Navigation Links
Clinical studies in the pipeline: the therapies of tomorrow in trials today
Date:10/23/2007

SAN FRANCISCO Studies presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics demonstrate the flexibility of targeted therapy techniques, where new drugs can be developed and tested in human trials more quickly and safely than ever before.

Among the studies presented include a pair of reports on two separate novel insulin-like growth factor receptor enzyme inhibitors, both currently involved in solid tumor clinical trials. In addition, researchers will be offering details on two Phase II trials involving already-approved drugs in new applications: sunitinib in a form of liver cancer and sorafenib, combined with the cell-signaling molecule IL-21, in metastatic renal cancer.

Efficacy, safety, and changes in angiogenic markers following sunitinib monotherapy in patients with advanced hepatocellular carcinoma: Experience from a phase II study: Abstract PR 7.

Use of sunitinib, designed to reduce tumor angiogenesis, appears to offer early evidence of antitumor activity for patients with a difficult to treat liver cancer known as advanced hepatocellular carcinoma (HCC), say researchers at Dana Farber Harvard Cancer Center.

Results from a 30-patient Phase II study in HCC of the agent, which is approved for use in kidney and rare stomach cancers, show that cancer stabilized in 10 patients for at least three months while one patient had a partial response. Overall, the agent offered a progression-free survival of four months, says the studys lead investigator, Andrew X. Zhu, M.D., Ph.D., an attending oncologist at Massachusetts General Hospital Cancer Center and an assistant professor of medicine at Harvard Medical School.

We have seen preliminary evidence of anti-tumor activity, and although it is modest, it is also encouraging because all of these patients have cancer that cannot be removed by surgery or which has metastasized, Dr. Zhu said. This is a small, single a
'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. How do patients benefit of clinical trials
2. Magnetic resonance angiography in clinical medicine
3. Clinical trials need to be more frank
4. AEternas acquisition of Zentaris being followed up with its new product pipeline and clinical development strategy
5. Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses
6. The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics
7. Clinical Comparisons Between ADHD Drugs Are Less
8. Outsourcing clinical trials to India
9. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
10. India to maintain Public domain Registry database of clinical trials conducted in India.
11. A Novel System For Clinical Banking Of Umbilical Cord Blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... August 01, 2014 Get the report ... with PitchBook presents the 3Q 2014 Private Equity Breakdown ... equity investment, exits and fundraising activity in the second ... help plan for private equity endeavors for the remainder ... to download it now. , About Merrill DataSite , ...
(Date:8/1/2014)... iFitDress.com, a professional company of women’s dresses and ... silver bridesmaid dresses recently. All of these ... fashion trends. What’s more, they are now offered at ... , iFitDress.com is one of the leading suppliers in ... bridesmaid gowns, but also many other kinds of beautiful ...
(Date:7/31/2014)... 2014 The 2013 edition of ... chemical listings, appellate decisions, litigation and settlement trends, ... compliance with California's Proposition 65. , The Handbook ... regulations, history and trends impacting California's Proposition 65. ... of the series which adds approximately 200 pages ...
(Date:7/31/2014)... (August 1, 2014) Women over the age of ... risk for obesity, greater struggles against poverty and higher ... published in the August issue of Annals of ... the American College of Allergy, Asthma and Immunology (ACAAI), ... asthma, and offers practical solutions to improve their care. ...
(Date:7/31/2014)... birth control pills containing high-dose estrogen and a few ... whereas women using some other formulations did not, according ... journal of the American Association for Cancer Research. , ... [birth control pills] in the past year is associated ... or former oral contraceptive use, and that this risk ...
Breaking Medicine News(10 mins):Health News:Register to Download Merrill DataSite's Report: PitchBook 3Q 2014 Private Equity Breakdown Report 2Health News:iFitDress.com: Beautiful Silver Bridesmaid Dresses at Promotional Prices 2Health News:Save 25% on the Proposition 65 Handbook - 2013 Edition Through August 31 2Health News:Female baby boomers with asthma? You may need help 2Health News:Female baby boomers with asthma? You may need help 3Health News:Recent use of some birth control pills may increase breast cancer risk 2
... scientists at SUNY Downstate Medical Center in Brooklyn and ... patent for their virtual telemicroscope. This patented software permits ... patients living in remote locations around the world. ... pathology at SUNY Downstate, and Jiang Gu, MD, PhD, ...
... on investigations, -- Three-fifths want high school ... stats and awards from guilty pro,athletes, FAIRFIELD, ... Baseball season-opener approaches, a new national poll,indicates that ... use among,professional athletes., On average, Americans polled ...
... DIEGO, March 27 Gen-Probe Incorporated,(Nasdaq: GPRO ) ... Leerink,Swann "Bugs and Drugs: The Future of Molecular Diagnostics ... approximately 1:20 p.m. Eastern,Time. The presentation is scheduled to ... on the investor information section of Gen-Probe,s website,at ...
... physical disability does, study shows , , THURSDAY, March 27 (HealthDay ... almost as often as physical disability does, Australian researchers report. ... 55, who had paying jobs before a stroke found that ... about the same ratio as in a recent U.S. study, ...
... 27 The Anthem Blue Cross and Blue Shield,Foundation announced ... San Luis,Valley Chapter of the American Red Cross to assist ... bottles, formula and water,and to aid volunteers who are distributing ... been affected by the recent Salmonella water,contamination., "One of ...
... dairy cow is back at her Kansas farm ... surgery performed at Kansas State University,s,Veterinary Medical Teaching ... the veterinary students assigned to,her case, sustained a ... in her right knee ruptured. Dr. David Anderson, ...
Cached Medicine News:Health News:SUNY researcher issued patent for virtual telemicroscope 2Health News:Americans Guess One-Third of Professional Athletes on Performance Enhancing Drugs 2Health News:Americans Guess One-Third of Professional Athletes on Performance Enhancing Drugs 3Health News:Gen-Probe to Webcast Presentation at Leerink Swann Molecular Diagnostics Conference 2Health News:Depression After Stroke Can Be Debilitating 2Health News:Anthem Blue Cross and Blue Shield Foundation Donates $7,500 to San Luis Valley American Red Cross to Assist Residents Affected by Water Contamination Crisis 2Health News:'Wildcat Power Cord' Repairs Cruciate Ligament in Dairy Cow's Knee 2Health News:'Wildcat Power Cord' Repairs Cruciate Ligament in Dairy Cow's Knee 3
(Date:7/31/2014)...  Cepheid (NASDAQ: CPHD ) today announced that ... invited investors to participate via webcast. ... NY Wednesday, August 13, 2014 at 9.10 a.m. ... New York, NY Thursday, September 4, 2014 ... Webcasts To access the live webcasts for these events, please ...
(Date:7/31/2014)...   Auxilium Pharmaceuticals , Inc. (NASDAQ: ... announced that the Company will release results for the ... before the opening of the U.S. financial markets. The ... at 8:30 a.m. ET to discuss results and highlights ... to be used during the call will be available ...
(Date:7/31/2014)... 2014  Decision Resources Group,s experts are ... the Affordable Care Act (ACA), which has ... therapies. The ACA altered how Managed Care ... and expanded access via government-supported programs. Dynamic ... marketplaces set up by states or the ...
Breaking Medicine Technology:Cepheid to Webcast Upcoming Financial Presentations 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 2Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 4
... Neuralstem, Inc. (NYSE Alternext US: CUR) announced today ... ALS is on clinical hold and that the ... with specific comments, questions and recommendations for modifications ... has presented us with their review of our ...
... Calif., Feb. 20 /PRNewswire-FirstCall/ -- Pharmacyclics (Nasdaq: ... a financing in connection with an investment by the ... San Bruno California and Taizhou, Jiangsu Province, People,s Republic ... $1.4 million dollar private investment into Pharmacyclics at $0.93/share. ...
Cached Medicine Technology:Neuralstem's ALS Trial on Clinical Hold 2Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd. 2Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd. 3
... industry:, ,AirSeps AirLife On-board Oxygen Concentrators ... their supplemental oxygen passengers and are still ... With the US governments FAA/STC approval for ... Boeing commercial aircraft, AirSep set the standard ...
... Specifications, including colors, subject to change. , ... kg), FreeStyle by AirSep is the only ... patients who know no boundaries. Bold and ... the heart of what it means to ...
... Portable Oxygen Concentrator is the most compact, ... 10 lbs (4.5 kg), this unit was ... highly active oxygen patient., ,Operating as ... technologies of both an oxygen concentrator and ...
... Has improved the quality of life for ... providers a quality product designed with state-of-the-art ... less than 50 pounds can operate through ... of coverage warranties. The M600/605 series with ...
Medicine Products: