Navigation Links
Cleveland Clinic researchers investigating potential drug for treatment of Alzheimer's disease
Date:8/31/2012

Friday, Aug. 31, 2012, Cleveland: A compound developed to treat neuropathic pain has shown potential as an innovative treatment for Alzheimer's disease, according to a study by researchers at Cleveland Clinic's Lerner Research Institute and Anesthesiology Institute.

"Cleveland Clinic dedicated two years of research into the examination of this compound and our findings show it could represent a novel therapeutic target in the treatment of Alzheimer's disease," said Mohamed Naguib, M.D., Professor of Anesthesiology, Cleveland Clinic Lerner College of Medicine. "Development of this compound as a potential drug for Alzheimer's would take many more years, but this is a promising finding worthy of further investigation."

In a study published online in the Neurobiology of Aging, the compound MDA7 induced beneficial immune responses that limited the development of Alzheimer's disease. Treatment with the compound restored cognition, memory and synaptic plasticity a key neurological foundation of learning and memory in an animal model.

Neuroinflammation is an important mechanism involved in the progression of Alzheimer's disease. The MDA7 compound has anti-inflammatory properties that act on the CB2 receptor one of the two cannabinoid receptors in the body but without the negative side effects normally seen with cannabinoid compounds.

Alzheimer's disease is an irreversible, fatal brain disease that slowly destroys memory and thinking skills. About 5 million people in the United States have Alzheimer's disease. With the aging of the population, and without successful treatment, there will be 16 million Americans and 106 million people worldwide with Alzheimer's by 2050, according to the 2011 Alzheimer's Disease Facts and Figures report from the Alzheimer's Association.


'/>"/>

Contact: Joe Milicia
milicij2@ccf.org
216-636-5873
Cleveland Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Cleveland Clinic selected to participate in National MDS Clinical Research Consortium
2. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
3. Cleveland Clinic Florida receives approval for transplant programs at Weston Facilities
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. First targeted nanomedicine to enter human clinical studies
6. Clinical insight improves treatment with new lung cancer drug
7. Clinical news alert from the American Academy of Orthopaedic Surgeons
8. Mayo Clinic launches whole genome breast cancer study
9. Mayo Clinic offers newly approved treatment for acid reflux disease
10. NYU Langone experts present research, clinical advances at neurosurgeons meeting
11. Mayo Clinic breast cancer study finds new type of mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... (PRWEB) July 13, 2014 The ... Copper, Molybdenum, Iron), Form (Chelated & Non Chelated), ... Geography - Global Trends and Forecast to 2018” ... with an analysis and forecasting of the global ... identifies the driving and restraining factors for the ...
(Date:7/13/2014)... MarketsandMarkets recently conducted a study ... Scanning; 3D rendering; Layout and Animation; Image Reconstruction]: ... 2018)”, which analyzes and studies the major market ... Europe, Eastern Europe, Middle East and Africa, Asia-Pacific ... competitive landscape of the 3D imaging market, providing ...
(Date:7/13/2014)... 2014 Athletes with a certain genetic ... concussions, according to research presented today at the American ... Meeting. The research marks the first of its kind ... known physical events that occur after a head injury. ... allele in the (GT)n genotype were four times more ...
(Date:7/13/2014)... Recently, MyDressCity.com, one of the most popular suppliers of ... its new range of elegant Quinceanera dresses . ... discounted prices. Worldwide clients can enjoy this special offer ... online shop, there are plenty of beautiful dresses for ... materials. MyDressCity.com’s hot items are prom gowns, bridesmaid gowns, ...
(Date:7/13/2014)... decreased ability to identify odors might indicate the ... examinations of the eye could indicate the build-up ... the brain, according to the results of four ... International Conference 2014 (AAIC 2014) in Copenhagen. , ... to identify odors was significantly associated with loss ...
Breaking Medicine News(10 mins):Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2Health News:Cheap Elegant Quinceanera Dresses Unveiled by MyDressCity.com 2Health News:Smell and eye tests show potential to detect Alzheimer's early 2Health News:Smell and eye tests show potential to detect Alzheimer's early 3Health News:Smell and eye tests show potential to detect Alzheimer's early 4Health News:Smell and eye tests show potential to detect Alzheimer's early 5Health News:Smell and eye tests show potential to detect Alzheimer's early 6Health News:Smell and eye tests show potential to detect Alzheimer's early 7
... How your food is cooked may be as important to ... about a new class of toxins that might soon become// ... disorders as trans fats. ,This class of ... the body through the consumption of grilled, fried, or broiled ...
... model of infantile spasms, improving the likelihood of finding ... suffer from these catastrophic epilepsy seizures, according to research. ... epilepsy seizure seen in infancy and early childhood. The ... the body, arms, and legs. The seizures typically last ...
... experience great difficulties in prison, but people such as drug ... to a study in the latest Journal of Advanced Nursing. ... the Faculty of Health and Social Care at the University ... of 111 prisoners in 12 prisons across the UK. ...
... of Medicine has helped confirm the reliability of a ... genetic makeup. ,The Stanford group was one ... genetic test can identify patients who are at high ... That means high-risk patients could be directed toward a ...
... has been a surge of teen suicides. In this space, ... lives in despair. However, this one is// different, and explains ... ,A teenage girl, called Ebony (name changed to protect ... to attempts of ending her life several times. She responded ...
... of pneumonia at the Sipahijala wildlife sanctuary-cum-zoo in Tripura, officials ... suffered from a bout of pneumonia as the state was ... ,"Inadequate sheds and enclosures in the zoo had ... open sky while it was raining heavily. The deaths occurred ...
Cached Medicine News:Health News:Food Preparation may Play a Bigger Role in Chronic Disease 2Health News:Food Preparation may Play a Bigger Role in Chronic Disease 3Health News:Food Preparation may Play a Bigger Role in Chronic Disease 4Health News:Chronically Ill Prisoners Face Great Healthcare Problems 2Health News:Chronically Ill Prisoners Face Great Healthcare Problems 3Health News:New Test Helps Identify Hepatitis C Patients at High Risk of Developing Cirrhosis 2Health News:New Test Helps Identify Hepatitis C Patients at High Risk of Developing Cirrhosis 3Health News:Dispirited Teens Work Up Team Spirit to End Their Lives 2
(Date:7/11/2014)... , July 11, 2014 Patient ... marketing and, consequently, organizations are turning to an ... As part of this evolving approach ... to educate, communicate and engage patients throughout their ... to patient empowerment. By mapping the patient journey ...
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Needles Market 2014-2018" report to their offering. ... hypodermic needle is a hollow needle commonly used with ... or to extract fluids from it. A hypodermic needle ... inject substances that cannot be ingested. Hypodermic needles are ...
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... the addition of the "Immunoprotein Diagnostic Testing ... at the highest CAGR of 6% and is ... report to their offering. ... for immunoprotein diagnostic testing has been segmented according ...
Breaking Medicine Technology:New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
Inquire...
Quick Release Holder for the 8000 Series Sliding Microtome. A simple to use hlder for wax cassettes. Accepts standard size wax cassettes (26 x 31 x 5mm). Can be specified instead of standard vice ...
Tilt Adapter for the 8000 Sliding Microtome to allow for orientation of the specimen....
... new SureCut M3500 Radial Microtome has a look ... and a range of functions and capabilities that ... Based on years of experience and knowledge but ... the SureCut M3500 Microtome will be the answer ...
Medicine Products: