Navigation Links
Clinical depression linked to abnormal emotional brain circuits
Date:8/14/2007

impact."

In both healthy and depressed individuals, they found that such efforts increased brain activity in prefrontal cortical areas known to help regulate the emotional centers of the brain, as they expected.

The big difference was seen in the reactions of the emotional centers themselves, including a small almond-shaped structure called the amygdala located deep in the brain. The study appears in the August 15 issue of the Journal of Neuroscience.

In nondepressed individuals, high levels of regulatory activity correlated with low activity in the emotional response centers - in effect, the healthy subjects' efforts successfully quelled their emotional responses. In depressed patients, however, high levels of activity in the amygdala and other emotional centers persisted despite intense activity in the regulatory regions.

This finding suggests that healthy people are able to effectively regulate their negative emotions through conscious effort, but that the necessary neural circuits are dysfunctional in many patients with depression, the researchers say. The difference becomes even more pronounced the harder the patients try.

"Those [healthy] individuals putting more cognitive effort into it are getting a bigger payoff in terms of decreasing activation in these emotional centers," Johnstone explains. "In the depressed individuals, you find the exact opposite relationship - it seems the more effort they put in, the more activation there is in the amygdala."

Though the researchers don't yet know exactly where the differences lie, Johnstone suggests multiple factors may be at work. One possibility is that depressed individuals have a broken link between the brain regions, such that regulatory centers fail to send any dampening signals to emotional centers.

Alternately, he says, depressed patients may fall prey to rumination on negative thoughts. Maybe, he says, "When they try to engage in this regula
'/>"/>

Contact: Tom Johnstone
itjohnstone@wisc.edu
608-263-2743
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. How do patients benefit of clinical trials
2. Magnetic resonance angiography in clinical medicine
3. Clinical trials need to be more frank
4. AEternas acquisition of Zentaris being followed up with its new product pipeline and clinical development strategy
5. Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses
6. The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics
7. Clinical Comparisons Between ADHD Drugs Are Less
8. Outsourcing clinical trials to India
9. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
10. India to maintain Public domain Registry database of clinical trials conducted in India.
11. A Novel System For Clinical Banking Of Umbilical Cord Blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2008)... Check to benefit ALS Therapy Alliance to be pr... Tonight, WOONSOCKET, R.I., July 25 /PRNewswir...it has raised a record-breaking $4.4 million in ju... campaign for ALS research. This is,the seventh ye..., has,raised more than $15 million for ALS researc...
(Date:7/25/2008)... New program delivers imm...nk.html [24-hour telephone access to language int...or seeking multilingual solutions. , ...8 -- -- LLE® http://www.lle-inc.com/index.ht...ding provider of interpretation, translation, and ...
(Date:7/25/2008)... This donation will be us... protective services for children , ...IVCi, LLC ( www.ivci.com ), a leading integrator ...gh definition video conferencing, telepresence, au...ervices, announced today that it has donated video...
(Date:7/24/2008)... WASHINGTON, July 24 /PRNewswire-USNewswire/ --...ment this evening in support of the Tom Lantos,and... Tuberculosis, and,Malaria Reauthorization Act of ... passed the House this evening by a vote of 303 to...re into law., "Today the House took an historic v...
Breaking Medicine News(10 mins):Health News:CVS/pharmacy Raises Record-breaking $4.4 Million for ALS Research Through Annual ALS Fundraising Campaign 2Health News:LLE Launches Over-the-Phone Interpretation OPI Easy Switch Program 2Health News:LLE Launches Over-the-Phone Interpretation OPI Easy Switch Program 3Health News:Mt. Sinai's Children's Trauma Institute Treatment and Service Adaptation Center Receives Video Conferencing Donation From IVCi 2Health News:Pelosi Statement on House Passage of Global AIDS Legislation 2
...ios Spanos was shocked when his doctor discovered ... his body’s largest blood vessel, the aorta, durin...o symptoms, and was relieved to find out that the ...had been caught while it was still small. For the...
... A brewery in Japan launched production of unusual...farmer who was looking for ways to put his milk su...k will be available in the store shelves Thursday,...akashibetsu, on the country's northernmost island ...
... are planning to whiten your teeth by bleaching th...it done by unqualified people could cause consider...alons are offering teeth whitening by unqualified ...l bleach," said Christopher Orr, president of the ...
...tors and nurses who work in the developing world w...challenges, according to ‘Meeting the Health needs... The BMA’s International Committee surveyed 79 UK...including 67 doctors, who had recently worked in A...
Other Medicine News:Health News:Early Detection of Artery Weakening Can Be a Life-Saver 2Health News:Early Detection of Artery Weakening Can Be a Life-Saver 3Health News:Health Workers Need Better Preparation for Developing World 2
(Date:7/24/2008)... July 24 /- Alexza,Pharmace...t it has initiated,its second Phase 3 clinical tri...n inhalation product candidate being developed for... schizophrenia or bipolar disorder.,Alexza believe...okinetic,(PK) properties resulting from inhaled lo...
(Date:7/24/2008)...ewswire-FirstCall/ -- MacroChem Corporation (OTC,B...Phase 2 clinical trial,involving 37 patients who c...efficacy and safety study of EcoNail, a topical an...s (nail fungus). The composite,primary efficacy en...,negative mycology (negative fungal culture and ne...
(Date:7/23/2008)...RNewswire-USNewswire/ -- The following was,release...nyers, Ranking Member Smith, and Members of the Co...today., Since I appeared before this Committee al...uainted with the talented and dedicated profession...ey do, and I have come to,appreciate that much mor...
(Date:7/23/2008)...-Enabling Work with Protein Therapeutics that ...ystem, CAMBRIDGE, Mass., July 23 /- ...nitiated a corporate growth plan with the,appointm...fficer and the,establishment of its headquarters i...Emlen, M.D., a co-founder of the company who remai...
Breaking Medicine Technology:Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 2Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 3Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 4Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 5Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine) 6MacroChem Announces Phase 2 Data for EcoNail(R) in the Treatment of Onychomycosis 2MacroChem Announces Phase 2 Data for EcoNail(R) in the Treatment of Onychomycosis 3MacroChem Announces Phase 2 Data for EcoNail(R) in the Treatment of Onychomycosis 4MacroChem Announces Phase 2 Data for EcoNail(R) in the Treatment of Onychomycosis 5Prepared Remarks of Attorney General Michael B. Mukasey Before the House Judiciary Committee 2Prepared Remarks of Attorney General Michael B. Mukasey Before the House Judiciary Committee 3Taligen Therapeutics Initiates Corporate Growth Plan with Appointment of Abbie Celniker, Ph.D., as CEO and Establishment of Cambridge, Mass., Headquarters 2Taligen Therapeutics Initiates Corporate Growth Plan with Appointment of Abbie Celniker, Ph.D., as CEO and Establishment of Cambridge, Mass., Headquarters 3ESBATechs Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops 3464 1ESBATechs Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops 3464 2ESBATechs Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops 3464 3Protect Your Adolescents Against More Than Just A Cold This Winter 12551 1Protect Your Adolescents Against More Than Just A Cold This Winter 12551 2Public Health Experts Argue for Integrated Services to Avert 7 Million HIV Infections by 2010 12549 1Public Health Experts Argue for Integrated Services to Avert 7 Million HIV Infections by 2010 12549 2Family Friends and Support Groups Add Picture Messaging to Inspire and Motivate Anywhere Anytime 12547 1Family Friends and Support Groups Add Picture Messaging to Inspire and Motivate Anywhere Anytime 12547 2
For Detection of Bile Component in Reflux Disease
The Medtronic G|3 Urodynamic System is designed to make,your job easier, with the intuitive Sensic Navigation,Software and increased hardware functionality and options.
...technology, pathology specimen imaging is now adva... manipulation, analysis, interpretation and telepa... is analogous to the change that occurred in radio... imaging departments and imaging clinics through t...
...phoresis system is designed to optimize and comple...RYS 2 utilizes liquid flow electrophoresis for app...ugh continuous sample feed and the use of eight ve..., a throughput of 90 serum protein results per hou...
Medicine Products: