Navigation Links
Cleveland Clinic's preventive breast cancer vaccine development takes step forward
Date:9/17/2013

Tuesday, Sept. 17, 2013, Cleveland: Cleveland Clinic Innovations has created a spin-off company to develop a preventive breast cancer vaccine based on research from Cleveland Clinic's Lerner Research Institute.

The new company, Shield Biotech, will complete preclinical development and seek permission from the FDA to test the vaccine as an investigational new drug in proof-of-concept, first-in-human clinical trials. The trials are expected to start within two years and will take about three years to complete.

"The mission of Shield Biotech will be to translate the scientific research on a breast cancer vaccine, led by Vincent Tuohy, Ph.D., at Cleveland Clinic, into a viable preventive alternative for the patients who may benefit," said Thomas Graham, MD, Cleveland Clinic's Chief Innovation Officer. "We believe that the vaccine has the potential to stop the more lethal forms of breast cancer, as well as inhibiting the recurrence of triple-negative breast cancer in women after they have recovered from their initial disease."

Initially, Shield Biotech will extend the development to the clinical stage in which the vaccine will be tested in two Phase I clinical trials as part of the process to obtain FDA approval. These trials are designed to establish the safety of the vaccine in women and to characterize and optimize the immune response.

Researchers at Cleveland Clinic's Lerner Research Institute found that a single vaccination could prevent breast tumors from occurring in mice genetically bred to develop breast cancer, while also inhibiting the growth of already existing breast tumors. The research was originally published in Nature Medicine in 2010.

Tuohy, the principal investigator on the original vaccine study, and an immunologist in Cleveland Clinic's Lerner Research Institute, will be Shield Biotech's chief science officer.

"We have proposed that breast cancer may be effectively controlled by provid
'/>"/>

Contact: Joe Milicia
milicij2@ccf.org
216-636-5873
Cleveland Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cleveland Clinic selected to participate in National MDS Clinical Research Consortium
2. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
3. Cleveland Clinic Florida receives approval for transplant programs at Weston Facilities
4. Cleveland Clinic researchers investigating potential drug for treatment of Alzheimers disease
5. Cleveland Clinic study shows vitamin E may decrease cancer risk in Cowden syndrome patients
6. University Hospitals & Philips Healthcare to showcase imaging technology at Cleveland Medical Mart
7. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
8. Redskins Quarterback & Lynx Shreds Athlete Kirk Cousins will Start Today vs. Cleveland Browns for Injured RG3
9. Cleveland Clinic researcher receives grant to fund autism research
10. Cleveland Clinic study shows bariatric surgery restores pancreatic function by targeting belly fat
11. Vein Expert in Winston-Salem, NC Participates in Elite Cleveland Clinic Seminar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 28, 2014 (HealthDay News) -- Endurance runners are far ... undetected heart condition, according to a new study. ... in events in warm climates are actually 10 times ... Yet, the less common sudden death of a young ... such as an irregular heartbeat, often gets a lot ...
(Date:7/28/2014)... not divide unless there is enough oxygen present to ... cell types circumvent this rule. Researchers at The Johns ... the cells, warning signals, enabling cancers to continue to ... process, the researchers found that lysosomes the cell,s ... They also uncovered new evidence that certain drugs can ...
(Date:7/28/2014)... 2014 Parker Waichman LLP, a personal injury ... that the heroes of 9/11 are never forgotten, comments that ... important deadline. According to a VCF message dated ... cancer on or before October 12, 2012 must file a ... and others who were allegedly injured by the toxic dust ...
(Date:7/28/2014)... NY (PRWEB) July 28, 2014 The ... organization that has donated more than 200,000 books to ... 2001, announces the launch of Brooke’s Cooks, a new ... while encouraging healthy living among at-risk children and their ... will include a series of nutrition information workshops, cooking ...
(Date:7/28/2014)... July 28, 2014 Bariatric Eating, a ... announced that it will be introducing three additional flavors ... this summer. The additional flavors include: , Inspire Summer ... protein , Inspire Pomegranate Razz Berry -­ Pomegranate, razz ... soft-serve vanilla cone , Bariatric Eating's Inspire protein ...
Breaking Medicine News(10 mins):Health News:Heat Stroke a Greater Threat to Endurance Runners Than Heart Problems: Study 2Health News:Cell's recycling center implicated in division decisions 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2
... a night,s rest may be the cause, research finds , ... the body,s production of the hormone melatonin, potentially leading to ... people often have problems with sleep after a brain injury, ... these problems," study author Shantha Rajaratnam of Monash University in ...
... is available by prescription under trade name Xenical and ... -- Responding to reports of rare but sometimes severe ... announced revised labels for a widely used weight-loss drug. ... the trade name Xenical and over-the-counter as Alli. , ...
... idea of individualized therapies, experts say , WEDNESDAY, May 26 ... not two, but potentially tens of thousands of genetic mutations ... A sample from a lung tumor from a heavy smoker ... 27 issue of Nature . , "People in the ...
... of individualized therapies, experts say , WEDNESDAY, May 26 (HealthDay ... two, but potentially tens of thousands of genetic mutations which, ... sample from a lung tumor from a heavy smoker revealed ... issue of Nature . , "People in the field ...
... development of a fast, simple, inexpensive method for determining ... skin allergies in people -- a method that does ... ACS, Chemical Research in Toxicology , a monthly ... the existence of public sentiment against the use of ...
... 26, 2010) Joan W. Miller, M.D., the HMS Henry ... of ophthalmology at Massachusetts Eye and Ear Infirmary and the ... Martin Dean,s Leadership Award for the Advancement of Women Faculty. ... was initiated by Joseph Martin, former HMS dean, in 1998. ...
Cached Medicine News:Health News:Brain Injuries May Lead to Sleep Woes 2Health News:Rare Cases of Liver Damage Tied to Weight-Loss Drug 2Health News:Rare Cases of Liver Damage Tied to Weight-Loss Drug 3Health News:Single Lung Tumor Contains 50,000 Mutations 2Health News:Single Lung Tumor Contains 50,000 Mutated Genes 2Health News:Joan Miller, M.D., receives 2010 Leadership Award for the Advancement of Women Faculty 2
(Date:7/28/2014)... , July 28, 2014 /PRNewswire-iReach/ -- June 28 th , ... which has developed the AMAS cancer test, is making its ... To date, the test, which is a serum-based in vitro ... emerging as a significant tool in the fight against cancer ... With an estimated 17 million cancer survivors in the ...
(Date:7/28/2014)... , July 28, 2014  Surgical Theater, LLC ... to its Business Advisory Board. New members include ... President for Business Development and New Technologies for ... , former Senior Vice President and General Manager ... Theater applies flight simulation technology to brain surgery ...
(Date:7/28/2014)... , July 28, 2014  VigeneTech, Inc, in ... of LEGENDplex™ Data Analysis Software, an OEM software ... cytometers.  BioLegend develops and offers varieties of bead-based ... With the support of VigeneTech,s data analysis software, ... analyzed and easily reported LEGENDplex™ ...
Breaking Medicine Technology:Oncolab, Inc. Exhibits Pioneering AMAS Cancer Test at AACC 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5VigeneTech Releases New Powerful Software for Flow Cytometry Data Analysis 2
... LAKE CITY, Jan. 28, 2011 TechniScan (OTC Bulletin ... engaged in the development and commercialization of an automated ... Robinson, Chief Executive Officer, will present at RetailInvestorConferences.com. DATE: ... ESTLINK: , www.retailinvestorconferences.com This will be a live, ...
... BioSciences, Inc. (NasdaqCM: DARA), a biopharmaceutical development company ... through proof of concept in humans for subsequent ... today that Richard Franco, CEO, will present at ... 5:00 PM ESTLINK: , www.retailinvestorconferences.com This will ...
Cached Medicine Technology:TechniScan to Present Live, Online at RetailInvestorConferences.com on February 3rd 2DARA BioSciences to Present Live at RetailInvestorConferences.com on February 3 2DARA BioSciences to Present Live at RetailInvestorConferences.com on February 3 3
... The NU-5510 DHD AutoFlow Direct ... HEPA filtration guarantying the greatest control ... cycles, both at 95C wet decontamination ... are exceptionally useful for cell line ...
... upright freezer uses ultra-thin vacuum insulation ... urethane insulation, to increase storage capacity, ... (336) 2" boxes or 3,336 samples. ... reduces energy consumption and extends compressor ...
... Advanced Series CO2 Incubators ... reliability. Microprocessor achieves precise temperature ... natural evaporation & RH% is ... CO2 and RH are displayed ...
... incubator with 6-sided direct heating provides ... lighter-weight incubator with greater internal storage ... HEPA filtered CO2 inlet, heated outer ... fanless, convection air circulation optimize culture ...
Medicine Products: