Navigation Links
Clinical studies in the pipeline: the therapies of tomorrow in trials today
Date:10/23/2007

itinib may indeed target key angiogenesis pathways in relevant cell populations.

These are very interesting changes in blood markers induced by sunitinib. Ongoing studies of these and of other markers might help us to understand how the drug works in HCC and what changes might be relevant in predicting the potential clinical benefits in these patients, Dr. Zhu said.

The Harvard Medical School research team involved in this study includes Dushyant Sahani, M.D., and Rakesh K. Jain, Ph.D. The study was funded by Pfizer, Inc., manufacturers of sunitinib (marketed as Sutent).

Recombinant IL-21 in combination with sorafenib: Preliminary results from a phase I/II study in patients with metastatic renal cell cancer: Abstract A 60.

Two drugs appear to work better than one in treatment of patients with metastatic kidney cancer, according to early results from the first and only clinical trial testing a combination of sorafenib and recombinant interleukin-21.

Among 11 patients with renal cell carcinoma who have gone on to have two or more rounds of combination treatment, 10 have experienced tumor shrinkage, and four patients have had 30 percent or greater reduction in tumor size as measured by the investigators. A total of 13 patients have been enrolled so far in this Phase I study, which is testing three different dose levels.

These preliminary data are encouraging, as treatment with sorafenib alone was associated with a confirmed overall response rate of only two percent in the Phase III trial that led to regulatory approval, said the studys lead investigator, John A. Thompson, M.D., a professor of medicine at the University of Washington and a member of the Fred Hutchinson Cancer Research Center. The study was funded by Zymogenetics, which developed recombinant interleukin-21 (IL-21).

However, at this point the number of patients treated in our study is still small and it is too early to draw a definite
'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. How do patients benefit of clinical trials
2. Magnetic resonance angiography in clinical medicine
3. Clinical trials need to be more frank
4. AEternas acquisition of Zentaris being followed up with its new product pipeline and clinical development strategy
5. Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses
6. The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics
7. Clinical Comparisons Between ADHD Drugs Are Less
8. Outsourcing clinical trials to India
9. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
10. India to maintain Public domain Registry database of clinical trials conducted in India.
11. A Novel System For Clinical Banking Of Umbilical Cord Blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... As one of only 30 Illinois ... and Health Achievement and Recognition Program (SHARP) certification, ... by the Illinois Department of Labor to host this ... SHARP certification by the Occupational Safety and Health Administration’s ... continued to meet or exceed all of the necessary ...
(Date:5/2/2015)... Vancouver fencing company, QS Fencing, has recently announced that its ... related to their questions on railings and gates. Many people ... and patios. While that seems like an easy task, there ... rolls up their sleeve to start working. One of the ... gate that matches it. , Instead of spending hours worrying ...
(Date:5/2/2015)... ProText Kinetic 2 is a set of typography ... X. ProText Kinetic 2 features 40 animation presets ... X . Easily create interactive text videos without having ... Kinetic 2. , Using ProText Kinetic is as easy as ... presets in the FCPX timeline. Playback the default animation ...
(Date:5/2/2015)... 2015 We are pleased to announce ... Center as one of the Top Workplaces of 2015. ... addiction treatment field for their ethics and standards of ... to continue their educational efforts. The Delray Recovery Center ... forgetting their purpose – to help individuals heal from ...
(Date:5/2/2015)... On Tuesday April 7th, the patient ... to celebrate improvements in patient care. In 2014 the ... had zero acquired ventilator associated infections, zero central line ... was also recently named a Top Performer by the ... credited the teamwork of staff from all departments involved ...
Breaking Medicine News(10 mins):Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2
... going blind and not know it. Silently, without symptoms, Glaucoma ... ,January is Glaucoma Awareness Month, and the American Academy ... urges everyone to get a complete eye exam, especially if ... ,* African-Americans older than 40 ,* Hispanics ,* People with ...
... long been associated with an increased risk of injury ... says a recent study// by a University of Missouri, Columbia. ... Vinson, professor of community and family medicine, found that patients ... injured. However, patients who reported better sleep quality in the ...
... New research published in the Jan. 10 issue of ... University chemists// and North Carolina State University toxicologists, finds ... ,This research was based on the ... buckyball-containing amino acids. "Our results confirm that repetitive ...
... new software-based approach to detect osteoporosis while doing routine ... width of a part of the patient`s lower jaw. ... at the University’s School of Dentistry adapted the ‘active ... of Imaging Sciences and use it to automatically detect ...
... younger someone starts drinking alcoholic beverages, the more likely ... to relieve stress when older, a large new study ... among persons who started drinking at 14 or younger ... drinking are already higher than those of other drinkers,” ...
... undergone a hip replacement surgery and is resting comfortably//. ... the Mayo Clinic in Rochester, Minnesota said on its ... of the current president. His surgery came two days ... of former president Gerald Ford, who died Dec 26 ...
Cached Medicine News:Health News:Glaucoma: Silently Stealing Sight from Millions 2Health News:A Study Explores the Medical Potentials of Bucky Amino Acids 2Health News:Youngest Drinkers Likelier to Use Alcohol for Stress Relief as Adults 2
(Date:5/1/2015)... REDWOOD CITY, Calif. , May 1, 2015  AcelRx ... company focused on the development and commercialization of innovative ... today announced that Timothy E. Morris , chief ... events.  Details of the events are as follows: ... Tuesday, May 5 Location:  The Omni Berkshire Place, ...
(Date:4/30/2015)... ON , April 30, 2015 /PRNewswire/ - ... specialty pharmaceutical company with a focus on Omega-3 ... announced its operational highlights and financial results for ... dollar amounts referenced herein are in Canadian dollars ... 2014 have been significant, with the right strategic ...
(Date:4/30/2015)... SUNNYVALE, Calif. , April 30, 2015 /PRNewswire/ ... that it has signed an agreement with MIM ... for the TomoTherapy ® and CyberKnife ® ... both Accuray and MIM technology. This is Accuray,s ... to the development of the first iPad-based treatment ...
Breaking Medicine Technology:AcelRx Pharmaceuticals to Participate at Upcoming Investor Conferences in May 2Pivotal Therapeutics Announces 2014 Financial Results 2Pivotal Therapeutics Announces 2014 Financial Results 3Pivotal Therapeutics Announces 2014 Financial Results 4Pivotal Therapeutics Announces 2014 Financial Results 5Pivotal Therapeutics Announces 2014 Financial Results 6Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3
... , , ... SILVER SPRING, Md. , Jan. 18 The ... a counterfeit and potentially harmful version of Alli 60 mg ... ) , Preliminary laboratory tests conducted by GlaxoSmithKline (GSK) -- ...
... , Kidney Care Partners, Members Provide Dialysis Equipment, ... Access to Life-Saving Treatment , PORT-AU-PRINCE, Haiti ... an earthquake that has devastated this Caribbean country, ... of millions of dollars as well as dialysis equipment, medications, ...
Cached Medicine Technology:FDA Warns Consumers about Counterfeit Alli 2FDA Warns Consumers about Counterfeit Alli 3U.S. Kidney Dialysis Community Responds to Haiti's Emergency Plea for Life-Saving Dialysis Care 2U.S. Kidney Dialysis Community Responds to Haiti's Emergency Plea for Life-Saving Dialysis Care 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: