Navigation Links
Clinical benefit of multiple sclerosis drug discovered at Rush University Medical Center
Date:4/5/2010

dy temperature and learned of 4-aminopyridine, or dalfampridine, which blocks the potassium ion channels in nerve fibers.

"The chemical was commonly used in physiology laboratories where scientists were studying normal nerve conduction, but at the time it was used clinically only by physicians in Bulgaria, then a Communist-block country," Davis said. "They didn't know how it worked, but they used it to help patients recover from anesthesia-induced paralysis more quickly."

In 1983, in a small proof-of-concept study, Davis and Stefoski injected the drug in 11 patients whose motor function and eyesight were impaired because of multiple sclerosis.

"It was stunning," Stefoski said. "After a single intravenous dose, the patients could walk better and see better."

Rush was granted market exclusivity by the FDA under the Orphan Drug Act of 1983 and licensed worldwide rights for dalfampridine first to Ireland-based Elan Corporation and subsequently to Acorda Therapeutics, Inc., located in Hawthorne, New York. This month, Acorda began marketing dalfampridine in the U.S. under the brand name Ampyra.

In two Phase III clinical trials conducted by Acorda, the drug yielded a consistent improvement in walking speed. Walking speed increased by about 25 percent in 35 percent of patients in one trial and in 43 percent of patients in the other, as measured by a standard test called the Timed 25-Foot Walk. Study participants who took the drug also experienced greater leg strength than those who took a placebo.

Stefoski said that although the drug has been approved specifically for the treatment of impaired walking, it also relieves other symptoms of multiple sclerosis, since it restores signal conduction in all the affected nerve fibers.

Multiple sclerosis is a chronic, often disabling autoimmune disease. According to the National Multiple Sclerosis Society, more than 2.5 million people worldwide and 400,00
'/>"/>

Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program
2. FDA Issues Guidance to Help Streamline Medical Device Clinical Trials
3. Clinical course of subepithelial lesions
4. Pluromed Announces Completion of Enrollment in LeGoo™ Cardiac Bypass Clinical Trial
5. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
6. Medpedia Launches New Clinical Trial Platform
7. Most Antidepressants Miss Key Target of Clinical Depression
8. Banner Health Systems Adopts Quantros Regulatory Reporting Management (RRM) to Manage Clinical Quality and Performance Data and Support Improvements in Quality of Care
9. Health Systems, Hospitals and Universities Nationwide Chose Epocrates in 2009 for Trusted Point-of-Care Clinical Information
10. European Cancer Organization supports a revision of the EU Clinical Trials Directive
11. Roche and Catalyst Resources Team to Explore RIA Healthcare Collaboration Solutions for Enhanced Clinical Diagnosis and Education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... August 30, 2014 The KSF (Kung ... and K.Warrior Search on November 8th, 2014 at the ... these events have introduced many notorious and notable fighters ... IWF and the UFC. , Among these KSF ... leave its doors armed with the virtues of true ...
(Date:8/30/2014)... Saturday 30 August 2014: The first multidisciplinary ... with acute coronary syndromes (ACS) are published today ... paper was written jointly by the European Heart ... (ACCA) and the European Association of Percutaneous Cardiovascular ... Professor Bulent Gorenek (Turkey), chairperson of the task ...
(Date:8/30/2014)... Saturday 30 August 2014: The first recommendations on ... pulmonary embolism are published today in new ESC ... by Professor Stavros V. Konstantinides (Germany/Greece) and Professor ... on the diagnosis and management of acute pulmonary ... Journal (1) and on the ESC Website. , ...
(Date:8/29/2014)... Daily Gossip writes in its review that this is actually ... method promises to teach readers how to eliminate the need ... sources for the production of energy. , Some of ... power. , The Home Made Energy review indicates that ... this is an online guide that will teach its users ...
(Date:8/29/2014)... Diego (PRWEB) August 30, 2014 Cancer ... their loved ones and caretakers. Author Eddie M. Leung knows ... cholangiocarcinoma or bile duct cancer, a very rare ... Year That Changed My Life” (published by Xlibris), he shares ... more importantly, he imparts a survivor’s testimony that this disease ...
Breaking Medicine News(10 mins):Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 3Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 4Health News:First multidisciplinary recommendations on management of arrhythmias in ACS patients 2Health News:First recommendations on all new oral anticoagulants in pulmonary embolism published 2Health News:Home Made Energy Review Exposes Simple Method to Access Alternative Energy Sources 2Health News:Eddie M. Leung Shares His Testimony As a Survivor of Cancer 2Health News:Eddie M. Leung Shares His Testimony As a Survivor of Cancer 3
... ... City, Nevada will address the Phoenix Thunderbird Chapter of the National Contract Management Association (NCMA) ... Act and its use in fighting fraud against the Government. , ... Phoenix, AZ (PRWEB) February 23, 2010 -- Qui Tam ...
... , ... ... ... ...
... , ... ... , , , , ... ...
... ... ... ... ...
... Annual breast cancer screening with both mammography and magnetic resonance ... improve life expectancy in women with an increased risk of ... March issue of Radiology . The findings support current ... highest risk of breast cancer, using both breast MRI and ...
... ... ... , ... , , , , ...
Cached Medicine News:Health News:Qui Tam Attorney Tim Terry to Speak at Phoenix Thunderbird Chapter of the National Contract Management Association (NCMA) 2Health News:Pew Report: Georgia Off Track in Providing Children with Dental Health Care They Need 2Health News:Pew Report: Georgia Off Track in Providing Children with Dental Health Care They Need 3Health News:Pew Report: Georgia Off Track in Providing Children with Dental Health Care They Need 4Health News:Pew Report: Georgia Off Track in Providing Children with Dental Health Care They Need 5Health News:Pew Report: Georgia Off Track in Providing Children with Dental Health Care They Need 6Health News:Pew Report: Georgia Off Track in Providing Children with Dental Health Care They Need 7Health News:March of Dimes Provides $2.6 Million in New Funding for Preterm Birth Research 2Health News:March of Dimes Provides $2.6 Million in New Funding for Preterm Birth Research 3Health News:March of Dimes Provides $2.6 Million in New Funding for Preterm Birth Research 4Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 2Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 3Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 4Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 5Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 6Health News:Pew Report: Connecticut is a National Leader in Addressing Children's Dental Health 7Health News:Combined mammography and breast MRI useful for some high-risk women 2Health News:At Risk Children Receive Free Dental Services at Communities In Schools Clinic 2Health News:At Risk Children Receive Free Dental Services at Communities In Schools Clinic 3Health News:At Risk Children Receive Free Dental Services at Communities In Schools Clinic 4
(Date:8/29/2014)...  Abaxis, Inc. (NasdaqGS: ABAX ), a ... to the medical, research and veterinary markets, announced today ... Officer, will present at the CL King 12 th ... 9, 2014 at 12:30 p.m. ET. The conference will ... New York City . ...
(Date:8/29/2014)... , Industry professionals and ... Tweetchat taking place in real-time at CPhI Worldwide  ... UBM Live , announces the launch of ... of its kind global industry-wide Tweetchat for pharma ... aimed to stimulate conversations on key industry issues ...
(Date:8/28/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Needle-Free Delivery: Technology ... http://www.reportlinker.com/p02332847/Needle-Free-Delivery-Technology-and-Market-Forecast-2014-2024.html Report Details ... commercial prospects What does the future hold ... new report shows you the potential revenues ...
Breaking Medicine Technology:Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 2Needle-Free Delivery: Technology and Market Forecast 2014-2024 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 4Needle-Free Delivery: Technology and Market Forecast 2014-2024 5Needle-Free Delivery: Technology and Market Forecast 2014-2024 6Needle-Free Delivery: Technology and Market Forecast 2014-2024 7Needle-Free Delivery: Technology and Market Forecast 2014-2024 8Needle-Free Delivery: Technology and Market Forecast 2014-2024 9Needle-Free Delivery: Technology and Market Forecast 2014-2024 10Needle-Free Delivery: Technology and Market Forecast 2014-2024 11Needle-Free Delivery: Technology and Market Forecast 2014-2024 12Needle-Free Delivery: Technology and Market Forecast 2014-2024 13Needle-Free Delivery: Technology and Market Forecast 2014-2024 14Needle-Free Delivery: Technology and Market Forecast 2014-2024 15Needle-Free Delivery: Technology and Market Forecast 2014-2024 16Needle-Free Delivery: Technology and Market Forecast 2014-2024 17Needle-Free Delivery: Technology and Market Forecast 2014-2024 18
... 2012 ConvaTec, a world-leading developer and marketer of ... announces that Ken Berger will assume the position of ... Board of Directors. Berger joins ConvaTec from ... years, most recently as Senior Vice President and Group ...
...  Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN ) will ... , Citi 2012 Global Healthcare Conference at 3:00 p.m. ... RBC Capital Markets, Healthcare Conference at 9:00 a.m. Eastern ... sessions may be accessed through the Company,s web site, ...
Cached Medicine Technology:ConvaTec Announces the Appointment of Ken Berger to the Position of CEO Effective March 6, 2012 2Regeneron Announces February 2012 Investor Conference Presentations 2
... Radiation Protection Goggles fit ... be used by the ... leaded glass, 1.0 mm ... provide increased scatter radiation ...
QualCraft™ Euro Lite has a molded nylon frame that fits most faces. Universal keyhole nose bridge fits narrow to average noses. Available with or without lead vinyl-lined side shields....
QualCraft™ Radiation Protection Eyewear providex maximum comfort and eye protection! Lenses made of 0.75 mm leaded glass. Side shields of 0.30 mm leaded acrylic help seal out scatter radiation ...
Qualcraft™ Radiation Readers, Wraparound Glasses. Protect yourself and have close-vision clarity....
Medicine Products: