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Cleveland Clinic's preventive breast cancer vaccine development takes step forward
Date:9/17/2013

ing healthy cancer-free women with pre-emptive immunity against emerging breast tumors," said Tuohy. "We propose to provide women with an immune defense or shield that will protect them from developing breast cancer. Our data show that safe and effective immune protection against this disease can be induced by vaccinating against proteins that are no longer expressed in aging breast tissues but are significantly overexpressed in triple-negative breast cancer, the most aggressive and lethal form of this disease. We hope to provide women with a safe, effective and relatively benign alternative to invasive prophylactic mastectomy."

Triple-negative breast cancer has a higher recurrence rate than other forms of breast cancer and is insensitive to current forms of adjuvant therapy. It's the predominant form of breast cancer that occurs, for example, in women with BRCA1 mutations.

G. Thomas Budd, M.D., of Cleveland Clinic's Taussig Cancer Institute, will be on the company's scientific advisory board charged with the design and execution of the clinical trial protocol.

The first (Phase Ia) trial will involve women with triple-negative breast cancer who have recovered from current standard of care involving chemotherapy, radiation therapy, and/or surgery. This trial will determine the dose and frequency of vaccination needed to provide an optimum immune response. The second (Phase Ib) trial will involve healthy cancer-free women at high risk for developing breast cancer who have decided to undergo voluntary bilateral mastectomy to lower their risk. This trial will focus on the safety of the vaccine by examining the removed breast tissue for any potential changes.

"We expect these clinical trials to lead to more advanced trials designed to determine the effectiveness of the vaccine in treating triple-negative breast cancer, as well as its potential for immunoprevention," said Dr. Budd.


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Contact: Joe Milicia
milicij2@ccf.org
216-636-5873
Cleveland Clinic
Source:Eurekalert

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