care 2
... 2009 As soccer continues to grow in popularity, injuries ... Certain injuries fall into gender-based patterns and new ... causes that could help lead to better treatment, or ... Data presented at this year,s American Orthopaedic Society for ...
... MAP Pharmaceuticals, Inc. (Nasdaq: MAPP ) today announced ... license agreement with AstraZeneca related to the company,s Unit Dose ... July 8, 2009, effective immediately. All rights licensed to ... MAP Pharmaceuticals plans to suspend development of UDB, which did ...
... New Zealand, July 9 ZyGEM Corp. Ltd., a ... other life sciences applications, today announced the availability of ... GEM(R) Bacteria DNA extraction kit is capable of producing ... bacterial species, including mixed or unknown sample types. ...
... Tested on animals, liquid would be administered externally , ... developed a pain-free vaccination that might thwart ear infections ... ear infections, and surgery is often recommended for children ... microorganisms and the invasive nature of the surgical procedure ...
... July 9 Universal Health Services, Inc. (NYSE: ... to pay a cash dividend of $0.08 per share on ... 1, 2009. , , Universal Health Services, Inc. is ... subsidiaries, acute care and behavioral health hospitals, and ambulatory centers ...
... , TAMPA, Fla., July 9 With healthcare ... chairman and chief executive officer of Health Integrated, a leading ... for companies that can clearly offer solutions to drive down ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20090709/FL43703LOGO ...
Cached Medicine News:Health News:Motion analysis helps soccer players get their kicks 2Health News:Motion analysis helps soccer players get their kicks 3Health News:MAP Pharmaceuticals Announces Termination of Pediatric Asthma Collaboration 2Health News:MAP Pharmaceuticals Announces Termination of Pediatric Asthma Collaboration 3Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 2Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 3Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 4Health News:Vaccine May Someday Thwart Ear Infections 2Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 2Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 3Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 4Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 5
(Date:9/19/2014)... Sept. 19, 2014 Research and Markets ... (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast ... the purposes of this report, the human microbiome market is ... human microbiome market is expected to be valued as $294 ... CAGR of 22.3% within the forecast period of 2019-2023. The ...
(Date:9/19/2014)... 19, 2014 Five MinuteClinic walk-in medical clinics are opening ... metropolitan area. Three clinics opened in Memphis ... clinic will be added in Springfield on ... is expected to open October 22.  MinuteClinic is the largest ... the United States . The Memphis ...
(Date:9/19/2014)... DIEGO , Sept. 19, 2014  Lpath, ... leader in bioactive lipid-targeted therapeutics, announced today that ... 3,605,042 registered shares of common stock and 3,605,042 ... combined purchase price for one registered share of ... one unregistered share of common stock will be ...
Breaking Medicine Technology:Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Lpath, Inc. Announces $12.5 Million Registered Direct Offering 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 3
... closes various plastic primary and secondary tubes in ... heights and diameters can be sealed in one ... send-outs. The integration into other PVT Systems (e.g. ... and High Throughput Sorter RSD ProVolume ) ...
... MGB Alert Detection Reagents provide molecular ... PCR based assays. By using our MGB ... analysis, Nanogen is now able to provide ... nucleic acid sequences of specific organisms or ...
... for the detection of two genetic ... mutation on the Factor V (Leiden) ... the Prothrombin gene. Laboratories may use ... *Analyte Specific Reagents. Analytical ...
... the latest and most advanced fecal occult ... line. An immunochemical FOBT (iFOBT) with high ... proven to detect bleeding associated with more ... Because of its superior specificity for lower ...
Medicine Products: