Navigation Links
Cleveland researchers find possible breakthrough to relieve pain following spinal cord injury
Date:11/30/2011

Cleveland -- A collaborative research group led by researchers at Cleveland Clinic published findings that indicate a one-time injection immediately after spinal cord injury can limit pain for an extended period of time.

Fibronectin a protein that exists naturally in humans supports the survival, growth and communication of neurons in the brain and spinal cord. The researchers discovered, through testing in an animal model, that an injection of fibronectin into the spinal cord activates specific signaling pathways and results in pain-curbing effects.

"We are very pleased with the results from the fibronectin injection," said Ching-Yi Lin, Ph.D., a researcher in the Department of Neurosciences in Cleveland Clinic's Lerner Research Institute. "Perhaps this will signal a change in pain management after spinal cord injury."

Previous research has shown that spinal cord injury increases the permeability of the blood-spinal cord barrier, causing chronic pain due to exposure of the spinal cord to inflammatory cells. Pain is a particularly important problem after spinal cord injury since the type of pain that ensues after a spinal cord injury is considered even more debilitating than the paralysis itself.

The findings were published in the December issue of the Journal of Neurotrauma and were presented at the annual meeting of Society of Neuroscience. This is a collaborative project between Lin and Yu-Shang Lee, Ph.D., both of the Department of Neurosciences in Cleveland Clinic's Lerner Research Institute; Vernon Lin, M.D., Ph.D., Department of Physical Medicine and Rehabilitation, Cleveland Clinic; and Jerry Silver, Ph.D., Department of Neurosciences, Case Western Reserve University.

While the exact mechanisms underlying the possible fibronectin connection to the relief of chronic pain are not clear yet, results show that fibronectin not only maintained the integrity of the blood-spinal cord barrier but also suppressed the inflammatory response significantly over an eight-month period. Researchers found that fibronectin reversed spinal cord injury-induced decreases in serotonin, a neurotransmitter that plays an important role in pain perception.

The next stage of the study is to test the delayed fibronectin treatment on the inhibition of chronic pain after spinal cord injury, which is more clinically relevant. There is an indication that this treatment also works at later time points.


'/>"/>
Contact: Dan Doron
dorond@ccf.org
216-312-0428
Cleveland Clinic
Source:Eurekalert

Related medicine news :

1. Cleveland Clinic nephrologist earns Federal grant for study of kidney disease management
2. Cleveland Clinic to establish chair for preventive cardiology from Cleveland Foundation
3. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
4. Community rallies to fight obesity in Clevelands urban youth
5. Carefx to Collaborate with the Cleveland Clinic to Commercialize CCF Business Intelligence Solution
6. Cleveland Attorneys Recognized as Ohio Super Lawyers on 2010 List
7. Cleveland Cavalier Darnell Jackson teams with Big Brothers Big Sisters of Greater Cleveland to Issue “Mentoring Challenge”
8. Cleveland Medical Malpractice Attorney Obtains Settlement in Wrongful Death Case
9. Sunquest Completes System-Wide Implementation at Cleveland Clinic Hospital Laboratories
10. Researchers examine role of inflammatory mechanisms in a healing heart
11. WSU researchers use a 3D printer to make bone-like material
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... A revolution is underway. Brooklyn-based company, ... for the millions of people who require these medical transport services annually. ... the use of technology. Now, SmartEMS has put forth an industry-changing app that ...
(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: