Navigation Links
Clinical insight improves treatment with new lung cancer drug
Date:4/4/2012

AURORA, Colo. (April 4, 2012) - Men experience a marked drop in their testosterone levels when taking a targeted therapy to control a specific type of lung cancer. That's according to a University of Colorado Cancer Center study published in the April issue of Cancer, the official journal of the American Cancer Society.

Investigators at CU Cancer Center looked at the hormone levels in men with anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC) taking crizotinib, after a 35-year-old man on the drug reported symptoms that are often attributed to low testosterone levels: fatigue and sexual disinterest.

Crizotinib tablets were licensed by the Food and Drug Administration in August 2011, because of its dramatic and long-lasting suppression of ALK positive lung cancer. ALK positive lung cancer was only recently described so very few cancer centers have a lot of experience identifying and treating this subtype of the disease. CU Cancer Center was involved in the initial development of the drug and has treated one of the largest groups of ALK positive patients in the world.

The testosterone study included 19 men with lung cancer taking crizotinib and 19 men with lung cancer receiving other kinds of therapy. Andrew Weickhardt, MD, senior clinical fellow at the CU Cancer Center, and one of the study's co-authors said listening to the specific issues of that one young man, and a growing awareness of the incidence of low testosterone in cancer patients, made investigators look more closely at their patient population.

"While testosterone was low in only about thirty percent of men on other therapies, it was low in one hundred percent of the men who were on crizotinib. And when we started to track it over time, we could clearly see testosterone levels dropping within days of starting on the drug," said Weickhardt.

As men may stay on crizotinib for months, or even years, the effects of lo
'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-524-2780
University of Colorado Denver
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. First targeted nanomedicine to enter human clinical studies
2. Early clinical data show galeterone safe, effective against prostate cancer
3. Stephanie R. Wilson, MD, to be presented with the Joseph H. Holmes Clinical Pioneer Award
4. Standardized outcome measures proposed for asthma clinical research
5. NYU Langone orthopaedic experts present research, clinical advances at AAOS meeting
6. Large hospital successfully implements CPOE system with clinical decision support for radiology
7. New target for cancer therapy identified, preclinical study shows
8. NIH to join multi-center clinical trial of new tuberculosis vaccine
9. Parkinsons treatment shows positive results in clinical testing
10. Kessler Foundation and USC collaborate on clinical virtual reality for disability research
11. Clinical trial demonstrates that rilonacept significantly reduces gout flares
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... Many orthodontists have thought about moving their office to ... Most people would naturally assume that the company ... service and support would own and maintain all the ... be wrong. Cloud providers lease space in a ... houses servers and related equipment to run cloud environments) ...
(Date:5/25/2013)... Vancouver, BC (PRWEB) May 25, 2013 ... of the most beautiful and powerful women that ever ... was felt by some of the most powerful men ... used many beauty remedies to keep her skin glowing ... treatments made with bees- wax, maringa oil and cyprus ...
(Date:5/25/2013)... May 25, 2013 The Slim Weight Patch ... and results. This is due to the highly sought after ... Slim weight patch offers an extra 2 months supply & ... goals and get the body you desire faster than ever. ... Website , With Slim weight patch consumers can observe ...
(Date:5/25/2013)... 25, 2013 Prairie Living at ... hosting an American Red Cross Blood Drive from 1:30 ... community, which is located at 955 Villa Ct. in ... those on Medicaid, who need some help to maintain ... Life," says Andrea Arview Frey, Director of Marketing for ...
(Date:5/25/2013)... (PRWEB) May 25, 2013 Ayurveda ... "knowledge or wisdom of life". While a medical science, its ... transformation of consciousness. Its fundamental philosophy is that disease is ... environment. In order to re-establish optimal health, one must discover ... a life style which brings us back into perfect harmony. ...
Breaking Medicine News(10 mins):Health News:Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 3Health News:Slim Weight Patch Advanced Weight Loss System Offers Extra Two Month Supply and Membership for Maximum Weight Loss 2Health News:Carbondale Affordable Assisted Living Community to Host Red Cross Blood Drive 2Health News:Fundamentos de Ayurveda in Mexico (Ayurvedic Principles) Offered by Escuela de Ayurveda de California 2
... to relieve stress, a common cause of heart ... ... us think,of love and Valentine,s Day. This February, which also is National Heart,Awareness ... your heart. A healthy heart can be attained in a variety,of ways that ...
... PORTLAND, Ore. An Oregon Health & Science University Cancer ... the ability to predict if a mans prostate cancer is ... In order to make this discovery, researchers examined prostate cancer ... cancer patients. The researchers found that men whose tumors showed ...
... course of the presidential nomination campaign, some candidates health ... the phrase socialized medicine has been used to attack ... poll by the Harvard Opinion Research Program at the ... finds that Americans are split on whether a socialized ...
... National Board, KNOXVILLE, Tenn., Feb. 14 ... of Stacy Goldsholl, MD, as an,officer of its ... Medicine, is serving her second consecutive term as ... the premier medical society that,represents hospitalists. Hospital medicine ...
... (Nasdaq: DATA ), a technology company focused ... today reported that it will be,presenting at the ... at the Ritz Carlton in Laguna Niguel, California, ... on Wednesday afternoon,February 20th at 2:30 P.M., Pacific ...
... researchers from Europe and North America were given important ... national boundaries at a two-day training course in Croydon, ... Foundation as part of its Pan-European Clinical Trials (ECT) ... trials with a specific focus on the Euramos trial ...
Cached Medicine News:Health News:Healthy Heart, Healthy Home 2Health News:OHSU cancer institute researcher discovers new predictor of prostate cancer recurrence 2Health News:Poll finds Americans split by political party over views on socialized medicine 2Health News:Poll finds Americans split by political party over views on socialized medicine 3Health News:Stacy Goldsholl, MD, Re-elected to Board of Society of Hospital Medicine 2Health News:DATATRAK to Present at the Roth Capital Partners 20th Annual Orange County Stock Conference 2Health News:DATATRAK to Present at the Roth Capital Partners 20th Annual Orange County Stock Conference 3Health News:ESF's EMRC strengthens training course on clinical trials management 2
(Date:5/23/2013)... , May 23, 2013  Haemonetics Corporation (NYSE: ... , CFO & EVP-Business Development, will present at The Deutsche ... Boston, MA on May 29, 2013 ... ) The public may access Mr. Lindop,s ... About Haemonetics Haemonetics (NYSE: HAE ...
(Date:5/23/2013)... , May 23, 2013  MGC Diagnostics Corporation (NASDAQ: ... medical technology company, today scheduled a conference call to ... fiscal year 2013, ended April 30, 2013. The call ... 30, 2013. The Company will report financial results for ... markets close on Thursday, May 30, 2013. ...
(Date:5/23/2013)... -- Hadasit Bio-Holdings Ltd. (TASE: HDST, OTC: HADSY), a ... intellectual property developed and owned by Hadassah University ... research center, today announced that its portfolio company, ... the Israeli Ministry of Industry and Commerce, Office ... development and advance clinical trials. Cell Cure,s development ...
Breaking Medicine Technology:MGC Diagnostics Corporation to Report Second Quarter Fiscal 2013 Financial Results on Thursday, May 30, 2013 2Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2
... A Pebble Beach golf tournament pays off big for ... took home the top prize: a $150,000 contribution from multi-platinum ... (BAMS) organization. The money will fund important studies on the ... Health Science Center at Houston . , , (Photo: ...
... LEIDEN, The Netherlands, July 6 ... Synvolux Therapeutics and InteRNA,Technologies - have joined public-private partnership ... focusing on cancer and,inflammatory diseases, have a total budget ... The new consortium, formed by Syncom, Synvolux Therapeutics, ...
Cached Medicine Technology:Clay Walker's Band Against MS Foundation Donates $150,000 To Support Multiple Sclerosis Research 2New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: