Navigation Links
Cleveland researchers find possible breakthrough to relieve pain following spinal cord injury
Date:11/30/2011

Cleveland -- A collaborative research group led by researchers at Cleveland Clinic published findings that indicate a one-time injection immediately after spinal cord injury can limit pain for an extended period of time.

Fibronectin a protein that exists naturally in humans supports the survival, growth and communication of neurons in the brain and spinal cord. The researchers discovered, through testing in an animal model, that an injection of fibronectin into the spinal cord activates specific signaling pathways and results in pain-curbing effects.

"We are very pleased with the results from the fibronectin injection," said Ching-Yi Lin, Ph.D., a researcher in the Department of Neurosciences in Cleveland Clinic's Lerner Research Institute. "Perhaps this will signal a change in pain management after spinal cord injury."

Previous research has shown that spinal cord injury increases the permeability of the blood-spinal cord barrier, causing chronic pain due to exposure of the spinal cord to inflammatory cells. Pain is a particularly important problem after spinal cord injury since the type of pain that ensues after a spinal cord injury is considered even more debilitating than the paralysis itself.

The findings were published in the December issue of the Journal of Neurotrauma and were presented at the annual meeting of Society of Neuroscience. This is a collaborative project between Lin and Yu-Shang Lee, Ph.D., both of the Department of Neurosciences in Cleveland Clinic's Lerner Research Institute; Vernon Lin, M.D., Ph.D., Department of Physical Medicine and Rehabilitation, Cleveland Clinic; and Jerry Silver, Ph.D., Department of Neurosciences, Case Western Reserve University.

While the exact mechanisms underlying the possible fibronectin connection to the relief of chronic pain are not clear yet, results show that fibronectin not only maintained the integrity of the blood-spinal cord barrier but also suppressed the inflammatory response significantly over an eight-month period. Researchers found that fibronectin reversed spinal cord injury-induced decreases in serotonin, a neurotransmitter that plays an important role in pain perception.

The next stage of the study is to test the delayed fibronectin treatment on the inhibition of chronic pain after spinal cord injury, which is more clinically relevant. There is an indication that this treatment also works at later time points.


'/>"/>
Contact: Dan Doron
dorond@ccf.org
216-312-0428
Cleveland Clinic
Source:Eurekalert

Related medicine news :

1. Cleveland Clinic nephrologist earns Federal grant for study of kidney disease management
2. Cleveland Clinic to establish chair for preventive cardiology from Cleveland Foundation
3. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
4. Community rallies to fight obesity in Clevelands urban youth
5. Carefx to Collaborate with the Cleveland Clinic to Commercialize CCF Business Intelligence Solution
6. Cleveland Attorneys Recognized as Ohio Super Lawyers on 2010 List
7. Cleveland Cavalier Darnell Jackson teams with Big Brothers Big Sisters of Greater Cleveland to Issue “Mentoring Challenge”
8. Cleveland Medical Malpractice Attorney Obtains Settlement in Wrongful Death Case
9. Sunquest Completes System-Wide Implementation at Cleveland Clinic Hospital Laboratories
10. Researchers examine role of inflammatory mechanisms in a healing heart
11. WSU researchers use a 3D printer to make bone-like material
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... 28, 2017 , ... Tuesday, March 28, 2017, is the annual American Diabetes ... Risk Test to find out if they are at risk for developing Type 2 ... the evening sky by programming the LAX pylons the color red. Downtown’s U.S. Bank ...
(Date:3/28/2017)... NEW YORK (PRWEB) , ... March 28, 2017 ... ... development, NTX Technology™, is the first technology to directly address the resolution to ... Organization. NTX Technology™ is a patented compound of FDA and TTB approved ingredients ...
(Date:3/28/2017)... ... March 28, 2017 , ... Resoundant, Inc., the developer ... the Siemens Healthineers annual customer education symposium, a world-class learning conference that offers ... March 27 - 31, 2017 at the Atlanta Marriott Marquis in Atlanta, Georgia. ...
(Date:3/28/2017)... ... March 29, 2017 , ... The ... Dr. Isabella Wentz, Pharm.D., FASCP. The program was recently launched on March 1, ... questions regarding thyroid function. , Dr. Izabella Wentz is a licensed pharmacist ...
(Date:3/28/2017)... WA (PRWEB) , ... March 28, 2017 , ... ... a 22% share of all holidays (IBT World Travel Trends Report). As travelers ... challenging, include a range in temperatures, and prolonged sun exposure. In response, the ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... , March 28, 2017  Medeon Biodesign, Inc., ... company, is pleased to announce that the Company ... of Panther Orthopedics, Inc., a San ... fixation solutions for orthopedic extremity applications.  ... expand rapidly, primarily due to procedure volume growth, ...
(Date:3/28/2017)... , March 28, 2017  Rosen Law Firm, ... of a class action lawsuit on behalf of purchasers ... KTOV ) pursuant and/or traceable to Kitov,s initial public ... and/or on the open market from November 20, 2015 ... Period"). The lawsuit seeks to recover damages for Kitov ...
(Date:3/28/2017)... Summary GBI ... a Key Component of Multichannel Marketing" provides a ... in the digital age. While the pharmaceutical ... advancements, it has been much slower to adopt ... traditional channels and methods. However, the decreasing effectiveness ...
Breaking Medicine Technology: